Association between folic acid deficiency and disease and prevention strategies: a critical view

Detalhes bibliográficos
Autor(a) principal: Kimi UEHARA, Sofia
Data de Publicação: 2023
Outros Autores: ROSA, Glorimar
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9427
Resumo: Folic acid deficiency is associated with non-communicable chronic diseases, pregnancy-associated complications and neurodegenerative diseases. The objective of this paper was to discuss the role of folic acid in disease prevention, the epidemiological aspects of its deficiency and food fortification and supplementation. Articles were searched in the following databases: MedLine, SciELO, PubMed, Highwire Press and Science Direct. Only original studies with humans published between 2004 and 2010 were included. Folic acid is important for DNA methylation and prevention of hyperhomocysteinemia. It also presents antioxidant activity. Folic acid deficiency has been described in adolescents, women of childbearing age, pregnant women and the elderly. It is difficult to meet the folic acid requirement with diet alone, so fortified foods and supplements are necessary.It is important to assess folic acid levels before and after the implementation of such strategies to enable the development of better and more effective public strategies. It is also important to provide nutrition education for the Brazilian population for them to increase their consumption of dietary sources of folic acid.
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spelling Association between folic acid deficiency and disease and prevention strategies: a critical viewAssociação da deficiência de ácido fólico com alterações patológicas e estratégias para sua prevenção: uma visão críticaFolic acidFood fortificationNon-transmissible chronic diseasesDietary supplementsÁcido fólicoAlimentos fortificadosDoenças crônicas não-transmissíveisSuplementação dietéticaFolic acid deficiency is associated with non-communicable chronic diseases, pregnancy-associated complications and neurodegenerative diseases. The objective of this paper was to discuss the role of folic acid in disease prevention, the epidemiological aspects of its deficiency and food fortification and supplementation. Articles were searched in the following databases: MedLine, SciELO, PubMed, Highwire Press and Science Direct. Only original studies with humans published between 2004 and 2010 were included. Folic acid is important for DNA methylation and prevention of hyperhomocysteinemia. It also presents antioxidant activity. Folic acid deficiency has been described in adolescents, women of childbearing age, pregnant women and the elderly. It is difficult to meet the folic acid requirement with diet alone, so fortified foods and supplements are necessary.It is important to assess folic acid levels before and after the implementation of such strategies to enable the development of better and more effective public strategies. It is also important to provide nutrition education for the Brazilian population for them to increase their consumption of dietary sources of folic acid.A deficiência de ácido fólico está associada às doenças crônicas não-transmissíveis, complicações na gestação e doenças neurodegenerativas. Objetivou-se discutir o papel do ácido fólico na prevenção de doenças, os aspectos epidemiológicos de sua deficiência, fortificação dos alimentos e suplementação medicamentosa. Realizou-se levantamento bibliográfico, consultando as bases de dados para a obtenção dos artigos completos: MedLine, SciELO, PubMed, Highwire Press e Science Direct. Foram selecionados estudos realizados com seres humanos publicados entre 2004 e 2010. O ácido fólico é importante para as reações de metilação do ácido desoxirribonucléico, prevenção da hiper-homocisteinemia e atua como antioxidante. A deficiência dessa vitamina é descrita em adolescentes, mulheres em idade fértil, gestantes e em idosos. Seu alcance pela dieta é difícil, sendo necessária a inclusão de alimentos fortificados ou suplementos. É importante avaliar o estado nutricional de ácido fólico dos indivíduos antes e após a adoção dessas estratégias, de modo a gerar subsídios para elaboração de medidas governamentais mais adequadas e eficazes. Destacamos ainda a necessidade da reeducação nutricional para a população brasileira a fim de aumentar o consumo de alimentos fontes de ácido fólico. Núcleo de Editoração – PUC-Campinas2023-08-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9427Brazilian Journal of Nutrition; Vol. 23 No. 5 (2010): Revista de NutriçãoRevista de Nutrição; Vol. 23 Núm. 5 (2010): Revista de NutriçãoRevista de Nutrição; v. 23 n. 5 (2010): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9427/6798Copyright (c) 2023 Sofia Kimi UEHARA, Glorimar ROSAhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Kimi UEHARA, Sofia ROSA, Glorimar2023-08-29T14:38:42Zoai:ojs.periodicos.puc-campinas.edu.br:article/9427Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-08-29T14:38:42Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Association between folic acid deficiency and disease and prevention strategies: a critical view
Associação da deficiência de ácido fólico com alterações patológicas e estratégias para sua prevenção: uma visão crítica
title Association between folic acid deficiency and disease and prevention strategies: a critical view
spellingShingle Association between folic acid deficiency and disease and prevention strategies: a critical view
Kimi UEHARA, Sofia
Folic acid
Food fortification
Non-transmissible chronic diseases
Dietary supplements
Ácido fólico
Alimentos fortificados
Doenças crônicas não-transmissíveis
Suplementação dietética
title_short Association between folic acid deficiency and disease and prevention strategies: a critical view
title_full Association between folic acid deficiency and disease and prevention strategies: a critical view
title_fullStr Association between folic acid deficiency and disease and prevention strategies: a critical view
title_full_unstemmed Association between folic acid deficiency and disease and prevention strategies: a critical view
title_sort Association between folic acid deficiency and disease and prevention strategies: a critical view
author Kimi UEHARA, Sofia
author_facet Kimi UEHARA, Sofia
ROSA, Glorimar
author_role author
author2 ROSA, Glorimar
author2_role author
dc.contributor.author.fl_str_mv Kimi UEHARA, Sofia
ROSA, Glorimar
dc.subject.por.fl_str_mv Folic acid
Food fortification
Non-transmissible chronic diseases
Dietary supplements
Ácido fólico
Alimentos fortificados
Doenças crônicas não-transmissíveis
Suplementação dietética
topic Folic acid
Food fortification
Non-transmissible chronic diseases
Dietary supplements
Ácido fólico
Alimentos fortificados
Doenças crônicas não-transmissíveis
Suplementação dietética
description Folic acid deficiency is associated with non-communicable chronic diseases, pregnancy-associated complications and neurodegenerative diseases. The objective of this paper was to discuss the role of folic acid in disease prevention, the epidemiological aspects of its deficiency and food fortification and supplementation. Articles were searched in the following databases: MedLine, SciELO, PubMed, Highwire Press and Science Direct. Only original studies with humans published between 2004 and 2010 were included. Folic acid is important for DNA methylation and prevention of hyperhomocysteinemia. It also presents antioxidant activity. Folic acid deficiency has been described in adolescents, women of childbearing age, pregnant women and the elderly. It is difficult to meet the folic acid requirement with diet alone, so fortified foods and supplements are necessary.It is important to assess folic acid levels before and after the implementation of such strategies to enable the development of better and more effective public strategies. It is also important to provide nutrition education for the Brazilian population for them to increase their consumption of dietary sources of folic acid.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9427
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9427
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9427/6798
dc.rights.driver.fl_str_mv Copyright (c) 2023 Sofia Kimi UEHARA, Glorimar ROSA
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Sofia Kimi UEHARA, Glorimar ROSA
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 23 No. 5 (2010): Revista de Nutrição
Revista de Nutrição; Vol. 23 Núm. 5 (2010): Revista de Nutrição
Revista de Nutrição; v. 23 n. 5 (2010): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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