Micronutrients supplementation during the senescence: implications for the immunological functions

Detalhes bibliográficos
Autor(a) principal: Carvalho Garbi NOVAES, Maria Rita
Data de Publicação: 2023
Outros Autores: Kyomi ITO, Marina, Fernandes ARRUDA, Sandra, RODRIGUES, Polyana, Queiroz LISBOA, Adriana
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9838
Resumo: The increase of the elderly population is a world-wide common phenomenon. According to some projections, in the year 2050, older people will constitute about 22% of the world population. Immune system deregulation in aging individuals is mainly a result of changes in cell mediated immunity, characterized by an increased number of immature T lymphocytes (CD2+CD3-), a decrease of T virgin lymphocytes (CD45RA), an increase of memory T lymphocytes (CD45RO), and by an increase in T helper 2 cells associated with a decrease in T helper 1 subset. Although changes in humoral immunity are less accentuated in the aging process, lower affinity for antigens and a narrower spectrum of the antibodies were observed in older people, as a dysfunction of immune response. Recent studies show that, in the aging, the supplementation of specific micronutrients is effective in restoring the normal immune response
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spelling Micronutrients supplementation during the senescence: implications for the immunological functionsSuplementação de micronutrientes na senescência: implicações nos mecanismos imunológicosagingnutritional statusmicronutrientsimmune systemenvelhecimentoestado nutricionalmicronutrientessistema imuneThe increase of the elderly population is a world-wide common phenomenon. According to some projections, in the year 2050, older people will constitute about 22% of the world population. Immune system deregulation in aging individuals is mainly a result of changes in cell mediated immunity, characterized by an increased number of immature T lymphocytes (CD2+CD3-), a decrease of T virgin lymphocytes (CD45RA), an increase of memory T lymphocytes (CD45RO), and by an increase in T helper 2 cells associated with a decrease in T helper 1 subset. Although changes in humoral immunity are less accentuated in the aging process, lower affinity for antigens and a narrower spectrum of the antibodies were observed in older people, as a dysfunction of immune response. Recent studies show that, in the aging, the supplementation of specific micronutrients is effective in restoring the normal immune responseA prevalência de indivíduos idosos em detrimento de indivíduos jovens compreende um quadro comum na população mundial. As estimativas indicam que, em 2050, cerca de 22% da população mundial serão constituídos por indivíduos idosos. As mudanças no sistema imune do indivíduo idoso ocorrem acentuadamente na imunidade mediada por células, caracterizada pelo aumento do número de linfócitos T imaturos (CD2+CD3-), decréscimo do número de linfócitos T virgens (CD45RA), aumento dos linfócitos de memória (CD45RO), e aumento das células helper T2, com decréscimo das helper T1. Embora as mudanças na resposta humoral sejam menores no envelhecimento, a menor especificidade e afinidade dos anticorpos nos indivíduos idosos constituem uma diferenciação da resposta imune. Estudos recentes demonstram que no envelhecimento a suplementação de micronutrientes específicos exerce efeitos benéficos sobre o sistema imune.Núcleo de Editoração – PUC-Campinas2023-09-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9838Brazilian Journal of Nutrition; Vol. 18 No. 3 (2005): Revista de NutriçãoRevista de Nutrição; Vol. 18 Núm. 3 (2005): Revista de NutriçãoRevista de Nutrição; v. 18 n. 3 (2005): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9838/7177Copyright (c) 2023 Maria Rita Carvalho Garbi NOVAES, Marina Kyomi ITO, Sandra Fernandes ARRUDA, Polyana RODRIGUES, Adriana Queiroz LISBOAhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCarvalho Garbi NOVAES, Maria Rita Kyomi ITO, Marina Fernandes ARRUDA, SandraRODRIGUES, Polyana Queiroz LISBOA, Adriana 2023-09-22T11:11:43Zoai:ojs.periodicos.puc-campinas.edu.br:article/9838Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-09-22T11:11:43Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Micronutrients supplementation during the senescence: implications for the immunological functions
Suplementação de micronutrientes na senescência: implicações nos mecanismos imunológicos
title Micronutrients supplementation during the senescence: implications for the immunological functions
spellingShingle Micronutrients supplementation during the senescence: implications for the immunological functions
Carvalho Garbi NOVAES, Maria Rita
aging
nutritional status
micronutrients
immune system
envelhecimento
estado nutricional
micronutrientes
sistema imune
title_short Micronutrients supplementation during the senescence: implications for the immunological functions
title_full Micronutrients supplementation during the senescence: implications for the immunological functions
title_fullStr Micronutrients supplementation during the senescence: implications for the immunological functions
title_full_unstemmed Micronutrients supplementation during the senescence: implications for the immunological functions
title_sort Micronutrients supplementation during the senescence: implications for the immunological functions
author Carvalho Garbi NOVAES, Maria Rita
author_facet Carvalho Garbi NOVAES, Maria Rita
Kyomi ITO, Marina
Fernandes ARRUDA, Sandra
RODRIGUES, Polyana
Queiroz LISBOA, Adriana
author_role author
author2 Kyomi ITO, Marina
Fernandes ARRUDA, Sandra
RODRIGUES, Polyana
Queiroz LISBOA, Adriana
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carvalho Garbi NOVAES, Maria Rita
Kyomi ITO, Marina
Fernandes ARRUDA, Sandra
RODRIGUES, Polyana
Queiroz LISBOA, Adriana
dc.subject.por.fl_str_mv aging
nutritional status
micronutrients
immune system
envelhecimento
estado nutricional
micronutrientes
sistema imune
topic aging
nutritional status
micronutrients
immune system
envelhecimento
estado nutricional
micronutrientes
sistema imune
description The increase of the elderly population is a world-wide common phenomenon. According to some projections, in the year 2050, older people will constitute about 22% of the world population. Immune system deregulation in aging individuals is mainly a result of changes in cell mediated immunity, characterized by an increased number of immature T lymphocytes (CD2+CD3-), a decrease of T virgin lymphocytes (CD45RA), an increase of memory T lymphocytes (CD45RO), and by an increase in T helper 2 cells associated with a decrease in T helper 1 subset. Although changes in humoral immunity are less accentuated in the aging process, lower affinity for antigens and a narrower spectrum of the antibodies were observed in older people, as a dysfunction of immune response. Recent studies show that, in the aging, the supplementation of specific micronutrients is effective in restoring the normal immune response
publishDate 2023
dc.date.none.fl_str_mv 2023-09-22
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9838
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9838
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9838/7177
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 18 No. 3 (2005): Revista de Nutrição
Revista de Nutrição; Vol. 18 Núm. 3 (2005): Revista de Nutrição
Revista de Nutrição; v. 18 n. 3 (2005): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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