Leptin and its influence in the pathophysiology of eating disorders

• Autor(a) principal: Miranda HERMSDORFF, Helen Hermana
• Data de Publicação: 2023
• Outros Autores: de Queiroga Milagres VIEIRA, Maria Aparecida, Bressan Resende MONTEIRO, Josefina
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista de Nutrição
• Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9772
• topic: anorexia nervosa; bulimia; eating; leptin; anorexia nervosa; bulimia; ingestão de alimentos; leptina

Leptin, a protein secreted by adipocytes, has a regulatory function in several organism systems such as theimmune, respiratory, and reproductive systems and in the energy balance via hypothalamic action. Its primaryaction occurs in the arcuate hypothalamic nucleus, where it begins a cascade of events that inhibits energyintake and enhances energy consumption. The concentration of leptin is influenced by adiposity and hormonaland nutritional factors. The scientific literature considers food restriction and binge episodes of anorexianervosa and bulimia, respectively, as determining factors of leptin circulation. Leptin levels are also alteredduring the treatment of these food disturbances, which indicates a relation between neuroendocrine alterations and eventual modifications in hunger and satiety signals and pathogenesis or clinical state of patients.Studies have reported on the short and long-term impact of these alterations on health. Therefore, this reviewaims to explain the function of leptin in the central and peripheral nervous systems, the mechanisms thatinterfere with its concentrations in food disturbances, and how this reflects on the health of anorectic andbulimic patients.