Omega-3 and omega-6 polyunsaturated fatty acids: metabolism in mammals and immune response

• Autor(a) principal: de Lima PERINI, João Ângelo
• Data de Publicação: 2023
• Outros Autores: Braidotti STEVANATO, Flávia, Cyléia SARGI, Sheisa, Laguila VISENTAINER, Jeane Eliete, Machado de Oliveira DALALIO, Márcia, MATSHUSHITA, Makoto, Evelázio de SOUZA, Nilson, Vergílio VISENTAINER, Jesuí
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista de Nutrição
• Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9448
• topic: Polyunsaturated fatty acids; Omega-3 fatty acids; Mice; Eicosanoids; Ácidos graxos poli-insaturados; Ácidos graxos ômega-3; Camundongos; Eicosanóides

Experiments with animals are very important for the improvement of science. The use of mice in experiments is due to their similarity with humans, the easy of raising and maintaining them and their very fast response. These animals have the same desaturase and elongase enzymes as humans and so they are used in research involving the incorporation and synthesis of fatty acids in tissues. The fatty acids omega-3 and omega-6 are extremely important in the human diet because they are not synthesized de novo and are precursors of very long-chain polyunsaturated fatty acids, such as the eicosapentaenoic, docosahexaenoic and arachidonic acids. These acids play important roles in animals, such as precursors of eicosanoids, which are directly involved inthe immune system and inflammatory response. The dietary n-3:n-6 intake ratio is important for assessing proper fatty acid intake and for preventing the development of diseases. Thus, this article assessed the incorporation of fatty acids in animal tissues and discussed the importance of n-3 fatty acids and its metabolites for the immune system.