Fatty acid profi le in erythrocytes associated with serum cytokines in pediatric cystic fi brosis patients
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Nutrição |
Texto Completo: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/7692 |
Resumo: | ObjectiveTo analyze erythrocyte fatty acid composition and its association with serum cytokine levels in pediatric cystic fi brosis patients. MethodsA cross-sectional study was performed at a reference center in Rio de Janeiro, Brazil. We have included all pediatric patients aged 5-19 years with confirmed cystic fibrosis diagnosis. Erythrocyte fatty acid composition and serum cytokine (TNF-α, IL-1β, IL-6 and IL-8) and C-reactive protein levels were measured. The cut-off point to determine essential fatty acids deficiency was the linoleic acid concentration of <21%. ResultsTwenty-six children (<10 years old) and thirty-one adolescents were studied. Most patients were female and heterozygous for DF508 mutation and suffered from exocrine pancreatic insufficiency. Both children and adolescents had lower linoleic acid concentration (<21%). TNF-α was the only pro-inflammatory marker whose levels were increased; the increase was greater in children. An association between fatty acid composition in erythrocytes and cytokines IL-1β and IL-6 was observed (p<0.05). ConclusionThe pediatric cystic fibrosis patients studied presented a deficiency of essential fatty acids, and an association between fatty acid profile in erythrocytes and serum pro-inflammatory cytokines was observed. These findings highlight the importance of this type of assessment that may open new possibilities for studying pathophysiology and treating cystic fibrosis patients, such as the dietary supplementation with n-3 fatty acids (eicosapentaenoic and docosahexaenoic acids). However, further longitudinal studies are needed for better clarification of the imbalance in lipid metabolism and inflammation in cystic fibrosis. |
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Fatty acid profi le in erythrocytes associated with serum cytokines in pediatric cystic fi brosis patientsObjectiveTo analyze erythrocyte fatty acid composition and its association with serum cytokine levels in pediatric cystic fi brosis patients. MethodsA cross-sectional study was performed at a reference center in Rio de Janeiro, Brazil. We have included all pediatric patients aged 5-19 years with confirmed cystic fibrosis diagnosis. Erythrocyte fatty acid composition and serum cytokine (TNF-α, IL-1β, IL-6 and IL-8) and C-reactive protein levels were measured. The cut-off point to determine essential fatty acids deficiency was the linoleic acid concentration of <21%. ResultsTwenty-six children (<10 years old) and thirty-one adolescents were studied. Most patients were female and heterozygous for DF508 mutation and suffered from exocrine pancreatic insufficiency. Both children and adolescents had lower linoleic acid concentration (<21%). TNF-α was the only pro-inflammatory marker whose levels were increased; the increase was greater in children. An association between fatty acid composition in erythrocytes and cytokines IL-1β and IL-6 was observed (p<0.05). ConclusionThe pediatric cystic fibrosis patients studied presented a deficiency of essential fatty acids, and an association between fatty acid profile in erythrocytes and serum pro-inflammatory cytokines was observed. These findings highlight the importance of this type of assessment that may open new possibilities for studying pathophysiology and treating cystic fibrosis patients, such as the dietary supplementation with n-3 fatty acids (eicosapentaenoic and docosahexaenoic acids). However, further longitudinal studies are needed for better clarification of the imbalance in lipid metabolism and inflammation in cystic fibrosis.Núcleo de Editoração – PUC-Campinas2023-03-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/7692Brazilian Journal of Nutrition; Vol. 31 No. 5 (2018): Revista de NutriçãoRevista de Nutrição; Vol. 31 Núm. 5 (2018): Revista de NutriçãoRevista de Nutrição; v. 31 n. 5 (2018): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/7692/5229Copyright (c) 2023 Ana Lucia Pereira da CUNHA, Ana Carolina Carioca da COSTA, Zilton VASCONCELOS, Maria das Graças TAVARES DO CARMO, Celia Regina Moutinho de Miranda CHAVEShttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPereira da CUNHA, Ana Lucia Carioca da COSTA, Ana Carolina VASCONCELOS, Zilton TAVARES DO CARMO, Maria das GraçasMoutinho de Miranda CHAVES, Celia Regina 2023-03-08T18:27:53Zoai:ojs.periodicos.puc-campinas.edu.br:article/7692Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-03-08T18:27:53Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
Fatty acid profi le in erythrocytes associated with serum cytokines in pediatric cystic fi brosis patients |
title |
Fatty acid profi le in erythrocytes associated with serum cytokines in pediatric cystic fi brosis patients |
spellingShingle |
Fatty acid profi le in erythrocytes associated with serum cytokines in pediatric cystic fi brosis patients Pereira da CUNHA, Ana Lucia |
title_short |
Fatty acid profi le in erythrocytes associated with serum cytokines in pediatric cystic fi brosis patients |
title_full |
Fatty acid profi le in erythrocytes associated with serum cytokines in pediatric cystic fi brosis patients |
title_fullStr |
Fatty acid profi le in erythrocytes associated with serum cytokines in pediatric cystic fi brosis patients |
title_full_unstemmed |
Fatty acid profi le in erythrocytes associated with serum cytokines in pediatric cystic fi brosis patients |
title_sort |
Fatty acid profi le in erythrocytes associated with serum cytokines in pediatric cystic fi brosis patients |
author |
Pereira da CUNHA, Ana Lucia |
author_facet |
Pereira da CUNHA, Ana Lucia Carioca da COSTA, Ana Carolina VASCONCELOS, Zilton TAVARES DO CARMO, Maria das Graças Moutinho de Miranda CHAVES, Celia Regina |
author_role |
author |
author2 |
Carioca da COSTA, Ana Carolina VASCONCELOS, Zilton TAVARES DO CARMO, Maria das Graças Moutinho de Miranda CHAVES, Celia Regina |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Pereira da CUNHA, Ana Lucia Carioca da COSTA, Ana Carolina VASCONCELOS, Zilton TAVARES DO CARMO, Maria das Graças Moutinho de Miranda CHAVES, Celia Regina |
description |
ObjectiveTo analyze erythrocyte fatty acid composition and its association with serum cytokine levels in pediatric cystic fi brosis patients. MethodsA cross-sectional study was performed at a reference center in Rio de Janeiro, Brazil. We have included all pediatric patients aged 5-19 years with confirmed cystic fibrosis diagnosis. Erythrocyte fatty acid composition and serum cytokine (TNF-α, IL-1β, IL-6 and IL-8) and C-reactive protein levels were measured. The cut-off point to determine essential fatty acids deficiency was the linoleic acid concentration of <21%. ResultsTwenty-six children (<10 years old) and thirty-one adolescents were studied. Most patients were female and heterozygous for DF508 mutation and suffered from exocrine pancreatic insufficiency. Both children and adolescents had lower linoleic acid concentration (<21%). TNF-α was the only pro-inflammatory marker whose levels were increased; the increase was greater in children. An association between fatty acid composition in erythrocytes and cytokines IL-1β and IL-6 was observed (p<0.05). ConclusionThe pediatric cystic fibrosis patients studied presented a deficiency of essential fatty acids, and an association between fatty acid profile in erythrocytes and serum pro-inflammatory cytokines was observed. These findings highlight the importance of this type of assessment that may open new possibilities for studying pathophysiology and treating cystic fibrosis patients, such as the dietary supplementation with n-3 fatty acids (eicosapentaenoic and docosahexaenoic acids). However, further longitudinal studies are needed for better clarification of the imbalance in lipid metabolism and inflammation in cystic fibrosis. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/7692 |
url |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/7692 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/7692/5229 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Nutrition; Vol. 31 No. 5 (2018): Revista de Nutrição Revista de Nutrição; Vol. 31 Núm. 5 (2018): Revista de Nutrição Revista de Nutrição; v. 31 n. 5 (2018): Revista de Nutrição 1678-9865 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Revista de Nutrição |
collection |
Revista de Nutrição |
repository.name.fl_str_mv |
Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
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1799126067889307648 |