VITAMIN SUPPLEMENTATION IN CANCER CHEMOPREVENTION

Detalhes bibliográficos
Autor(a) principal: de Melo SILVA, Cyntia Rosa
Data de Publicação: 2001
Outros Autores: Veloso NAVES, Maria Margareth
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/8976
Resumo: This work is a review of epidemiologic data about the relationship between vitamin intake and cancer prevention. Observational studies have strongly suggested an inverse association between fruit and vegetable intake and cancer risk, and a protector effect of C and E vitamins and carotenoids against some kinds of cancer. In intervention trials β-carotene was found to be deleterious to smokers, when supplemented in pharmacological doses isolated or associated with vitamin E or vitamin A. On the other hand, the consumption of antioxidants in physiological amounts may be effective against cancer, and this synergic action was observed in both in vivo model of carcinogenesis and epidemiologic intervention trial. It has been commended a generous daily consumption of fruits and vegetables, with amounts of C and E vitamins and carotenoids nearly to 150, 30, and 4 mg, respectively, and the vitaminsupplements are not recommended as chemopreventive agents against cancer.
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spelling VITAMIN SUPPLEMENTATION IN CANCER CHEMOPREVENTIONSUPLEMENTAÇÃO DE VITAMINAS NA PREVENÇÃO DE CÂNCERnutritional epidemiologychemopreventionvitaminsneoplasmsantioxidantsepidemiologia nutricionalquimioprevençãovitaminasneoplasiasantioxidantesThis work is a review of epidemiologic data about the relationship between vitamin intake and cancer prevention. Observational studies have strongly suggested an inverse association between fruit and vegetable intake and cancer risk, and a protector effect of C and E vitamins and carotenoids against some kinds of cancer. In intervention trials β-carotene was found to be deleterious to smokers, when supplemented in pharmacological doses isolated or associated with vitamin E or vitamin A. On the other hand, the consumption of antioxidants in physiological amounts may be effective against cancer, and this synergic action was observed in both in vivo model of carcinogenesis and epidemiologic intervention trial. It has been commended a generous daily consumption of fruits and vegetables, with amounts of C and E vitamins and carotenoids nearly to 150, 30, and 4 mg, respectively, and the vitaminsupplements are not recommended as chemopreventive agents against cancer.Este trabalho constitui uma revisão de dados epidemiológicos sobre a relação entre o consumo de vitaminas e prevenção de câncer. Estudos observacionais evidenciam uma associação inversa consistente entre a ingestão de frutas e hortaliças e risco de câncer, e um efeito protetor das vitaminas C, E e dos carotenóides contra certos tipos de câncer. Resultados de estudos de intervenção, na prevenção primária de câncer, são contraditórios, sendo que em dois desses estudos o β-caroteno, suplementado em doses consideradas farmacológicas, isolado ou associado à vitamina E ou à vitamina A, mostrou-se deletério para tabagistas. Ao contrário, a ingestão de doses mais fisiológicas de antioxidantes parece ser mais eficaz, sendo que a ação sinérgica dessas substâncias na quimioprevenção de câncer já foi demonstrada tanto em modelo in vivo de carcinogênese quanto em estudo epidemiológico de intervenção. Como estratégia de prevenção de câncer preconiza-se o consumo de dietas ricas em frutas e hortaliças, que aportem cerca de 150 mg de vitamina C, 30 mg de vitamina E e 4 mg de carotenóides. A ingestão de quantidades mais elevadas, na forma de suplementos, não está recomendada.Núcleo de Editoração – PUC-Campinas2001-08-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/8976Brazilian Journal of Nutrition; Vol. 14 No. 2 (2001): Revista de NutriçãoRevista de Nutrição; Vol. 14 Núm. 2 (2001): Revista de NutriçãoRevista de Nutrição; v. 14 n. 2 (2001): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/8976/6372Copyright (c) 2023 Cyntia Rosa de Melo SILVA, Maria Margareth Veloso NAVEShttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessde Melo SILVA, Cyntia Rosa Veloso NAVES, Maria Margareth2024-04-08T13:21:16Zoai:ojs.periodicos.puc-campinas.edu.br:article/8976Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2024-04-08T13:21:16Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv VITAMIN SUPPLEMENTATION IN CANCER CHEMOPREVENTION
SUPLEMENTAÇÃO DE VITAMINAS NA PREVENÇÃO DE CÂNCER
title VITAMIN SUPPLEMENTATION IN CANCER CHEMOPREVENTION
spellingShingle VITAMIN SUPPLEMENTATION IN CANCER CHEMOPREVENTION
de Melo SILVA, Cyntia Rosa
nutritional epidemiology
chemoprevention
vitamins
neoplasms
antioxidants
epidemiologia nutricional
quimioprevenção
vitaminas
neoplasias
antioxidantes
title_short VITAMIN SUPPLEMENTATION IN CANCER CHEMOPREVENTION
title_full VITAMIN SUPPLEMENTATION IN CANCER CHEMOPREVENTION
title_fullStr VITAMIN SUPPLEMENTATION IN CANCER CHEMOPREVENTION
title_full_unstemmed VITAMIN SUPPLEMENTATION IN CANCER CHEMOPREVENTION
title_sort VITAMIN SUPPLEMENTATION IN CANCER CHEMOPREVENTION
author de Melo SILVA, Cyntia Rosa
author_facet de Melo SILVA, Cyntia Rosa
Veloso NAVES, Maria Margareth
author_role author
author2 Veloso NAVES, Maria Margareth
author2_role author
dc.contributor.author.fl_str_mv de Melo SILVA, Cyntia Rosa
Veloso NAVES, Maria Margareth
dc.subject.por.fl_str_mv nutritional epidemiology
chemoprevention
vitamins
neoplasms
antioxidants
epidemiologia nutricional
quimioprevenção
vitaminas
neoplasias
antioxidantes
topic nutritional epidemiology
chemoprevention
vitamins
neoplasms
antioxidants
epidemiologia nutricional
quimioprevenção
vitaminas
neoplasias
antioxidantes
description This work is a review of epidemiologic data about the relationship between vitamin intake and cancer prevention. Observational studies have strongly suggested an inverse association between fruit and vegetable intake and cancer risk, and a protector effect of C and E vitamins and carotenoids against some kinds of cancer. In intervention trials β-carotene was found to be deleterious to smokers, when supplemented in pharmacological doses isolated or associated with vitamin E or vitamin A. On the other hand, the consumption of antioxidants in physiological amounts may be effective against cancer, and this synergic action was observed in both in vivo model of carcinogenesis and epidemiologic intervention trial. It has been commended a generous daily consumption of fruits and vegetables, with amounts of C and E vitamins and carotenoids nearly to 150, 30, and 4 mg, respectively, and the vitaminsupplements are not recommended as chemopreventive agents against cancer.
publishDate 2001
dc.date.none.fl_str_mv 2001-08-25
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/8976
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/8976
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/8976/6372
dc.rights.driver.fl_str_mv Copyright (c) 2023 Cyntia Rosa de Melo SILVA, Maria Margareth Veloso NAVES
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Cyntia Rosa de Melo SILVA, Maria Margareth Veloso NAVES
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 14 No. 2 (2001): Revista de Nutrição
Revista de Nutrição; Vol. 14 Núm. 2 (2001): Revista de Nutrição
Revista de Nutrição; v. 14 n. 2 (2001): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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