C-reactive protein and cardiometabolic risk factors in overweight or obese children and adolescents

• Autor(a) principal: da Silva CARDOSO, Anajás
• Data de Publicação: 2023
• Outros Autores: Oliveira CARDOSO, Renata, Franklin de CARVALHO, Danielle, COLLET, Neusa, Campos Muniz MEDEIROS, Carla
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista de Nutrição
• Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/8311
• topic: C-reactive protein; Cardiovascular diseases; Obesity; Risk factors; Proteína C-reativa; Doenças cardiovasculares; Obesidade; Fatores de risco

ObjectiveTo investigate the relationship between ultrasensitive C-reactive protein and cardiometabolic risk factors in overweight or obese childrenand adolescents. MethodsCross-sectional study conducted at the Center for Childhood Obesity in the period from April 2009 to April 2010, involving 185 overweight children and adolescents aged 2 to 18 years. Measures of ultrasensitive Creactive protein according to age, nutritional status, gender, race, cardiometabolic risk factors (waist circumference, lipid profile, impaired fasting glucose, high blood pressure and presence of insulin resistance) were compared through the Chi-square test and analysis of variance. All analyses were performed using the Statistical Package for the Social Sciences software version 17.0, adopting a significance level of 5%. ResultsAltered high-density lipoprotein was the most frequent cardiometabolic risk factor, and there was a significant association between altered ultrasensitive C-reactive protein values and severe obesity (p=0.005), high waist circumference (p<0.001), hypertriglyceridemia (p=0.037) and insulin resistance (p=0.002), as well as significantly higher body mass index (p=0.000), waist circumference (p=0.001), insulin (p=0.005) and index of glucose homeostasis values(p=0.005). ConclusionHigh prevalence of altered ultrasensitive C-reactive protein and significant association with severe obesity, waist circumference, hypertriglyceridemia and insulin resistance were observed.