Alanine aminotransferase and high sensitivity C-Reactive protein: correlates of cardiovascular risk factors in youth
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2008 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/14300 |
Resumo: | Texto completo: acesso restrito. p. 337-342 |
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Oliveira, Antônio Carlos Paula deAlmeida, Marcele S.Oliveira, Ana M.Silva, Agnaluce M.Adan, Luís Fernando FernandesLadeia, Ana Marice TeixeiraOliveira, Antônio Carlos Paula deAlmeida, Marcele S.Oliveira, Ana M.Silva, Agnaluce M.Adan, Luís Fernando FernandesLadeia, Ana Marice Teixeira2014-01-08T13:57:18Z20080022-3476http://repositorio.ufba.br/ri/handle/ri/14300v. 152, n. 3Texto completo: acesso restrito. p. 337-342Objective: The association between high-sensitivity C-reactive protein (hs-CRP) and alanine aminotransferase (ALT) with clinical/metabolic variables was evaluated in overweight Brazilian children and adolescents. Study design: Oral glucose tolerance test was performed in 407 students (273 overweight/obese, 11.3 ± 3.1 y). Measurements included body mass index (BMI), waist circumference (WC), blood pressure, lipids, insulin, hs-CRP, and ALT. Overweight/obese was defined using BMI z-score; insulin resistance (IR) by homeostatic model assessment: insulin resistance (HOMA-IR); and metabolic syndrome (MS) in accordance with the modified NCEP-ATPIII. Results: As weight increased, systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), insulin, HOMA-IR, hs-CRP, ALT, ALT, hs-CRP, and AST and the number of MS components (nMSc) also increased (P ≤ .001 for all). Subjects with hs-CRP and ALT above the median had higher BMI z-score, WC, SBP, DBP, TG, AST, insulin, HOMA-IR, and nMSc than those with both markers below the median (P ≤ .002 for all). After adjustment for age, sex and ethnicity, BMI z-score (OR, 1.5; CI, 1.38 to 1.86; P < .001), WC (OR,1.3; CI, 1.19 to 1.43; P < .001) SBP (OR, 1.2; CI, 1.03 to 1.38; P = .015), DBP (OR, 1.4; CI, 1.15 to 1.69; P < .001), TG (OR, 1.8; CI, 1.29 to 2.62; P < .001), insulin (OR, 1.4; CI, 1.23 to 1.71; P < .001), HOMA-IR (OR, 1.2; CI, 1.09 to 1.29; P < .001) and nMSc (OR, 2; CI, 1.16 to 3.47; P = .012) were independently associated with high ALT and hs-CRP. For every 5-cm increase in WC and every 1-point increase in BMI z-score, there were a 1.3- and 1.5-fold greater chance of having increased ALT and hs-CRP, respectively. Conclusions: Simultaneous measurements of ALT and hs-CRP should be considered as a screening test for metabolic syndrome and cardiovascular disease risk factors in overweight/obese children/adolescents.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-12-16T13:26:33Z No. of bitstreams: 1 1-s2.0-S0022347607006658-main.pdf: 135429 bytes, checksum: a96925983045339e5c66f2e646dd34db (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-08T13:57:18Z (GMT) No. of bitstreams: 1 1-s2.0-S0022347607006658-main.pdf: 135429 bytes, checksum: a96925983045339e5c66f2e646dd34db (MD5)Made available in DSpace on 2014-01-08T13:57:18Z (GMT). No. of bitstreams: 1 1-s2.0-S0022347607006658-main.pdf: 135429 bytes, checksum: a96925983045339e5c66f2e646dd34db (MD5) Previous issue date: 2008http://dx.doi.org/10.1016/j.jpeds.2007.07.013reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAC-Reactive ProteinAlanine TransaminaseCardiovascular SystemRisk FactorsAlanine aminotransferase and high sensitivity C-Reactive protein: correlates of cardiovascular risk factors in youthJournal of Pediatricsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL1-s2.0-S0022347607006658-main.pdf1-s2.0-S0022347607006658-main.pdfapplication/pdf135429https://repositorio.ufba.br/bitstream/ri/14300/1/1-s2.0-S0022347607006658-main.pdfa96925983045339e5c66f2e646dd34dbMD51LICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/14300/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52TEXT1-s2.0-S0022347607006658-main.pdf.txt1-s2.0-S0022347607006658-main.pdf.txtExtracted texttext/plain29944https://repositorio.ufba.br/bitstream/ri/14300/3/1-s2.0-S0022347607006658-main.pdf.txte1d49285434b8fdfc25a3797c32188d3MD53ri/143002022-07-05 14:03:30.891oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:03:30Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Alanine aminotransferase and high sensitivity C-Reactive protein: correlates of cardiovascular risk factors in youth |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Pediatrics |
| title |
Alanine aminotransferase and high sensitivity C-Reactive protein: correlates of cardiovascular risk factors in youth |
| spellingShingle |
Alanine aminotransferase and high sensitivity C-Reactive protein: correlates of cardiovascular risk factors in youth Oliveira, Antônio Carlos Paula de C-Reactive Protein Alanine Transaminase Cardiovascular System Risk Factors |
| title_short |
Alanine aminotransferase and high sensitivity C-Reactive protein: correlates of cardiovascular risk factors in youth |
| title_full |
Alanine aminotransferase and high sensitivity C-Reactive protein: correlates of cardiovascular risk factors in youth |
| title_fullStr |
Alanine aminotransferase and high sensitivity C-Reactive protein: correlates of cardiovascular risk factors in youth |
| title_full_unstemmed |
Alanine aminotransferase and high sensitivity C-Reactive protein: correlates of cardiovascular risk factors in youth |
| title_sort |
Alanine aminotransferase and high sensitivity C-Reactive protein: correlates of cardiovascular risk factors in youth |
| author |
Oliveira, Antônio Carlos Paula de |
| author_facet |
Oliveira, Antônio Carlos Paula de Almeida, Marcele S. Oliveira, Ana M. Silva, Agnaluce M. Adan, Luís Fernando Fernandes Ladeia, Ana Marice Teixeira |
| author_role |
author |
| author2 |
Almeida, Marcele S. Oliveira, Ana M. Silva, Agnaluce M. Adan, Luís Fernando Fernandes Ladeia, Ana Marice Teixeira |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Antônio Carlos Paula de Almeida, Marcele S. Oliveira, Ana M. Silva, Agnaluce M. Adan, Luís Fernando Fernandes Ladeia, Ana Marice Teixeira Oliveira, Antônio Carlos Paula de Almeida, Marcele S. Oliveira, Ana M. Silva, Agnaluce M. Adan, Luís Fernando Fernandes Ladeia, Ana Marice Teixeira |
| dc.subject.por.fl_str_mv |
C-Reactive Protein Alanine Transaminase Cardiovascular System Risk Factors |
| topic |
C-Reactive Protein Alanine Transaminase Cardiovascular System Risk Factors |
| description |
Texto completo: acesso restrito. p. 337-342 |
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2008 |
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2008 |
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2014-01-08T13:57:18Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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0022-3476 |
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v. 152, n. 3 |
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0022-3476 v. 152, n. 3 |
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http://dx.doi.org/10.1016/j.jpeds.2007.07.013 |
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reponame:Repositório Institucional da UFBA instname:Universidade Federal da Bahia (UFBA) instacron:UFBA |
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