Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile

Detalhes bibliográficos
Autor(a) principal: Branco SHINAGAWA, Fernanda
Data de Publicação: 2023
Outros Autores: Carvalho de SANTANA, Fernanda, MANCINI-FILHO, Jorge
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/8193
Resumo: ObjectiveThe aim of this study was to evaluate the effect of long term consumption of cold-pressed grape seed oil purchased in Brazil on the biochemical and inflammatory biomarkers of healthy rats. MethodsWeaned and healthy Wistar rats received two concentrations (3 and 6 mL/kg body weight) of grape seed and soy oil for 65 days. The parameters studied were food intake and body, liver, brain, and retroperitoneal adipose tissue weight. The fatty acid composition of the adipose tissue was also determined. Serum biochemical parameters, lipid peroxidation, and inflammatory profile were assessed, quantifying the cytokines tumor necrosis factor alpha, interleukin 10 and IL-6. ResultsGrape seed oil, regardless of dosage, promoted much fat accumulation on hepatic tissue and also increased serum lipid peroxidation. The highest dosage promoted the greatest incorporation of polyunsaturated fatty acids in the retroperitoneal adipose tissue. The biochemical parameters and serum inflammatory markers did not change. ConclusionGrape seed oil did not promote significant metabolic changes at either concentration but increased serum lipid peroxidation. 
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spelling Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profileEfeito do óleo de semente de uva prensado a frio nos marcadores bioquímicos e perfil inflamatório de ratosObjectiveThe aim of this study was to evaluate the effect of long term consumption of cold-pressed grape seed oil purchased in Brazil on the biochemical and inflammatory biomarkers of healthy rats. MethodsWeaned and healthy Wistar rats received two concentrations (3 and 6 mL/kg body weight) of grape seed and soy oil for 65 days. The parameters studied were food intake and body, liver, brain, and retroperitoneal adipose tissue weight. The fatty acid composition of the adipose tissue was also determined. Serum biochemical parameters, lipid peroxidation, and inflammatory profile were assessed, quantifying the cytokines tumor necrosis factor alpha, interleukin 10 and IL-6. ResultsGrape seed oil, regardless of dosage, promoted much fat accumulation on hepatic tissue and also increased serum lipid peroxidation. The highest dosage promoted the greatest incorporation of polyunsaturated fatty acids in the retroperitoneal adipose tissue. The biochemical parameters and serum inflammatory markers did not change. ConclusionGrape seed oil did not promote significant metabolic changes at either concentration but increased serum lipid peroxidation. ObjetivoO objetivo deste trabalho foi avaliar o efeito do consumo crônico do óleo de semente de uva, obtido do mercado brasileiro, nos marcadores bioquímicos e inflamatórios de ratos saudáveis. MétodosRatos Wistar, recém-desmamados e saudáveis, receberam por 65 dias óleo de semente de uva e soja em duas concentrações (3 e 6 mL/kg de peso corporal). Os parâmetros avaliados foram a ingestão alimentar, peso corporal e dos tecidos hepático, cerebral e adiposo retroperitonial; neste último, foi ainda realizado o perfil de ácidos graxos. A análise dos parâmetros bioquímicos, peroxidação lipídica e perfil inflamatório através da quantificação das citocinas TNF-α, IL-10 e IL-6 foi realizada no soro. ResultadosO óleo de semente de uva, independentemente da dose administrada, promoveu maior acúmulo de gordura no tecido hepático e aumento nos níveis de peroxidação lipídica do soro. Verificou-se que, quando consumido na maior dose, houve maior incorporação do ácido graxo linoleico no tecido adiposo retroperitonial. Modificações nos parâmetros bioquímicos e inflamatórios séricos não foram observadas. ConclusãoO consumo de óleo de semente de uva não provocou alterações metabólicas significantes em nenhuma das doses administradas ainda que se tenha observado uma elevação nos níveis de peroxidação lipídica sérica. Núcleo de Editoração – PUC-Campinas2023-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/8193Brazilian Journal of Nutrition; Vol. 28 No. 1 (2015): Revista de NutriçãoRevista de Nutrição; Vol. 28 Núm. 1 (2015): Revista de NutriçãoRevista de Nutrição; v. 28 n. 1 (2015): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/8193/5715Copyright (c) 2023 Fernanda Branco SHINAGAWA, Fernanda Carvalho de SANTANA, Jorge MANCINI-FILHOhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBranco SHINAGAWA, Fernanda Carvalho de SANTANA, Fernanda MANCINI-FILHO, Jorge2023-03-31T12:28:33Zoai:ojs.periodicos.puc-campinas.edu.br:article/8193Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-03-31T12:28:33Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile
Efeito do óleo de semente de uva prensado a frio nos marcadores bioquímicos e perfil inflamatório de ratos
title Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile
spellingShingle Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile
Branco SHINAGAWA, Fernanda
title_short Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile
title_full Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile
title_fullStr Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile
title_full_unstemmed Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile
title_sort Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile
author Branco SHINAGAWA, Fernanda
author_facet Branco SHINAGAWA, Fernanda
Carvalho de SANTANA, Fernanda
MANCINI-FILHO, Jorge
author_role author
author2 Carvalho de SANTANA, Fernanda
MANCINI-FILHO, Jorge
author2_role author
author
dc.contributor.author.fl_str_mv Branco SHINAGAWA, Fernanda
Carvalho de SANTANA, Fernanda
MANCINI-FILHO, Jorge
description ObjectiveThe aim of this study was to evaluate the effect of long term consumption of cold-pressed grape seed oil purchased in Brazil on the biochemical and inflammatory biomarkers of healthy rats. MethodsWeaned and healthy Wistar rats received two concentrations (3 and 6 mL/kg body weight) of grape seed and soy oil for 65 days. The parameters studied were food intake and body, liver, brain, and retroperitoneal adipose tissue weight. The fatty acid composition of the adipose tissue was also determined. Serum biochemical parameters, lipid peroxidation, and inflammatory profile were assessed, quantifying the cytokines tumor necrosis factor alpha, interleukin 10 and IL-6. ResultsGrape seed oil, regardless of dosage, promoted much fat accumulation on hepatic tissue and also increased serum lipid peroxidation. The highest dosage promoted the greatest incorporation of polyunsaturated fatty acids in the retroperitoneal adipose tissue. The biochemical parameters and serum inflammatory markers did not change. ConclusionGrape seed oil did not promote significant metabolic changes at either concentration but increased serum lipid peroxidation. 
publishDate 2023
dc.date.none.fl_str_mv 2023-03-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/8193
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/8193
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/8193/5715
dc.rights.driver.fl_str_mv Copyright (c) 2023 Fernanda Branco SHINAGAWA, Fernanda Carvalho de SANTANA, Jorge MANCINI-FILHO
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Fernanda Branco SHINAGAWA, Fernanda Carvalho de SANTANA, Jorge MANCINI-FILHO
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 28 No. 1 (2015): Revista de Nutrição
Revista de Nutrição; Vol. 28 Núm. 1 (2015): Revista de Nutrição
Revista de Nutrição; v. 28 n. 1 (2015): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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