Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Nutrição |
Texto Completo: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/8193 |
Resumo: | ObjectiveThe aim of this study was to evaluate the effect of long term consumption of cold-pressed grape seed oil purchased in Brazil on the biochemical and inflammatory biomarkers of healthy rats. MethodsWeaned and healthy Wistar rats received two concentrations (3 and 6 mL/kg body weight) of grape seed and soy oil for 65 days. The parameters studied were food intake and body, liver, brain, and retroperitoneal adipose tissue weight. The fatty acid composition of the adipose tissue was also determined. Serum biochemical parameters, lipid peroxidation, and inflammatory profile were assessed, quantifying the cytokines tumor necrosis factor alpha, interleukin 10 and IL-6. ResultsGrape seed oil, regardless of dosage, promoted much fat accumulation on hepatic tissue and also increased serum lipid peroxidation. The highest dosage promoted the greatest incorporation of polyunsaturated fatty acids in the retroperitoneal adipose tissue. The biochemical parameters and serum inflammatory markers did not change. ConclusionGrape seed oil did not promote significant metabolic changes at either concentration but increased serum lipid peroxidation. |
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Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profileEfeito do óleo de semente de uva prensado a frio nos marcadores bioquímicos e perfil inflamatório de ratosObjectiveThe aim of this study was to evaluate the effect of long term consumption of cold-pressed grape seed oil purchased in Brazil on the biochemical and inflammatory biomarkers of healthy rats. MethodsWeaned and healthy Wistar rats received two concentrations (3 and 6 mL/kg body weight) of grape seed and soy oil for 65 days. The parameters studied were food intake and body, liver, brain, and retroperitoneal adipose tissue weight. The fatty acid composition of the adipose tissue was also determined. Serum biochemical parameters, lipid peroxidation, and inflammatory profile were assessed, quantifying the cytokines tumor necrosis factor alpha, interleukin 10 and IL-6. ResultsGrape seed oil, regardless of dosage, promoted much fat accumulation on hepatic tissue and also increased serum lipid peroxidation. The highest dosage promoted the greatest incorporation of polyunsaturated fatty acids in the retroperitoneal adipose tissue. The biochemical parameters and serum inflammatory markers did not change. ConclusionGrape seed oil did not promote significant metabolic changes at either concentration but increased serum lipid peroxidation. ObjetivoO objetivo deste trabalho foi avaliar o efeito do consumo crônico do óleo de semente de uva, obtido do mercado brasileiro, nos marcadores bioquímicos e inflamatórios de ratos saudáveis. MétodosRatos Wistar, recém-desmamados e saudáveis, receberam por 65 dias óleo de semente de uva e soja em duas concentrações (3 e 6 mL/kg de peso corporal). Os parâmetros avaliados foram a ingestão alimentar, peso corporal e dos tecidos hepático, cerebral e adiposo retroperitonial; neste último, foi ainda realizado o perfil de ácidos graxos. A análise dos parâmetros bioquímicos, peroxidação lipídica e perfil inflamatório através da quantificação das citocinas TNF-α, IL-10 e IL-6 foi realizada no soro. ResultadosO óleo de semente de uva, independentemente da dose administrada, promoveu maior acúmulo de gordura no tecido hepático e aumento nos níveis de peroxidação lipídica do soro. Verificou-se que, quando consumido na maior dose, houve maior incorporação do ácido graxo linoleico no tecido adiposo retroperitonial. Modificações nos parâmetros bioquímicos e inflamatórios séricos não foram observadas. ConclusãoO consumo de óleo de semente de uva não provocou alterações metabólicas significantes em nenhuma das doses administradas ainda que se tenha observado uma elevação nos níveis de peroxidação lipídica sérica. Núcleo de Editoração – PUC-Campinas2023-03-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/8193Brazilian Journal of Nutrition; Vol. 28 No. 1 (2015): Revista de NutriçãoRevista de Nutrição; Vol. 28 Núm. 1 (2015): Revista de NutriçãoRevista de Nutrição; v. 28 n. 1 (2015): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/8193/5715Copyright (c) 2023 Fernanda Branco SHINAGAWA, Fernanda Carvalho de SANTANA, Jorge MANCINI-FILHOhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBranco SHINAGAWA, Fernanda Carvalho de SANTANA, Fernanda MANCINI-FILHO, Jorge2023-03-31T12:28:33Zoai:ojs.periodicos.puc-campinas.edu.br:article/8193Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-03-31T12:28:33Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile Efeito do óleo de semente de uva prensado a frio nos marcadores bioquímicos e perfil inflamatório de ratos |
title |
Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile |
spellingShingle |
Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile Branco SHINAGAWA, Fernanda |
title_short |
Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile |
title_full |
Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile |
title_fullStr |
Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile |
title_full_unstemmed |
Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile |
title_sort |
Effect of cold pressed grape seed oil on rats’ biochemical markers and inflammatory profile |
author |
Branco SHINAGAWA, Fernanda |
author_facet |
Branco SHINAGAWA, Fernanda Carvalho de SANTANA, Fernanda MANCINI-FILHO, Jorge |
author_role |
author |
author2 |
Carvalho de SANTANA, Fernanda MANCINI-FILHO, Jorge |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Branco SHINAGAWA, Fernanda Carvalho de SANTANA, Fernanda MANCINI-FILHO, Jorge |
description |
ObjectiveThe aim of this study was to evaluate the effect of long term consumption of cold-pressed grape seed oil purchased in Brazil on the biochemical and inflammatory biomarkers of healthy rats. MethodsWeaned and healthy Wistar rats received two concentrations (3 and 6 mL/kg body weight) of grape seed and soy oil for 65 days. The parameters studied were food intake and body, liver, brain, and retroperitoneal adipose tissue weight. The fatty acid composition of the adipose tissue was also determined. Serum biochemical parameters, lipid peroxidation, and inflammatory profile were assessed, quantifying the cytokines tumor necrosis factor alpha, interleukin 10 and IL-6. ResultsGrape seed oil, regardless of dosage, promoted much fat accumulation on hepatic tissue and also increased serum lipid peroxidation. The highest dosage promoted the greatest incorporation of polyunsaturated fatty acids in the retroperitoneal adipose tissue. The biochemical parameters and serum inflammatory markers did not change. ConclusionGrape seed oil did not promote significant metabolic changes at either concentration but increased serum lipid peroxidation. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-31 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/8193 |
url |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/8193 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/8193/5715 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2023 Fernanda Branco SHINAGAWA, Fernanda Carvalho de SANTANA, Jorge MANCINI-FILHO https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2023 Fernanda Branco SHINAGAWA, Fernanda Carvalho de SANTANA, Jorge MANCINI-FILHO https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Nutrition; Vol. 28 No. 1 (2015): Revista de Nutrição Revista de Nutrição; Vol. 28 Núm. 1 (2015): Revista de Nutrição Revista de Nutrição; v. 28 n. 1 (2015): Revista de Nutrição 1678-9865 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Revista de Nutrição |
collection |
Revista de Nutrição |
repository.name.fl_str_mv |
Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
||sbi.submissionrn@puc-campinas.edu.br |
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1799126069093072896 |