Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture

Detalhes bibliográficos
Autor(a) principal: Prais BOTELHO, Adriana
Data de Publicação: 2023
Outros Autores: Ferreira SANTOS-ZAGO, Lilia, Costa de OLIVEIRA (in memorian), Admar
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9530
Resumo: Supplementation with conjugated linoleic acid may reduce fat body mass and increase lean body mass in various species. Some studies have demonstrated that conjugated linoleic acid reduces body fat, in part, by inhibiting the activity of lipoprotein lipase in adipocytes. The objective of this work was to study the effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture. 3T3-L1 adipocytes received linoleic acid (group C) or conjugated linoleic acid (group AE,supplemented with AdvantEdge® CLA, and group CO, supplemented with CLA One®) in concentrations of 1 mmol/L. Heparin-releasable lipoprotein lipase activity was analyzed by means of a 3T3-L1 adipocyte culture. After 7 days, heparin-releasable lipoprotein lipase activity was lower in the groups AE and CO supplemented with conjugated linoleic acid. These results suggest that one of the mechanisms by which CLA is capable of reducing body fat is by reducing lipoprotein lipase activity.
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spelling Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte cultureEfeito da suplementação com ácido linoléico conjugado sobre a atividade da lípase lipoprotéica em cultura de adipócitos 3T3-L1Linoleic acid, conjugatedLipoprotein lipaseNutritionDietary supplementsÁcido linoléico conjugadoLípase lipoprotéicaNutriçãoSuplementos dietéticosSupplementation with conjugated linoleic acid may reduce fat body mass and increase lean body mass in various species. Some studies have demonstrated that conjugated linoleic acid reduces body fat, in part, by inhibiting the activity of lipoprotein lipase in adipocytes. The objective of this work was to study the effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture. 3T3-L1 adipocytes received linoleic acid (group C) or conjugated linoleic acid (group AE,supplemented with AdvantEdge® CLA, and group CO, supplemented with CLA One®) in concentrations of 1 mmol/L. Heparin-releasable lipoprotein lipase activity was analyzed by means of a 3T3-L1 adipocyte culture. After 7 days, heparin-releasable lipoprotein lipase activity was lower in the groups AE and CO supplemented with conjugated linoleic acid. These results suggest that one of the mechanisms by which CLA is capable of reducing body fat is by reducing lipoprotein lipase activity.A suplementação com ácido linoléico conjugado pode reduzir a gordura corporal e aumentar a massa magra em diferentes espécies. Alguns estudos têm demonstrado que o ácido linoléico conjugado reduz a gordura corporal, por meio da inibição da atividade de lípase lipoprotéica em adipócitos. O objetivo deste estudo foi avaliar o efeito da suplementação com uma mistura de isômeros do ácido linoléico conjugado sobre a atividade da lípase lipoprotéica em cultura de adipócitos 3T3-L1. Os adipócitos 3T3-L1 receberam ácido linoléico (grupo controle) ou ácido linoléico conjugado (grupo AE, suplementado com AdvantEdge® CLA, e grupo CO, suplementado com CLA One®) na concentração de 1 mmol/L. A atividade de lípase lipoprotéica livre de heparina foi analisada pela média da cultura de adipócitos. Após 7 dias, a atividade da lípase lipoprotéica livre de heparina mostrou menores valores nos grupos AE e CO, suplementados com ácido linoléico conjugado. Estes resultados sugerem que um dos mecanismos pelo qual o ácido linoléico conjugado seja capaz de reduzir a gordura corporal é a partir da redução da atividade da lípase lipoprotéica.Núcleo de Editoração – PUC-Campinas2023-08-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9530Brazilian Journal of Nutrition; Vol. 22 No. 5 (2009): Revista de NutriçãoRevista de Nutrição; Vol. 22 Núm. 5 (2009): Revista de NutriçãoRevista de Nutrição; v. 22 n. 5 (2009): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPenghttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9530/6897Copyright (c) 2023 Adriana Prais BOTELHO, Lilia Ferreira SANTOS-ZAGO, Admar Costa de OLIVEIRA (in memorian)https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessPrais BOTELHO, Adriana Ferreira SANTOS-ZAGO, Lilia Costa de OLIVEIRA (in memorian), Admar 2023-08-31T16:37:33Zoai:ojs.periodicos.puc-campinas.edu.br:article/9530Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-08-31T16:37:33Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture
Efeito da suplementação com ácido linoléico conjugado sobre a atividade da lípase lipoprotéica em cultura de adipócitos 3T3-L1
title Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture
spellingShingle Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture
Prais BOTELHO, Adriana
Linoleic acid, conjugated
Lipoprotein lipase
Nutrition
Dietary supplements
Ácido linoléico conjugado
Lípase lipoprotéica
Nutrição
Suplementos dietéticos
title_short Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture
title_full Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture
title_fullStr Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture
title_full_unstemmed Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture
title_sort Effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture
author Prais BOTELHO, Adriana
author_facet Prais BOTELHO, Adriana
Ferreira SANTOS-ZAGO, Lilia
Costa de OLIVEIRA (in memorian), Admar
author_role author
author2 Ferreira SANTOS-ZAGO, Lilia
Costa de OLIVEIRA (in memorian), Admar
author2_role author
author
dc.contributor.author.fl_str_mv Prais BOTELHO, Adriana
Ferreira SANTOS-ZAGO, Lilia
Costa de OLIVEIRA (in memorian), Admar
dc.subject.por.fl_str_mv Linoleic acid, conjugated
Lipoprotein lipase
Nutrition
Dietary supplements
Ácido linoléico conjugado
Lípase lipoprotéica
Nutrição
Suplementos dietéticos
topic Linoleic acid, conjugated
Lipoprotein lipase
Nutrition
Dietary supplements
Ácido linoléico conjugado
Lípase lipoprotéica
Nutrição
Suplementos dietéticos
description Supplementation with conjugated linoleic acid may reduce fat body mass and increase lean body mass in various species. Some studies have demonstrated that conjugated linoleic acid reduces body fat, in part, by inhibiting the activity of lipoprotein lipase in adipocytes. The objective of this work was to study the effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture. 3T3-L1 adipocytes received linoleic acid (group C) or conjugated linoleic acid (group AE,supplemented with AdvantEdge® CLA, and group CO, supplemented with CLA One®) in concentrations of 1 mmol/L. Heparin-releasable lipoprotein lipase activity was analyzed by means of a 3T3-L1 adipocyte culture. After 7 days, heparin-releasable lipoprotein lipase activity was lower in the groups AE and CO supplemented with conjugated linoleic acid. These results suggest that one of the mechanisms by which CLA is capable of reducing body fat is by reducing lipoprotein lipase activity.
publishDate 2023
dc.date.none.fl_str_mv 2023-08-31
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9530
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9530
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9530/6897
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 22 No. 5 (2009): Revista de Nutrição
Revista de Nutrição; Vol. 22 Núm. 5 (2009): Revista de Nutrição
Revista de Nutrição; v. 22 n. 5 (2009): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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