Infl uence of protein malnutrition on cutaneous wound healing in rats
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Nutrição |
Texto Completo: | https://periodicos.puc-campinas.edu.br/nutricao/article/view/7688 |
Resumo: | ObjectiveInvestigate histological changes related to infl ammatory response and collagen expression during wound healing in rats with protein malnutrition. MethodsTwenty male Wistar rats underwent cutaneous surgery and were divided into two experimental groups: Malnourished (8% casein diet); Nourished (17% casein diet). Animals were euthanized after 5th and 10th days, descriptive and quantitative analyses were performed on sections stained with hematoxylin-eosin and sirius red, respectively. Statistical analysis of data using nonparametric Fisher's exact test with p<0.05 was carried out. ResultsAt fi ve days, increased fi broblast proliferation (p<0.01) and collagen expression (p<0.05) was observed in N5 group. After ten days, N10 and MN10 animals showed higher amount of granulation tissue and edema/infl ammatory infi ltrate independent of nutritional status (p>0.05), only N10 group showed fi broblast proliferation (p<0.01) and increased collagen expression (p<0.01). ConclusionProtein malnutrition seems not to influence inflammatory phase of healing, whereas it negatively effects fibroblast proliferation and collagen synthesis. |
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Revista de Nutrição |
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Infl uence of protein malnutrition on cutaneous wound healing in ratsCollagenMalnutritionProtein malnutritionWound healingObjectiveInvestigate histological changes related to infl ammatory response and collagen expression during wound healing in rats with protein malnutrition. MethodsTwenty male Wistar rats underwent cutaneous surgery and were divided into two experimental groups: Malnourished (8% casein diet); Nourished (17% casein diet). Animals were euthanized after 5th and 10th days, descriptive and quantitative analyses were performed on sections stained with hematoxylin-eosin and sirius red, respectively. Statistical analysis of data using nonparametric Fisher's exact test with p<0.05 was carried out. ResultsAt fi ve days, increased fi broblast proliferation (p<0.01) and collagen expression (p<0.05) was observed in N5 group. After ten days, N10 and MN10 animals showed higher amount of granulation tissue and edema/infl ammatory infi ltrate independent of nutritional status (p>0.05), only N10 group showed fi broblast proliferation (p<0.01) and increased collagen expression (p<0.01). ConclusionProtein malnutrition seems not to influence inflammatory phase of healing, whereas it negatively effects fibroblast proliferation and collagen synthesis.Núcleo de Editoração – PUC-Campinas2023-03-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/7688Brazilian Journal of Nutrition; Vol. 31 No. 5 (2018): Revista de NutriçãoRevista de Nutrição; Vol. 31 Núm. 5 (2018): Revista de NutriçãoRevista de Nutrição; v. 31 n. 5 (2018): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/7688/5224Copyright (c) 2023 Laura Amélia Santos SAMPAIO, Jéssica Santos COSTA, Tila Fortuna Costa FREIRE, Sílvia Regina de Almeida REIS, Tereza Cristina Bomfi m de Jesus DEIRÓ, Alena Ribeiro Alves Peixoto MEDRADOhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos SAMPAIO, Laura Amélia Santos COSTA, Jéssica Fortuna Costa FREIRE, Tila de Almeida REIS, Sílvia Regina Bomfi m de Jesus DEIRÓ, Tereza Cristina Ribeiro Alves Peixoto MEDRADO, Alena 2023-03-08T18:27:59Zoai:ojs.periodicos.puc-campinas.edu.br:article/7688Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-03-08T18:27:59Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
Infl uence of protein malnutrition on cutaneous wound healing in rats |
title |
Infl uence of protein malnutrition on cutaneous wound healing in rats |
spellingShingle |
Infl uence of protein malnutrition on cutaneous wound healing in rats Santos SAMPAIO, Laura Amélia Collagen Malnutrition Protein malnutrition Wound healing |
title_short |
Infl uence of protein malnutrition on cutaneous wound healing in rats |
title_full |
Infl uence of protein malnutrition on cutaneous wound healing in rats |
title_fullStr |
Infl uence of protein malnutrition on cutaneous wound healing in rats |
title_full_unstemmed |
Infl uence of protein malnutrition on cutaneous wound healing in rats |
title_sort |
Infl uence of protein malnutrition on cutaneous wound healing in rats |
author |
Santos SAMPAIO, Laura Amélia |
author_facet |
Santos SAMPAIO, Laura Amélia Santos COSTA, Jéssica Fortuna Costa FREIRE, Tila de Almeida REIS, Sílvia Regina Bomfi m de Jesus DEIRÓ, Tereza Cristina Ribeiro Alves Peixoto MEDRADO, Alena |
author_role |
author |
author2 |
Santos COSTA, Jéssica Fortuna Costa FREIRE, Tila de Almeida REIS, Sílvia Regina Bomfi m de Jesus DEIRÓ, Tereza Cristina Ribeiro Alves Peixoto MEDRADO, Alena |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Santos SAMPAIO, Laura Amélia Santos COSTA, Jéssica Fortuna Costa FREIRE, Tila de Almeida REIS, Sílvia Regina Bomfi m de Jesus DEIRÓ, Tereza Cristina Ribeiro Alves Peixoto MEDRADO, Alena |
dc.subject.por.fl_str_mv |
Collagen Malnutrition Protein malnutrition Wound healing |
topic |
Collagen Malnutrition Protein malnutrition Wound healing |
description |
ObjectiveInvestigate histological changes related to infl ammatory response and collagen expression during wound healing in rats with protein malnutrition. MethodsTwenty male Wistar rats underwent cutaneous surgery and were divided into two experimental groups: Malnourished (8% casein diet); Nourished (17% casein diet). Animals were euthanized after 5th and 10th days, descriptive and quantitative analyses were performed on sections stained with hematoxylin-eosin and sirius red, respectively. Statistical analysis of data using nonparametric Fisher's exact test with p<0.05 was carried out. ResultsAt fi ve days, increased fi broblast proliferation (p<0.01) and collagen expression (p<0.05) was observed in N5 group. After ten days, N10 and MN10 animals showed higher amount of granulation tissue and edema/infl ammatory infi ltrate independent of nutritional status (p>0.05), only N10 group showed fi broblast proliferation (p<0.01) and increased collagen expression (p<0.01). ConclusionProtein malnutrition seems not to influence inflammatory phase of healing, whereas it negatively effects fibroblast proliferation and collagen synthesis. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-08 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/7688 |
url |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/7688 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://periodicos.puc-campinas.edu.br/nutricao/article/view/7688/5224 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
publisher.none.fl_str_mv |
Núcleo de Editoração – PUC-Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Nutrition; Vol. 31 No. 5 (2018): Revista de Nutrição Revista de Nutrição; Vol. 31 Núm. 5 (2018): Revista de Nutrição Revista de Nutrição; v. 31 n. 5 (2018): Revista de Nutrição 1678-9865 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Revista de Nutrição |
collection |
Revista de Nutrição |
repository.name.fl_str_mv |
Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
||sbi.submissionrn@puc-campinas.edu.br |
_version_ |
1799126067885113344 |