The impact of polyphenols-based diet on the inflammatory profile in COVID-19 elderly and obese patients
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional PUC-Campinas |
Texto Completo: | http://repositorio.sis.puc-campinas.edu.br/xmlui/handle/123456789/17229 |
Resumo: | The World Health Organization declared the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-associated disease (coronavirus disease 2019 – COVID-19) as a pandemic in March 2020. COVID-19 is characterized by cytokine storm, acute respiratory distress syndrome (ARDS), and systemic inflammation–related pathology and already kills more than 1.5 million of people worldwide. Since aged and obese COVID-19 patients exhibit an enhanced inflammatory status, they represent a high-risk cluster for rapidly progressive clinical deterioration. These individuals present comorbid disorders and immunosenescence that may promote viral-induced cytokine storm and expression of molecules acting as virus receptor as angiotensin I converting enzyme 2 (ACE2) and CD26 (dipeptidyl-peptidase 4), resulting in respiratory failure and increased morbidity and mortality. A better knowledge of SARS-CoV-2 infection in inflammatory-associated high-risk population is essential in order to develop the therapies needed to combat or prevent severe COVID-19. Here, we review the pathogenesis and clinical implications of inflammatory disorders and disease markers associated to senescence in COVID-19 patients and the emerging evidence to argue that a high intake of polyphenols may have a protective effect on SARS-CoV-2 illness severity. |
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The impact of polyphenols-based diet on the inflammatory profile in COVID-19 elderly and obese patientsO impacto da dieta à base de polifenóis no perfil inflamatório em pacientes idosos e obesos com COVID-19COVID-19cytokine storminflammationsenescencepolyphenolsThe World Health Organization declared the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-associated disease (coronavirus disease 2019 – COVID-19) as a pandemic in March 2020. COVID-19 is characterized by cytokine storm, acute respiratory distress syndrome (ARDS), and systemic inflammation–related pathology and already kills more than 1.5 million of people worldwide. Since aged and obese COVID-19 patients exhibit an enhanced inflammatory status, they represent a high-risk cluster for rapidly progressive clinical deterioration. These individuals present comorbid disorders and immunosenescence that may promote viral-induced cytokine storm and expression of molecules acting as virus receptor as angiotensin I converting enzyme 2 (ACE2) and CD26 (dipeptidyl-peptidase 4), resulting in respiratory failure and increased morbidity and mortality. A better knowledge of SARS-CoV-2 infection in inflammatory-associated high-risk population is essential in order to develop the therapies needed to combat or prevent severe COVID-19. Here, we review the pathogenesis and clinical implications of inflammatory disorders and disease markers associated to senescence in COVID-19 patients and the emerging evidence to argue that a high intake of polyphenols may have a protective effect on SARS-CoV-2 illness severity.Frontiers in PhysiologyPontifícia Universidade Católica de Campinas (PUC-Campinas)Santos, Juliana CarvalhoRibeiro, Marcelo LimaGambero, Alessandra2024-03-27T13:58:50Z2024-03-27T13:58:50Z2021-01-12info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://repositorio.sis.puc-campinas.edu.br/xmlui/handle/123456789/17229374513036797821039072102350814837165708428659026enginfo:eu-repo/semantics/openAccessreponame:Repositório Institucional PUC-Campinasinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMP2024-03-27T13:58:50Zoai:repositorio.sis.puc-campinas.edu.br:123456789/17229Repositório InstitucionalPRIhttps://repositorio.sis.puc-campinas.edu.br/oai/requestsbi.bibliotecadigital@puc-campinas.edu.bropendoar:2024-03-27T13:58:50Repositório Institucional PUC-Campinas - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
The impact of polyphenols-based diet on the inflammatory profile in COVID-19 elderly and obese patients O impacto da dieta à base de polifenóis no perfil inflamatório em pacientes idosos e obesos com COVID-19 |
title |
The impact of polyphenols-based diet on the inflammatory profile in COVID-19 elderly and obese patients |
spellingShingle |
The impact of polyphenols-based diet on the inflammatory profile in COVID-19 elderly and obese patients Santos, Juliana Carvalho COVID-19 cytokine storm inflammation senescence polyphenols |
title_short |
The impact of polyphenols-based diet on the inflammatory profile in COVID-19 elderly and obese patients |
title_full |
The impact of polyphenols-based diet on the inflammatory profile in COVID-19 elderly and obese patients |
title_fullStr |
The impact of polyphenols-based diet on the inflammatory profile in COVID-19 elderly and obese patients |
title_full_unstemmed |
The impact of polyphenols-based diet on the inflammatory profile in COVID-19 elderly and obese patients |
title_sort |
The impact of polyphenols-based diet on the inflammatory profile in COVID-19 elderly and obese patients |
author |
Santos, Juliana Carvalho |
author_facet |
Santos, Juliana Carvalho Ribeiro, Marcelo Lima Gambero, Alessandra |
author_role |
author |
author2 |
Ribeiro, Marcelo Lima Gambero, Alessandra |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Pontifícia Universidade Católica de Campinas (PUC-Campinas) |
dc.contributor.author.fl_str_mv |
Santos, Juliana Carvalho Ribeiro, Marcelo Lima Gambero, Alessandra |
dc.subject.por.fl_str_mv |
COVID-19 cytokine storm inflammation senescence polyphenols |
topic |
COVID-19 cytokine storm inflammation senescence polyphenols |
description |
The World Health Organization declared the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-associated disease (coronavirus disease 2019 – COVID-19) as a pandemic in March 2020. COVID-19 is characterized by cytokine storm, acute respiratory distress syndrome (ARDS), and systemic inflammation–related pathology and already kills more than 1.5 million of people worldwide. Since aged and obese COVID-19 patients exhibit an enhanced inflammatory status, they represent a high-risk cluster for rapidly progressive clinical deterioration. These individuals present comorbid disorders and immunosenescence that may promote viral-induced cytokine storm and expression of molecules acting as virus receptor as angiotensin I converting enzyme 2 (ACE2) and CD26 (dipeptidyl-peptidase 4), resulting in respiratory failure and increased morbidity and mortality. A better knowledge of SARS-CoV-2 infection in inflammatory-associated high-risk population is essential in order to develop the therapies needed to combat or prevent severe COVID-19. Here, we review the pathogenesis and clinical implications of inflammatory disorders and disease markers associated to senescence in COVID-19 patients and the emerging evidence to argue that a high intake of polyphenols may have a protective effect on SARS-CoV-2 illness severity. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-12 2024-03-27T13:58:50Z 2024-03-27T13:58:50Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://repositorio.sis.puc-campinas.edu.br/xmlui/handle/123456789/17229 3745130367978210 3907210235081483 7165708428659026 |
url |
http://repositorio.sis.puc-campinas.edu.br/xmlui/handle/123456789/17229 |
identifier_str_mv |
3745130367978210 3907210235081483 7165708428659026 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers in Physiology |
publisher.none.fl_str_mv |
Frontiers in Physiology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional PUC-Campinas instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Repositório Institucional PUC-Campinas |
collection |
Repositório Institucional PUC-Campinas |
repository.name.fl_str_mv |
Repositório Institucional PUC-Campinas - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
sbi.bibliotecadigital@puc-campinas.edu.br |
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