Will a little change do you good? A putative role of polymorphisms in COVID-19

Detalhes bibliográficos
Autor(a) principal: Paim, Adriana Alves Oliveira
Data de Publicação: 2021
Outros Autores: Ribeiro, Ágata Lopes, Silva, Danielle Soares de Oliveira Daian e, Andrade, Luis Adan Flores, Moraes, Thaís de Fátima Silva, Stancioli, Edel Figueiredo Barbosa, Fonseca, Flávio Guimarães da, Reis, Jordana Grazziela Alves Coelho dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.imlet.2021.04.005
Texto Completo: https://www.arca.fiocruz.br/handle/icict/52019
Resumo: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil.
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spelling Paim, Adriana Alves OliveiraRibeiro, Ágata LopesSilva, Danielle Soares de Oliveira Daian eAndrade, Luis Adan FloresMoraes, Thaís de Fátima SilvaStancioli, Edel Figueiredo BarbosaFonseca, Flávio Guimarães daReis, Jordana Grazziela Alves Coelho dos2022-04-04T18:03:48Z2022-04-04T18:03:48Z2021PAIM, Adriana Alves Oliveira et al. Will a little change do you good? A putative role of polymorphisms in COVID-19. Immunol Lett, v. 235, p. 9-14, 2021. doi: 10.1016/j.imlet.2021.04.005.0165-2478https://www.arca.fiocruz.br/handle/icict/5201910.1016/j.imlet.2021.04.005engElsevier/North-Holland Biomedical PressWill a little change do you good? A putative role of polymorphisms in COVID-19info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil./Biomarkers Research Group. René Rachou Institute. Osvaldo Cruz Foundation. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. CT Vacinas, BH-TEC. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. CT Vacinas, BH-TEC. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil/ Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. CT Vacinas, BH-TEC. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil./Biomarkers Research Group. René Rachou Institute. Osvaldo Cruz Foundation. Belo Horizonte, MG, Brazil.An alarming disease caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) named COVID-19 has emerged as an unprecedented public health problem and ignited a world health crisis. As opposed to what was believed at the beginning of the pandemic, the virus has not only spread but persevere causing secondary waves and challenging the concept of herd immunity against viral infections. While the majority of SARS-CoV-2-infected individuals may remain asymptomatic, a fraction of individuals may develop low to high-grade severity signs and symptoms of COVID-19. The disease is multifactorial and can progress quickly, leading to severe complications and even death in a few days. Therefore, understanding the pre-existing factors for disease development has never been so pressing. In this scenario, the insights on the mechanisms underlying disease allied to the immune response developed during the viral invasion could shed light on novel predictive factors and prognostic tools for COVID-19 management and interventions. A recent genome-wide association study (GWAS) revealed several molecules that significantly impacted critically ill COVID-19 patients, leading to the core mechanisms of COVID-19 pathogenesis. Considering these findings and the fact that ACE-2 polymorphisms alone cannot explain disease progress and severity, this review aims at summarizing the most important and recent findings of the research and expert consensus of possible cytokine-related polymorphisms existing in the differential expression of paramount immune molecules that could be crucial for providing guidelines for decision-making and appropriate clinical management of COVID-19.Cytokine stormPolymorphismSARSSARS-CoV-2info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/52019/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALWill a little change do you good.pdfWill a little change do you good.pdfapplication/pdf756253https://www.arca.fiocruz.br/bitstream/icict/52019/2/Will%20a%20little%20change%20do%20you%20good.pdfd68319a2bc8c858b77f6f82aa1afb8adMD52icict/520192022-04-04 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dc.title.pt_BR.fl_str_mv Will a little change do you good? A putative role of polymorphisms in COVID-19
title Will a little change do you good? A putative role of polymorphisms in COVID-19
spellingShingle Will a little change do you good? A putative role of polymorphisms in COVID-19
Paim, Adriana Alves Oliveira
Cytokine storm
Polymorphism
SARS
SARS-CoV-2
title_short Will a little change do you good? A putative role of polymorphisms in COVID-19
title_full Will a little change do you good? A putative role of polymorphisms in COVID-19
title_fullStr Will a little change do you good? A putative role of polymorphisms in COVID-19
title_full_unstemmed Will a little change do you good? A putative role of polymorphisms in COVID-19
title_sort Will a little change do you good? A putative role of polymorphisms in COVID-19
author Paim, Adriana Alves Oliveira
author_facet Paim, Adriana Alves Oliveira
Ribeiro, Ágata Lopes
Silva, Danielle Soares de Oliveira Daian e
Andrade, Luis Adan Flores
Moraes, Thaís de Fátima Silva
Stancioli, Edel Figueiredo Barbosa
Fonseca, Flávio Guimarães da
Reis, Jordana Grazziela Alves Coelho dos
author_role author
author2 Ribeiro, Ágata Lopes
Silva, Danielle Soares de Oliveira Daian e
Andrade, Luis Adan Flores
Moraes, Thaís de Fátima Silva
Stancioli, Edel Figueiredo Barbosa
Fonseca, Flávio Guimarães da
Reis, Jordana Grazziela Alves Coelho dos
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Paim, Adriana Alves Oliveira
Ribeiro, Ágata Lopes
Silva, Danielle Soares de Oliveira Daian e
Andrade, Luis Adan Flores
Moraes, Thaís de Fátima Silva
Stancioli, Edel Figueiredo Barbosa
Fonseca, Flávio Guimarães da
Reis, Jordana Grazziela Alves Coelho dos
dc.subject.en.pt_BR.fl_str_mv Cytokine storm
Polymorphism
SARS
SARS-CoV-2
topic Cytokine storm
Polymorphism
SARS
SARS-CoV-2
description Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-04-04T18:03:48Z
dc.date.available.fl_str_mv 2022-04-04T18:03:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PAIM, Adriana Alves Oliveira et al. Will a little change do you good? A putative role of polymorphisms in COVID-19. Immunol Lett, v. 235, p. 9-14, 2021. doi: 10.1016/j.imlet.2021.04.005.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/52019
dc.identifier.issn.pt_BR.fl_str_mv 0165-2478
dc.identifier.doi.none.fl_str_mv 10.1016/j.imlet.2021.04.005
identifier_str_mv PAIM, Adriana Alves Oliveira et al. Will a little change do you good? A putative role of polymorphisms in COVID-19. Immunol Lett, v. 235, p. 9-14, 2021. doi: 10.1016/j.imlet.2021.04.005.
0165-2478
10.1016/j.imlet.2021.04.005
url https://www.arca.fiocruz.br/handle/icict/52019
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier/North-Holland Biomedical Press
publisher.none.fl_str_mv Elsevier/North-Holland Biomedical Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/52019/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/52019/2/Will%20a%20little%20change%20do%20you%20good.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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