Bisphosphonates and jaw osteonecrosis

Detalhes bibliográficos
Autor(a) principal: Maahs, Marcia Angelica Peter
Data de Publicação: 2009
Outros Autores: Nora, Vanessa Paim, Azambuja, Alan Arrieira, Cherubini, Karen
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista odonto ciência (Online)
Texto Completo: https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4960
Resumo: Bisphosphonates have been widely prescribed for treatment of diseases characterized by intense bone resorption. These drugs have also been associated with a serious side effect, avascular osteonecrosis of the jaws. The authors present a literature review on bisphosphonates, focusing on their pharmacological features and their reported association with jaw osteonecrosis. The morbidity and lack of treatment response of this condition are serious facts to be considered when prescribing bisphosphonate therapy. The risk-benefit relationship needs to be seriously analyzed, and the treatment pros and cons should be explained to the patient. If the therapy with bisphosphonate is indicated, rigorous oral health adequacy must be performed and periodic evaluation of oral conditions is mandatory. At this moment, caution in treatment seems to be the best way to approach bisphosphonate users.
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spelling Bisphosphonates and jaw osteonecrosisBisfosfonatos e osteonecrose dos maxilaresBisphosphonatesosteonecrosisjawOral MedicineOral BiologyBisphosphonates have been widely prescribed for treatment of diseases characterized by intense bone resorption. These drugs have also been associated with a serious side effect, avascular osteonecrosis of the jaws. The authors present a literature review on bisphosphonates, focusing on their pharmacological features and their reported association with jaw osteonecrosis. The morbidity and lack of treatment response of this condition are serious facts to be considered when prescribing bisphosphonate therapy. The risk-benefit relationship needs to be seriously analyzed, and the treatment pros and cons should be explained to the patient. If the therapy with bisphosphonate is indicated, rigorous oral health adequacy must be performed and periodic evaluation of oral conditions is mandatory. At this moment, caution in treatment seems to be the best way to approach bisphosphonate users.Os bisfosfonatos têm sido amplamente empregados no tratamento de enfermidades cuja característica principal é a intensa reabsorção óssea. Tais drogas também têm sido associadas a um importante efeito colateral – a osteonecrose avascular dos maxilares. Os autores apresentam uma revisão da literatura sobre bisfosfonatos, enfocando aspectos farmacológicos e a osteonecrose dos maxilares. A morbidade e a falta de resposta ao tratamento desta condição são fatores importantes a serem considerados na prescrição de terapia com bisfosfonatos. A relação risco-benefício precisa ser seriamente analisada, e os prós e contras do tratamento devem ser explicados ao paciente. Se a terapia for indicada, uma rigorosa adequação bucal deve ser realizada e o paciente necessita ser periodicamente avaliado. No presente momento, a precaução parece ser o melhor modo de abordar os usuários de bisfosfonatos.EDIPUCRS - Editora Universitária da PUCRS2009-03-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionInvited Articleinfo:eu-repo/semantics/otherapplication/pdfhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4960Revista Odonto Ciência; Vol. 24 No. 4 (2009); 337 - 344Revista Odonto Ciência; v. 24 n. 4 (2009); 337 - 3441980-65230102-9460reponame:Revista odonto ciência (Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4960/4771Maahs, Marcia Angelica PeterNora, Vanessa PaimAzambuja, Alan ArrieiraCherubini, Kareninfo:eu-repo/semantics/openAccess2013-11-11T12:57:32Zoai:ojs.revistaseletronicas.pucrs.br:article/4960Revistahttps://revistaseletronicas.pucrs.br/ojs/index.php/foPRIhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/oai||odontociencia@pucrs.br1980-65230102-9460opendoar:2013-11-11T12:57:32Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Bisphosphonates and jaw osteonecrosis
Bisfosfonatos e osteonecrose dos maxilares
title Bisphosphonates and jaw osteonecrosis
spellingShingle Bisphosphonates and jaw osteonecrosis
Maahs, Marcia Angelica Peter
Bisphosphonates
osteonecrosis
jaw
Oral Medicine
Oral Biology
title_short Bisphosphonates and jaw osteonecrosis
title_full Bisphosphonates and jaw osteonecrosis
title_fullStr Bisphosphonates and jaw osteonecrosis
title_full_unstemmed Bisphosphonates and jaw osteonecrosis
title_sort Bisphosphonates and jaw osteonecrosis
author Maahs, Marcia Angelica Peter
author_facet Maahs, Marcia Angelica Peter
Nora, Vanessa Paim
Azambuja, Alan Arrieira
Cherubini, Karen
author_role author
author2 Nora, Vanessa Paim
Azambuja, Alan Arrieira
Cherubini, Karen
author2_role author
author
author
dc.contributor.author.fl_str_mv Maahs, Marcia Angelica Peter
Nora, Vanessa Paim
Azambuja, Alan Arrieira
Cherubini, Karen
dc.subject.por.fl_str_mv Bisphosphonates
osteonecrosis
jaw
Oral Medicine
Oral Biology
topic Bisphosphonates
osteonecrosis
jaw
Oral Medicine
Oral Biology
description Bisphosphonates have been widely prescribed for treatment of diseases characterized by intense bone resorption. These drugs have also been associated with a serious side effect, avascular osteonecrosis of the jaws. The authors present a literature review on bisphosphonates, focusing on their pharmacological features and their reported association with jaw osteonecrosis. The morbidity and lack of treatment response of this condition are serious facts to be considered when prescribing bisphosphonate therapy. The risk-benefit relationship needs to be seriously analyzed, and the treatment pros and cons should be explained to the patient. If the therapy with bisphosphonate is indicated, rigorous oral health adequacy must be performed and periodic evaluation of oral conditions is mandatory. At this moment, caution in treatment seems to be the best way to approach bisphosphonate users.
publishDate 2009
dc.date.none.fl_str_mv 2009-03-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Invited Article
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4960
url https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4960
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/4960/4771
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv EDIPUCRS - Editora Universitária da PUCRS
publisher.none.fl_str_mv EDIPUCRS - Editora Universitária da PUCRS
dc.source.none.fl_str_mv Revista Odonto Ciência; Vol. 24 No. 4 (2009); 337 - 344
Revista Odonto Ciência; v. 24 n. 4 (2009); 337 - 344
1980-6523
0102-9460
reponame:Revista odonto ciência (Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Revista odonto ciência (Online)
collection Revista odonto ciência (Online)
repository.name.fl_str_mv Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv ||odontociencia@pucrs.br
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