The role of immune system in the development of periodontal disease: a brief review

Detalhes bibliográficos
Autor(a) principal: Mariano, Flávia Sammartino
Data de Publicação: 2010
Outros Autores: Sardi, Janaina de Cássia Orlandi, Duque, Cristiane, Höfling, José Francisco, Gonçalves, Reginaldo Bruno
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista odonto ciência (Online)
Texto Completo: https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/6584
Resumo: Periodontitis is a highly complex and multi-factorial disease. This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. Although several studies have tried to clarify some of the immune mechanisms involved in periodontal disease, more studies must be conducted to understand its development and progression and consequently to discover new alternatives for the prevention and treatment of this severe inflammatory disease.
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spelling The role of immune system in the development of periodontal disease: a brief reviewO papel do sistema imune no desenvolvimento da doença periodontal: uma breve revisãoImmunologyperiodontitiscytokineschemotaxisantibodiesImunologiaperiodontitecitocinasquimiotaxisanticorposPeriodontitePeriodontitis is a highly complex and multi-factorial disease. This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. Although several studies have tried to clarify some of the immune mechanisms involved in periodontal disease, more studies must be conducted to understand its development and progression and consequently to discover new alternatives for the prevention and treatment of this severe inflammatory disease.A periodontite é uma doença altamente complexa e multifatorial. Esta breve revisão reúne alguns fatores imunológicos envolvidos no desenvolvimento e controle desta doença oral, tais como: a participação de células inflamatórias no local da inflamação, a síntese de proteínas quimiotáticas através da ativação do sistema complemento e a presença de alguns dos peptídeos antimicrobianos, como defensinas, catelicidinas e saposinas. A interação de padrões moleculares associados à patógenos (PAMPs) de microrganismos com seus receptores de superfície, em células imunológicas, induz a produção de várias citocinas e quimiocinas que apresentam função pró- e/ou anti-inflamatória estimulando a secreção de uma grande variedade de subtipos de anticorpos e a ativação de mecanismos de controle da doença, como as células T reguladoras. Embora vários trabalhos tentem esclarecer alguns dos mecanismos imunológicos envolvidos na doença periodontal, estudos adicionais são necessários para ampliar conhecimentos sobre o desenvolvimento, a progressão e, consequentemente, para se descobrir novas alternativas de prevenção e tratamento desta grave doença inflamatória.EDIPUCRS - Editora Universitária da PUCRS2010-08-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Article. Invited Article.revisão de literaturainfo:eu-repo/semantics/otherapplication/pdfhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/6584Revista Odonto Ciência; Vol. 25 No. 3 (2010); 300 - 305Revista Odonto Ciência; v. 25 n. 3 (2010); 300 - 3051980-65230102-9460reponame:Revista odonto ciência (Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/6584/5553Mariano, Flávia SammartinoSardi, Janaina de Cássia OrlandiDuque, CristianeHöfling, José FranciscoGonçalves, Reginaldo Brunoinfo:eu-repo/semantics/openAccess2013-11-11T12:30:19Zoai:ojs.revistaseletronicas.pucrs.br:article/6584Revistahttps://revistaseletronicas.pucrs.br/ojs/index.php/foPRIhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/oai||odontociencia@pucrs.br1980-65230102-9460opendoar:2013-11-11T12:30:19Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv The role of immune system in the development of periodontal disease: a brief review
O papel do sistema imune no desenvolvimento da doença periodontal: uma breve revisão
title The role of immune system in the development of periodontal disease: a brief review
spellingShingle The role of immune system in the development of periodontal disease: a brief review
Mariano, Flávia Sammartino
Immunology
periodontitis
cytokines
chemotaxis
antibodies
Imunologia
periodontite
citocinas
quimiotaxis
anticorpos
Periodontite
title_short The role of immune system in the development of periodontal disease: a brief review
title_full The role of immune system in the development of periodontal disease: a brief review
title_fullStr The role of immune system in the development of periodontal disease: a brief review
title_full_unstemmed The role of immune system in the development of periodontal disease: a brief review
title_sort The role of immune system in the development of periodontal disease: a brief review
author Mariano, Flávia Sammartino
author_facet Mariano, Flávia Sammartino
Sardi, Janaina de Cássia Orlandi
Duque, Cristiane
Höfling, José Francisco
Gonçalves, Reginaldo Bruno
author_role author
author2 Sardi, Janaina de Cássia Orlandi
Duque, Cristiane
Höfling, José Francisco
Gonçalves, Reginaldo Bruno
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Mariano, Flávia Sammartino
Sardi, Janaina de Cássia Orlandi
Duque, Cristiane
Höfling, José Francisco
Gonçalves, Reginaldo Bruno
dc.subject.por.fl_str_mv Immunology
periodontitis
cytokines
chemotaxis
antibodies
Imunologia
periodontite
citocinas
quimiotaxis
anticorpos
Periodontite
topic Immunology
periodontitis
cytokines
chemotaxis
antibodies
Imunologia
periodontite
citocinas
quimiotaxis
anticorpos
Periodontite
description Periodontitis is a highly complex and multi-factorial disease. This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. Although several studies have tried to clarify some of the immune mechanisms involved in periodontal disease, more studies must be conducted to understand its development and progression and consequently to discover new alternatives for the prevention and treatment of this severe inflammatory disease.
publishDate 2010
dc.date.none.fl_str_mv 2010-08-17
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article. Invited Article.
revisão de literatura
info:eu-repo/semantics/other
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/6584
url https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/6584
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/6584/5553
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv EDIPUCRS - Editora Universitária da PUCRS
publisher.none.fl_str_mv EDIPUCRS - Editora Universitária da PUCRS
dc.source.none.fl_str_mv Revista Odonto Ciência; Vol. 25 No. 3 (2010); 300 - 305
Revista Odonto Ciência; v. 25 n. 3 (2010); 300 - 305
1980-6523
0102-9460
reponame:Revista odonto ciência (Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Revista odonto ciência (Online)
collection Revista odonto ciência (Online)
repository.name.fl_str_mv Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv ||odontociencia@pucrs.br
_version_ 1754820875362762752

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