Tissue inflammatory response to implantation of calcium hydroxide and iodoform in the back of rats

Detalhes bibliográficos
Autor(a) principal: Pallotta, Raul Capp
Data de Publicação: 2010
Outros Autores: Machado, Manoel Eduardo de Lima, Reis, Norair Salviano dos, Martins, Guilherme Henrique Rosa, Nabeshima, Cleber Keiti
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista odonto ciência (Online)
Texto Completo: https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/5862
Resumo: Purpose: This study evaluated the inflammatory reaction caused by the implantation of iodoform and calcium hydroxide in the back of rats. These drugs may be used as intracanal dressings to eliminate residual bacteria of the root canal system. Methods: Twenty albinic rats (Rattus norvegicus, var Wistar) were divided into four groups: control group 1 (CG1) had normal skin; control group 2 (CG2) had wounded tissue without drugs; in groups 3 and 4, iodoform (IG) and calcium hydroxide (CHG) were inserted into the wounds, respectively. After 3, 5 and 11 days, slices of the implanted areas were macroscopically and microscopically observed regarding to their qualitative and quantitative aspects. Results: In the macroscopical analysis, the CHG showed a large area of necrosis and swelling, which progressively decreased; in the IG the presence of iodoform surrounded by normal tissue was observed. The qualitative and quantitative histological analysis showed that IG promoted a shorter delay in the inflammatory response than the CHG. Conclusion: The inflammatory reaction for iodoform had a peak period five days after the drug insertion. By comparison, calcium hydroxide showed a very large area of necrosis that could only be partially eliminated after eleven days.
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spelling Tissue inflammatory response to implantation of calcium hydroxide and iodoform in the back of ratsResposta inflamatória tecidual da implantação de hidróxido de cálcio e iodofórmio em dorso de ratosCalcium hydroxideEndodonticsinflammationiodoformPurpose: This study evaluated the inflammatory reaction caused by the implantation of iodoform and calcium hydroxide in the back of rats. These drugs may be used as intracanal dressings to eliminate residual bacteria of the root canal system. Methods: Twenty albinic rats (Rattus norvegicus, var Wistar) were divided into four groups: control group 1 (CG1) had normal skin; control group 2 (CG2) had wounded tissue without drugs; in groups 3 and 4, iodoform (IG) and calcium hydroxide (CHG) were inserted into the wounds, respectively. After 3, 5 and 11 days, slices of the implanted areas were macroscopically and microscopically observed regarding to their qualitative and quantitative aspects. Results: In the macroscopical analysis, the CHG showed a large area of necrosis and swelling, which progressively decreased; in the IG the presence of iodoform surrounded by normal tissue was observed. The qualitative and quantitative histological analysis showed that IG promoted a shorter delay in the inflammatory response than the CHG. Conclusion: The inflammatory reaction for iodoform had a peak period five days after the drug insertion. By comparison, calcium hydroxide showed a very large area of necrosis that could only be partially eliminated after eleven days.Objetivo: O objetivo deste estudo foi avaliar a resposta inflamatória causada pela implantação do iodofórmio ou hidróxido de cálcio em dorso de ratos. Estas drogas podem ser usadas como curativo intracanal para eliminar bactérias residuais do sistema de canal radicular. Metodologia: Foram utilizados 20 ratos albinos (Rattus norvegicus, var Wistar) e divididos em 4 grupos: grupo controle 1 (CG1) representado por tecido normal íntegro; grupo controle 2 (CG2) com ferida e sem medicação; nos grupos 3 e 4, Iodofórmio (IG) e hidróxido de cálcio (CHG) foram, respectivamente, inseridos nas feridas. Após três, cinco e onze dias, cortes microscópicos das áreas implantadas foram observados macroscópica e microscopicamente quanto a seus aspectos qualitativos e quantitativos. Resultados: Na análise macroscópica, o CHG mostrou uma grande área de necrose e edema, o que diminuiu progressivamente, no GI, a presença de iodofórmio rodeada por tecido normal foi observado. A análise qualitativa e quantitativa histológica mostrou que IG promoveu um prazo mais curto na resposta inflamatória do que o CHG. Conclusão: A reação inflamatória de iodofórmio teve um período de pico de cinco dias após a inserção de drogas. Em comparação, o hidróxido de cálcio mostrou uma grande área de necrose que só poderia ser parcialmente eliminada após onze dias.EDIPUCRS - Editora Universitária da PUCRS2010-02-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Articleapplication/pdfhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/5862Revista Odonto Ciência; Vol. 25 No. 1 (2010); 59 - 64Revista Odonto Ciência; v. 25 n. 1 (2010); 59 - 641980-65230102-9460reponame:Revista odonto ciência (Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/5862/4863Pallotta, Raul CappMachado, Manoel Eduardo de LimaReis, Norair Salviano dosMartins, Guilherme Henrique RosaNabeshima, Cleber Keitiinfo:eu-repo/semantics/openAccess2013-11-11T12:48:37Zoai:ojs.revistaseletronicas.pucrs.br:article/5862Revistahttps://revistaseletronicas.pucrs.br/ojs/index.php/foPRIhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/oai||odontociencia@pucrs.br1980-65230102-9460opendoar:2013-11-11T12:48:37Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Tissue inflammatory response to implantation of calcium hydroxide and iodoform in the back of rats
Resposta inflamatória tecidual da implantação de hidróxido de cálcio e iodofórmio em dorso de ratos
title Tissue inflammatory response to implantation of calcium hydroxide and iodoform in the back of rats
spellingShingle Tissue inflammatory response to implantation of calcium hydroxide and iodoform in the back of rats
Pallotta, Raul Capp
Calcium hydroxide
Endodontics
inflammation
iodoform
title_short Tissue inflammatory response to implantation of calcium hydroxide and iodoform in the back of rats
title_full Tissue inflammatory response to implantation of calcium hydroxide and iodoform in the back of rats
title_fullStr Tissue inflammatory response to implantation of calcium hydroxide and iodoform in the back of rats
title_full_unstemmed Tissue inflammatory response to implantation of calcium hydroxide and iodoform in the back of rats
title_sort Tissue inflammatory response to implantation of calcium hydroxide and iodoform in the back of rats
author Pallotta, Raul Capp
author_facet Pallotta, Raul Capp
Machado, Manoel Eduardo de Lima
Reis, Norair Salviano dos
Martins, Guilherme Henrique Rosa
Nabeshima, Cleber Keiti
author_role author
author2 Machado, Manoel Eduardo de Lima
Reis, Norair Salviano dos
Martins, Guilherme Henrique Rosa
Nabeshima, Cleber Keiti
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Pallotta, Raul Capp
Machado, Manoel Eduardo de Lima
Reis, Norair Salviano dos
Martins, Guilherme Henrique Rosa
Nabeshima, Cleber Keiti
dc.subject.por.fl_str_mv Calcium hydroxide
Endodontics
inflammation
iodoform
topic Calcium hydroxide
Endodontics
inflammation
iodoform
description Purpose: This study evaluated the inflammatory reaction caused by the implantation of iodoform and calcium hydroxide in the back of rats. These drugs may be used as intracanal dressings to eliminate residual bacteria of the root canal system. Methods: Twenty albinic rats (Rattus norvegicus, var Wistar) were divided into four groups: control group 1 (CG1) had normal skin; control group 2 (CG2) had wounded tissue without drugs; in groups 3 and 4, iodoform (IG) and calcium hydroxide (CHG) were inserted into the wounds, respectively. After 3, 5 and 11 days, slices of the implanted areas were macroscopically and microscopically observed regarding to their qualitative and quantitative aspects. Results: In the macroscopical analysis, the CHG showed a large area of necrosis and swelling, which progressively decreased; in the IG the presence of iodoform surrounded by normal tissue was observed. The qualitative and quantitative histological analysis showed that IG promoted a shorter delay in the inflammatory response than the CHG. Conclusion: The inflammatory reaction for iodoform had a peak period five days after the drug insertion. By comparison, calcium hydroxide showed a very large area of necrosis that could only be partially eliminated after eleven days.
publishDate 2010
dc.date.none.fl_str_mv 2010-02-08
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/5862
url https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/5862
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/5862/4863
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv EDIPUCRS - Editora Universitária da PUCRS
publisher.none.fl_str_mv EDIPUCRS - Editora Universitária da PUCRS
dc.source.none.fl_str_mv Revista Odonto Ciência; Vol. 25 No. 1 (2010); 59 - 64
Revista Odonto Ciência; v. 25 n. 1 (2010); 59 - 64
1980-6523
0102-9460
reponame:Revista odonto ciência (Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Revista odonto ciência (Online)
collection Revista odonto ciência (Online)
repository.name.fl_str_mv Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv ||odontociencia@pucrs.br
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