Neonatal morbidity of late preterm compared with early term neonates

Detalhes bibliográficos
Autor(a) principal: Lourenço, Nuno
Data de Publicação: 2017
Outros Autores: Fernandes, Marco, Gomes, Clara, Resende, Cristina
Tipo de documento: Artigo
Idioma: por
Título da fonte: Scientia Medica (Porto Alegre. Online)
Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/25876
Resumo: DOI: 10.15448/1980-6108.2017.1.25876Aims: To evaluate and compare neonatal morbidity between late-preterm infants (LPTI) and early term infants (ETI).Methods: Retrospective cross-sectional study, including live births at a regional referral maternity hospital in Portugal, in the years 2014 and 2015, with gestational age between 340/7 and 386/7 weeks. LPTI (340/7-366/7 weeks) were considered as cases and ETI (370/7-386/7 weeks) were considered controls. Neonates with congenital malformations, lack of prenatal care and hospitalization for social/maternal reasons were excluded. We evaluated and compared neonatal morbidity between the two groups, using Student's t-test for comparison between means (continuous variables) and Chi-square or Fisher's test for comparison between categorical variables. Odds ratio (OR) was calculated and adjusted (aOR) to birth weight, maternal disease, type of birth and multiple pregnancy. A value of p <0,05 was considered of statistical significance.Results: A total of 1,745 neonates were evaluated: 324 cases (LPTI) and 1,421 controls (ETI). LPTI was associated with a higher frequency of maternal hypertension and gestational diabetes and higher rates of twinning and cesarean section. LPTI also had a higher risk for resuscitation (OR = 2.0 - 95%CI 1.3-3.0); hypoglycemia (aOR = 4.9 - 95%CI 2.9-8.2); hyperbilirubinemia (aOR = 4.8 - 95%CI 3.7-6.2), transient tachypnea (aOR = 6.4 - 95%CI 4.0-10.3); eating difficulties (aOR = 6.6 - 95%CI 4.8-8.9); sepsis (aOR = 4.4 - 95%CI 4.8-8.9); hospital stay ≥5 days (aOR = 8.6 - 95%CI 6.6-11.3); and lower exclusive breastfeeding rate (aOR = 0.2 - 95%CI 0.15-0.3).Conclusions: In comparison to ETI, LPTI presented a higher risk of morbidity. This study reinforces the need for appropriate clinical follow-up of LPTI in the neonatal period.
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spelling Neonatal morbidity of late preterm compared with early term neonatesMorbidade neonatal dos recém-nascidos pré-termo tardios comparados aos de termo precoceinfantnewbornprematuremorbidity.recém-nascidoprematuromorbidade.DOI: 10.15448/1980-6108.2017.1.25876Aims: To evaluate and compare neonatal morbidity between late-preterm infants (LPTI) and early term infants (ETI).Methods: Retrospective cross-sectional study, including live births at a regional referral maternity hospital in Portugal, in the years 2014 and 2015, with gestational age between 340/7 and 386/7 weeks. LPTI (340/7-366/7 weeks) were considered as cases and ETI (370/7-386/7 weeks) were considered controls. Neonates with congenital malformations, lack of prenatal care and hospitalization for social/maternal reasons were excluded. We evaluated and compared neonatal morbidity between the two groups, using Student's t-test for comparison between means (continuous variables) and Chi-square or Fisher's test for comparison between categorical variables. Odds ratio (OR) was calculated and adjusted (aOR) to birth weight, maternal disease, type of birth and multiple pregnancy. A value of p <0,05 was considered of statistical significance.Results: A total of 1,745 neonates were evaluated: 324 cases (LPTI) and 1,421 controls (ETI). LPTI was associated with a higher frequency of maternal hypertension and gestational diabetes and higher rates of twinning and cesarean section. LPTI also had a higher risk for resuscitation (OR = 2.0 - 95%CI 1.3-3.0); hypoglycemia (aOR = 4.9 - 95%CI 2.9-8.2); hyperbilirubinemia (aOR = 4.8 - 95%CI 3.7-6.2), transient tachypnea (aOR = 6.4 - 95%CI 4.0-10.3); eating difficulties (aOR = 6.6 - 95%CI 4.8-8.9); sepsis (aOR = 4.4 - 95%CI 4.8-8.9); hospital stay ≥5 days (aOR = 8.6 - 95%CI 6.6-11.3); and lower exclusive breastfeeding rate (aOR = 0.2 - 95%CI 0.15-0.3).Conclusions: In comparison to ETI, LPTI presented a higher risk of morbidity. This study reinforces the need for appropriate clinical follow-up of LPTI in the neonatal period.DOI: 10.15448/1980-6108.2017.1.25876Objetivos: Avaliar e comparar a morbidade neonatal entre recém-nascidos pré-termo tardios (RNPT-T) e recém-nascidos de termo precoce (RNT-P).Métodos: Estudo transversal retrospetivo, incluindo nascidos vivos em uma maternidade hospitalar de referência regional em Portugal, nos anos de 2014 e 2015, com idade gestacional entre 340/7 e 386/7 semanas. Os RNPT-T (340/7 - 366/7semanas) foram considerados casos e os RNT-P (370/7 - 386/7 semanas) foram considerados controles. Foram excluídos recém-nascidos com malformações congênitas, ausência de acompanhamento pré-natal e internação por motivo social ou causa materna. Foi avaliada e comparada a morbidade neonatal entre os dois grupos, utilizando o teste t de Student para comparação entre médias (variáveis contínuas) e o Qui-quadrado ou teste de Fisher para comparação entre variáveis categóricas. As odds ratio (OR) com seus respetivos intervalos de confiança (IC) 95% foram ajustadas (ORa) ao peso de nascimento, tipo de parto, patologia materna e gemelaridade. Considerou-se o valor p<0.05 como estatisticamente significativo.Resultados: Foram avaliados 1.745 recém-nascidos, sendo 324 casos (RNPT-T) e 1.421 controles (RNT-P). Os RNPT-T associaram-se a maior frequência de hipertensão materna e diabetes gestacional e maiores taxas de gemelaridade e de cesariana. Os RNPT-T tiveram também um maior risco de necessidade de reanimação (OR=2,0 IC95% 1,3-3,0); hipoglicemia (ORa=4,9 IC95% 2,9-8,2); hiperbilirrubinemia (ORa=4,8 IC95% 3,7-6,2), taquipneia transitória (ORa=6,4 IC95% 4,0-10,3); dificuldades alimentares (ORa=6,6 IC95% 4,8-8,9); sepsis (ORa=4,4 IC95% 4,8-8,9); permanência hospitalar ≥5 dias (ORa=8,6 IC95% 6,6-11,3); e menor taxa de aleitamento materno exclusivo (ORa=0,2 IC95% 0,15-0,3).Conclusões: Em comparação aos RNT-P, os RNPT-T apresentaram maior risco de morbidade. Este estudo reforça a necessidade de um seguimento clínico apropriado aos RNPT-T no período neonatal.Editora da PUCRS - ediPUCRS2017-03-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/2587610.15448/1980-6108.2017.1.25876Scientia Medica; Vol. 27 No. 1 (2017); ID25876Scientia Medica; v. 27 n. 1 (2017); ID258761980-61081806-556210.15448/1980-6108.2017.1reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/25876/15477Copyright (c) 2017 Scientia Medicainfo:eu-repo/semantics/openAccessLourenço, NunoFernandes, MarcoGomes, ClaraResende, Cristina2017-08-03T17:16:13Zoai:ojs.revistaseletronicas.pucrs.br:article/25876Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2017-08-03T17:16:13Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Neonatal morbidity of late preterm compared with early term neonates
Morbidade neonatal dos recém-nascidos pré-termo tardios comparados aos de termo precoce
title Neonatal morbidity of late preterm compared with early term neonates
spellingShingle Neonatal morbidity of late preterm compared with early term neonates
Lourenço, Nuno
infant
newborn
premature
morbidity.
recém-nascido
prematuro
morbidade.
title_short Neonatal morbidity of late preterm compared with early term neonates
title_full Neonatal morbidity of late preterm compared with early term neonates
title_fullStr Neonatal morbidity of late preterm compared with early term neonates
title_full_unstemmed Neonatal morbidity of late preterm compared with early term neonates
title_sort Neonatal morbidity of late preterm compared with early term neonates
author Lourenço, Nuno
author_facet Lourenço, Nuno
Fernandes, Marco
Gomes, Clara
Resende, Cristina
author_role author
author2 Fernandes, Marco
Gomes, Clara
Resende, Cristina
author2_role author
author
author
dc.contributor.author.fl_str_mv Lourenço, Nuno
Fernandes, Marco
Gomes, Clara
Resende, Cristina
dc.subject.por.fl_str_mv infant
newborn
premature
morbidity.
recém-nascido
prematuro
morbidade.
topic infant
newborn
premature
morbidity.
recém-nascido
prematuro
morbidade.
description DOI: 10.15448/1980-6108.2017.1.25876Aims: To evaluate and compare neonatal morbidity between late-preterm infants (LPTI) and early term infants (ETI).Methods: Retrospective cross-sectional study, including live births at a regional referral maternity hospital in Portugal, in the years 2014 and 2015, with gestational age between 340/7 and 386/7 weeks. LPTI (340/7-366/7 weeks) were considered as cases and ETI (370/7-386/7 weeks) were considered controls. Neonates with congenital malformations, lack of prenatal care and hospitalization for social/maternal reasons were excluded. We evaluated and compared neonatal morbidity between the two groups, using Student's t-test for comparison between means (continuous variables) and Chi-square or Fisher's test for comparison between categorical variables. Odds ratio (OR) was calculated and adjusted (aOR) to birth weight, maternal disease, type of birth and multiple pregnancy. A value of p <0,05 was considered of statistical significance.Results: A total of 1,745 neonates were evaluated: 324 cases (LPTI) and 1,421 controls (ETI). LPTI was associated with a higher frequency of maternal hypertension and gestational diabetes and higher rates of twinning and cesarean section. LPTI also had a higher risk for resuscitation (OR = 2.0 - 95%CI 1.3-3.0); hypoglycemia (aOR = 4.9 - 95%CI 2.9-8.2); hyperbilirubinemia (aOR = 4.8 - 95%CI 3.7-6.2), transient tachypnea (aOR = 6.4 - 95%CI 4.0-10.3); eating difficulties (aOR = 6.6 - 95%CI 4.8-8.9); sepsis (aOR = 4.4 - 95%CI 4.8-8.9); hospital stay ≥5 days (aOR = 8.6 - 95%CI 6.6-11.3); and lower exclusive breastfeeding rate (aOR = 0.2 - 95%CI 0.15-0.3).Conclusions: In comparison to ETI, LPTI presented a higher risk of morbidity. This study reinforces the need for appropriate clinical follow-up of LPTI in the neonatal period.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/25876
10.15448/1980-6108.2017.1.25876
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/25876
identifier_str_mv 10.15448/1980-6108.2017.1.25876
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/25876/15477
dc.rights.driver.fl_str_mv Copyright (c) 2017 Scientia Medica
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Scientia Medica
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 27 No. 1 (2017); ID25876
Scientia Medica; v. 27 n. 1 (2017); ID25876
1980-6108
1806-5562
10.15448/1980-6108.2017.1
reponame:Scientia Medica (Porto Alegre. Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Scientia Medica (Porto Alegre. Online)
collection Scientia Medica (Porto Alegre. Online)
repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
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