Gluten allergy: series of nine cases

Detalhes bibliográficos
Autor(a) principal: Maia, Estefânia Barrosa
Data de Publicação: 2014
Outros Autores: Lemos, Sónia Gaspar, Loureiro, Carla Chaves, Pinheiro, José António
Tipo de documento: Artigo
Idioma: por
Título da fonte: Scientia Medica (Porto Alegre. Online)
Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/16293
Resumo: AIMS: With few reported cases of IgE-mediated allergy to gluten, we report a series of nine cases, with special emphasis on diagnosis, process of sensitization, clinical manifestations and predictive factors of prognosis. METHODS: In this series all cases of IgE-mediated allergy to gluten, followed the last 15 years at the Pediatric Allergology of a tertiary hospital, were included. Age of onset, initial symptoms, routes of sensitization, comorbidities and acquisition of tolerance were analyzed. RESULTS: with gluten allergy, with ages ranging from 1 to 14 years, were included; eight were boys. The first manifestation took place between 5 and 9 months. In six patients the initial symptoms were cutaneous, two patients had gastrointestinal disorders, and one girl showed anaphylaxis as the initial manifestation. The route of sensitization was cutaneous or by food ingestion. Serum specific IgE to gluten ranged from 0,73 to 100KUA/l. All children exhibited other atopic diseases. Eight children had multiple food allergies and four developed respiratory allergy. Two patients suffered anaphylaxis after the diagnosis. Three cases resolved their gluten allergy up to eight years of age. CONCLUSIONS: Gluten allergy is rare, explaining the small number diagnosed in 15 years, in a central referral hospital. The nine cases began in the first year of life, being cutaneous manifestations the most frequent. Eczema is a common presentation and there was dermal sensitization in some cases. Multiple food allergy was also frequent in the cases described. Three of the nine children resolved allergy up to six years, having in common an initial cutaneous manifestation. In these nine cases, the value of specific IgE was not predictive of clinical outcome.
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spelling Gluten allergy: series of nine casesAlergia ao glúten: série de nove casosGLUTEN ALLERGYFOOD ALLERGYANAPHYLAXISATOPIC DERMATITIS.ALERGIA A GLUTENALERGIA ALIMENTARANAFILAXIADERMATITE ATÓPICA.AIMS: With few reported cases of IgE-mediated allergy to gluten, we report a series of nine cases, with special emphasis on diagnosis, process of sensitization, clinical manifestations and predictive factors of prognosis. METHODS: In this series all cases of IgE-mediated allergy to gluten, followed the last 15 years at the Pediatric Allergology of a tertiary hospital, were included. Age of onset, initial symptoms, routes of sensitization, comorbidities and acquisition of tolerance were analyzed. RESULTS: with gluten allergy, with ages ranging from 1 to 14 years, were included; eight were boys. The first manifestation took place between 5 and 9 months. In six patients the initial symptoms were cutaneous, two patients had gastrointestinal disorders, and one girl showed anaphylaxis as the initial manifestation. The route of sensitization was cutaneous or by food ingestion. Serum specific IgE to gluten ranged from 0,73 to 100KUA/l. All children exhibited other atopic diseases. Eight children had multiple food allergies and four developed respiratory allergy. Two patients suffered anaphylaxis after the diagnosis. Three cases resolved their gluten allergy up to eight years of age. CONCLUSIONS: Gluten allergy is rare, explaining the small number diagnosed in 15 years, in a central referral hospital. The nine cases began in the first year of life, being cutaneous manifestations the most frequent. Eczema is a common presentation and there was dermal sensitization in some cases. Multiple food allergy was also frequent in the cases described. Three of the nine children resolved allergy up to six years, having in common an initial cutaneous manifestation. In these nine cases, the value of specific IgE was not predictive of clinical outcome.OBJETIVOS: Havendo poucos casos descritos de alergia ao glúten mediada por IgE, divulgamos uma série de nove casos, com especial relevo sobre o diagnóstico, vias de sensibilização, manifestações clínicas e factores preditivos de prognóstico. MÉTODOS: Nesta série foram incluídos todos os casos de alergia ao glúten mediada por IgE, seguidos nos últimos 15 anos no ambulatório de Alergologia Pediátrica de um hospital terciário. Foram analisadas idade de início, manifestações iniciais, vias de sensibilização, comorbidades e aquisição de tolerância. RESULTADOS: Foram incluídas nove crianças com alergia ao glúten, com idades entre 1 e 14 anos, sendo oito meninos. A primeira manifestação ocorreu entre os 5 e 9 meses. Em seis pacientes as primeiras manifestações foram cutâneas, dois apresentaram distúrbios gastrointestinais e uma menina apresentou anafilaxia como manifestação inicial. A via de sensibilização foi cutânea ou por ingestão. O valor de IgE específica para o glúten variou entre 0,73-100 KUA/l. Todas as crianças tinham outra doença atópica. Oito apresentavam alergia alimentar múltipla. Quatro desenvolveram alergia respiratória. Em dois casos ocorreu anafilaxia após o diagnóstico. Três resolveram a alergia ao glúten até os seis anos. CONCLUSÕES: A alergia ao glúten é rara, explicando o pequeno número diagnosticado em 15 anos, em um hospital central de referência. Os nove casos tiveram início no primeiro ano de vida, sendo as manifestações cutâneas as mais frequentes. O eczema foi uma apresentação frequente e a sensibilização foi por via cutânea em alguns casos. A alergia alimentar múltipla também foi frequente nos casos descritos. Três das nove crianças resolveram a alergia até os seis anos, tendo em comum uma manifestação inicial cutânea. Nestes nove casos, o valor de IgE específica não foi preditivo da evolução clínica.Editora da PUCRS - ediPUCRS2014-07-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArtigo OriginalArtigo originalapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1629310.15448/1980-6108.2014.3.16293Scientia Medica; Vol. 24 No. 3 (2014); 259-263Scientia Medica; v. 24 n. 3 (2014); 259-2631980-61081806-556210.15448/1980-6108.2014.3reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/16293/11621Maia, Estefânia BarrosaLemos, Sónia GasparLoureiro, Carla ChavesPinheiro, José Antónioinfo:eu-repo/semantics/openAccess2017-08-28T14:51:17Zoai:ojs.revistaseletronicas.pucrs.br:article/16293Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2017-08-28T14:51:17Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Gluten allergy: series of nine cases
Alergia ao glúten: série de nove casos
title Gluten allergy: series of nine cases
spellingShingle Gluten allergy: series of nine cases
Maia, Estefânia Barrosa
GLUTEN ALLERGY
FOOD ALLERGY
ANAPHYLAXIS
ATOPIC DERMATITIS.
ALERGIA A GLUTEN
ALERGIA ALIMENTAR
ANAFILAXIA
DERMATITE ATÓPICA.
title_short Gluten allergy: series of nine cases
title_full Gluten allergy: series of nine cases
title_fullStr Gluten allergy: series of nine cases
title_full_unstemmed Gluten allergy: series of nine cases
title_sort Gluten allergy: series of nine cases
author Maia, Estefânia Barrosa
author_facet Maia, Estefânia Barrosa
Lemos, Sónia Gaspar
Loureiro, Carla Chaves
Pinheiro, José António
author_role author
author2 Lemos, Sónia Gaspar
Loureiro, Carla Chaves
Pinheiro, José António
author2_role author
author
author
dc.contributor.author.fl_str_mv Maia, Estefânia Barrosa
Lemos, Sónia Gaspar
Loureiro, Carla Chaves
Pinheiro, José António
dc.subject.por.fl_str_mv GLUTEN ALLERGY
FOOD ALLERGY
ANAPHYLAXIS
ATOPIC DERMATITIS.
ALERGIA A GLUTEN
ALERGIA ALIMENTAR
ANAFILAXIA
DERMATITE ATÓPICA.
topic GLUTEN ALLERGY
FOOD ALLERGY
ANAPHYLAXIS
ATOPIC DERMATITIS.
ALERGIA A GLUTEN
ALERGIA ALIMENTAR
ANAFILAXIA
DERMATITE ATÓPICA.
description AIMS: With few reported cases of IgE-mediated allergy to gluten, we report a series of nine cases, with special emphasis on diagnosis, process of sensitization, clinical manifestations and predictive factors of prognosis. METHODS: In this series all cases of IgE-mediated allergy to gluten, followed the last 15 years at the Pediatric Allergology of a tertiary hospital, were included. Age of onset, initial symptoms, routes of sensitization, comorbidities and acquisition of tolerance were analyzed. RESULTS: with gluten allergy, with ages ranging from 1 to 14 years, were included; eight were boys. The first manifestation took place between 5 and 9 months. In six patients the initial symptoms were cutaneous, two patients had gastrointestinal disorders, and one girl showed anaphylaxis as the initial manifestation. The route of sensitization was cutaneous or by food ingestion. Serum specific IgE to gluten ranged from 0,73 to 100KUA/l. All children exhibited other atopic diseases. Eight children had multiple food allergies and four developed respiratory allergy. Two patients suffered anaphylaxis after the diagnosis. Three cases resolved their gluten allergy up to eight years of age. CONCLUSIONS: Gluten allergy is rare, explaining the small number diagnosed in 15 years, in a central referral hospital. The nine cases began in the first year of life, being cutaneous manifestations the most frequent. Eczema is a common presentation and there was dermal sensitization in some cases. Multiple food allergy was also frequent in the cases described. Three of the nine children resolved allergy up to six years, having in common an initial cutaneous manifestation. In these nine cases, the value of specific IgE was not predictive of clinical outcome.
publishDate 2014
dc.date.none.fl_str_mv 2014-07-05
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Artigo Original
Artigo original
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/16293
10.15448/1980-6108.2014.3.16293
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/16293
identifier_str_mv 10.15448/1980-6108.2014.3.16293
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/16293/11621
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 24 No. 3 (2014); 259-263
Scientia Medica; v. 24 n. 3 (2014); 259-263
1980-6108
1806-5562
10.15448/1980-6108.2014.3
reponame:Scientia Medica (Porto Alegre. Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Scientia Medica (Porto Alegre. Online)
collection Scientia Medica (Porto Alegre. Online)
repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
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