Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence Abstract in English

Detalhes bibliográficos
Autor(a) principal: Marini, Gabriela
Data de Publicação: 2011
Outros Autores: Piculo, Fernanda, Pascon Barbosa, Angélica Mércia, Damasceno, Débora Cristina, Michelin Matheus, Selma Maria, Vieira Cunha Rudge, Marilza
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Scientia Medica (Porto Alegre. Online)
Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/9230
Resumo: AIMS: To discuss the importance of studying animal models to test hypotheses about the mechanisms of urinary continence and pathophysiology of diabetes and urinary incontinence. SOURCE OF DATA: A literature review was conducted in PubMed and SciELO. The key words used were diabetes, urinary incontinence, urethra, human and rats. SUMMARY OF FINDINGS: There is a strong relation between the genesis of urinary incontinence and diabetes mellitus. Due to the similarity of normal distribution of skeletal muscle and urethra anatomy between humans and rats, these animal models have been used in current research about these disorders. CONCLUSIONS: The use of rats as an animal model is suitable for experimental studies that test hypotheses about the mechanisms of continence and pathophysiology of the binomial diabetes mellitus and urinary incontinence, thus enabling solutions of great value in clinical practice.
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spelling Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence Abstract in EnglishImportância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária femininaDIABETES MELLITUS/physiopathologyURINARY INCONTINENCE/physiopathologyURETHRA/anatomy & histologyMUSCLESTRIATED/anatomy & histologyMODELSANIMALFEMALERATS.DIABETES MELLITUS/fisiopatologiaINCONTINÊNCIA URINÁRIA/fisiopatologiaURETRA/anatomia & histologiaMÚSCULO ESTRIADO/ anatomia & histologiaMODELOS ANIMAISFEMININORATOS.AIMS: To discuss the importance of studying animal models to test hypotheses about the mechanisms of urinary continence and pathophysiology of diabetes and urinary incontinence. SOURCE OF DATA: A literature review was conducted in PubMed and SciELO. The key words used were diabetes, urinary incontinence, urethra, human and rats. SUMMARY OF FINDINGS: There is a strong relation between the genesis of urinary incontinence and diabetes mellitus. Due to the similarity of normal distribution of skeletal muscle and urethra anatomy between humans and rats, these animal models have been used in current research about these disorders. CONCLUSIONS: The use of rats as an animal model is suitable for experimental studies that test hypotheses about the mechanisms of continence and pathophysiology of the binomial diabetes mellitus and urinary incontinence, thus enabling solutions of great value in clinical practice.OBJETIVOS: discutir a importância do estudo de modelos animais para testar hipóteses sobre os mecanismos de continência urinária e fisiopatologia do binômio diabetes incontinência urinária. FONTE DE DADOS: foi realizada revisão de literatura no PubMed e SciELO. Os descritores utilizados foram diabetes, urinary incontinence, urethra, human e rats. SÍNTESE DOS DADOS: existe forte correlação entre a gênese da incontinência urinária e o diabetes mellitus. Devido à similaridade entre a distribuição normal da musculatura estriada e da neuroanatomia da uretra em mulheres e em ratas, estes modelos animais vêm sendo cada vez mais utilizados nas pesquisas sobre esses distúrbios. CONCLUSÕES: o uso de ratas como modelo animal é apropriado para estudos experimentais que testam hipóteses sobre os mecanismos de continência e a fisiopatologia do binômio diabetes mellitus e incontinência urinária, possibilitando assim, soluções de grande valia na prática clínica.Editora da PUCRS - ediPUCRS2011-12-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/9230Scientia Medica; Vol. 21 No. 4 (2011); 191-195Scientia Medica; v. 21 n. 4 (2011); 191-1951980-61081806-5562reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporenghttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/9230/7246https://revistaseletronicas.pucrs.br/scientiamedica/article/view/9230/7247Marini, GabrielaPiculo, FernandaPascon Barbosa, Angélica MérciaDamasceno, Débora CristinaMichelin Matheus, Selma MariaVieira Cunha Rudge, Marilzainfo:eu-repo/semantics/openAccess2013-07-16T11:53:52Zoai:ojs.revistaseletronicas.pucrs.br:article/9230Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2013-07-16T11:53:52Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence Abstract in English
Importância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária feminina
title Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence Abstract in English
spellingShingle Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence Abstract in English
Marini, Gabriela
DIABETES MELLITUS/physiopathology
URINARY INCONTINENCE/physiopathology
URETHRA/anatomy & histology
MUSCLE
STRIATED/anatomy & histology
MODELS
ANIMAL
FEMALE
RATS.
DIABETES MELLITUS/fisiopatologia
INCONTINÊNCIA URINÁRIA/fisiopatologia
URETRA/anatomia & histologia
MÚSCULO ESTRIADO/ anatomia & histologia
MODELOS ANIMAIS
FEMININO
RATOS.
title_short Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence Abstract in English
title_full Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence Abstract in English
title_fullStr Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence Abstract in English
title_full_unstemmed Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence Abstract in English
title_sort Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence Abstract in English
author Marini, Gabriela
author_facet Marini, Gabriela
Piculo, Fernanda
Pascon Barbosa, Angélica Mércia
Damasceno, Débora Cristina
Michelin Matheus, Selma Maria
Vieira Cunha Rudge, Marilza
author_role author
author2 Piculo, Fernanda
Pascon Barbosa, Angélica Mércia
Damasceno, Débora Cristina
Michelin Matheus, Selma Maria
Vieira Cunha Rudge, Marilza
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Marini, Gabriela
Piculo, Fernanda
Pascon Barbosa, Angélica Mércia
Damasceno, Débora Cristina
Michelin Matheus, Selma Maria
Vieira Cunha Rudge, Marilza
dc.subject.por.fl_str_mv DIABETES MELLITUS/physiopathology
URINARY INCONTINENCE/physiopathology
URETHRA/anatomy & histology
MUSCLE
STRIATED/anatomy & histology
MODELS
ANIMAL
FEMALE
RATS.
DIABETES MELLITUS/fisiopatologia
INCONTINÊNCIA URINÁRIA/fisiopatologia
URETRA/anatomia & histologia
MÚSCULO ESTRIADO/ anatomia & histologia
MODELOS ANIMAIS
FEMININO
RATOS.
topic DIABETES MELLITUS/physiopathology
URINARY INCONTINENCE/physiopathology
URETHRA/anatomy & histology
MUSCLE
STRIATED/anatomy & histology
MODELS
ANIMAL
FEMALE
RATS.
DIABETES MELLITUS/fisiopatologia
INCONTINÊNCIA URINÁRIA/fisiopatologia
URETRA/anatomia & histologia
MÚSCULO ESTRIADO/ anatomia & histologia
MODELOS ANIMAIS
FEMININO
RATOS.
description AIMS: To discuss the importance of studying animal models to test hypotheses about the mechanisms of urinary continence and pathophysiology of diabetes and urinary incontinence. SOURCE OF DATA: A literature review was conducted in PubMed and SciELO. The key words used were diabetes, urinary incontinence, urethra, human and rats. SUMMARY OF FINDINGS: There is a strong relation between the genesis of urinary incontinence and diabetes mellitus. Due to the similarity of normal distribution of skeletal muscle and urethra anatomy between humans and rats, these animal models have been used in current research about these disorders. CONCLUSIONS: The use of rats as an animal model is suitable for experimental studies that test hypotheses about the mechanisms of continence and pathophysiology of the binomial diabetes mellitus and urinary incontinence, thus enabling solutions of great value in clinical practice.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-05
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/9230
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/9230
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/9230/7246
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/9230/7247
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 21 No. 4 (2011); 191-195
Scientia Medica; v. 21 n. 4 (2011); 191-195
1980-6108
1806-5562
reponame:Scientia Medica (Porto Alegre. Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Scientia Medica (Porto Alegre. Online)
collection Scientia Medica (Porto Alegre. Online)
repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
_version_ 1809101749564211200

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