Importância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária feminina

Detalhes bibliográficos
Autor(a) principal: Marini, Gabriela [UNESP]
Data de Publicação: 2011
Outros Autores: Piculo, Fernanda [UNESP], Barbosa, Angélica Mércia Pascon [UNESP], Damasceno, Débora Cristina [UNESP], Matheus, Selma Maria Michelin [UNESP], Rudge, Marilza Vieira Cunha [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://revistaseletronicas.pucrs.br/ojs/index.php/scientiamedica/article/view/9230
http://hdl.handle.net/11449/73082
Resumo: Aims: To discuss the importance of studying animal models to test hypotheses about the mechanisms of urinary continence and pathophysiology of diabetes and urinary incontinence. Source of Data: A literature review was conducted in PubMed and SciELO. The key words used were diabetes, urinary incontinence, urethra, human and rats. Summary of Findings: There is a strong relation between the genesis of urinary incontinence and diabetes mellitus. Due to the similarity of normal distribution of skeletal muscle and urethra anatomy between humans and rats, these animal models have been used in current research about these disorders. Conclusions: The use of rats as an animal model is suitable for experimental studies that test hypotheses about the mechanisms of continence and pathophysiology of the binomial diabetes mellitus and urinary incontinence, thus enabling solutions of great value in clinical practice.
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spelling Importância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária femininaImportance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinenceAnimalDiabetes mellitus/physiopathologyFemaleModelsMuscleRatsStriated/anatomy histologyUrethra/anatomy histologyUrinary incontinence/physiopathologydiabetes mellitusdisease associationdisease modelexperimental ratexperimental studyfemalehumanmorphologynonhumanpathophysiologyreviewskeletal musclesystematic reviewurethraurine incontinenceAims: To discuss the importance of studying animal models to test hypotheses about the mechanisms of urinary continence and pathophysiology of diabetes and urinary incontinence. Source of Data: A literature review was conducted in PubMed and SciELO. The key words used were diabetes, urinary incontinence, urethra, human and rats. Summary of Findings: There is a strong relation between the genesis of urinary incontinence and diabetes mellitus. Due to the similarity of normal distribution of skeletal muscle and urethra anatomy between humans and rats, these animal models have been used in current research about these disorders. Conclusions: The use of rats as an animal model is suitable for experimental studies that test hypotheses about the mechanisms of continence and pathophysiology of the binomial diabetes mellitus and urinary incontinence, thus enabling solutions of great value in clinical practice.Laboratório de Pesquisa Experimental de Ginecologia e Obstetrícia Departamento de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São PauloDepartamento de Anatomia Instituto de Biociências de Botucatu Universidade Estadual Paulista, São PauloLaboratório de Pesquisa Experimental de Ginecologia e Obstetrícia Departamento de Ginecologia e Obstetrícia Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, São PauloDepartamento de Anatomia Instituto de Biociências de Botucatu Universidade Estadual Paulista, São PauloUniversidade Estadual Paulista (Unesp)Marini, Gabriela [UNESP]Piculo, Fernanda [UNESP]Barbosa, Angélica Mércia Pascon [UNESP]Damasceno, Débora Cristina [UNESP]Matheus, Selma Maria Michelin [UNESP]Rudge, Marilza Vieira Cunha [UNESP]2014-05-27T11:26:20Z2014-05-27T11:26:20Z2011-12-23info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article191-195application/pdfhttp://revistaseletronicas.pucrs.br/ojs/index.php/scientiamedica/article/view/9230Scientia Medica, v. 21, n. 4, p. 191-195, 2011.1806-55621980-6108http://hdl.handle.net/11449/730822-s2.0-837552076712-s2.0-83755207671.pdf67586803888350780000-0002-9227-832XScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporScientia Medica0,1230,123info:eu-repo/semantics/openAccess2024-08-16T14:06:24Zoai:repositorio.unesp.br:11449/73082Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:06:24Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Importância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária feminina
Importance of animal model to test hypotheses about the pathophysiology of the binomial diabetes and female urinary incontinence
title Importância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária feminina
spellingShingle Importância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária feminina
Marini, Gabriela [UNESP]
Animal
Diabetes mellitus/physiopathology
Female
Models
Muscle
Rats
Striated/anatomy histology
Urethra/anatomy histology
Urinary incontinence/physiopathology
diabetes mellitus
disease association
disease model
experimental rat
experimental study
female
human
morphology
nonhuman
pathophysiology
review
skeletal muscle
systematic review
urethra
urine incontinence
title_short Importância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária feminina
title_full Importância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária feminina
title_fullStr Importância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária feminina
title_full_unstemmed Importância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária feminina
title_sort Importância do modelo animal para testar hipóteses sobre a fisiopatologia do binômio diabetes e incontinência urinária feminina
author Marini, Gabriela [UNESP]
author_facet Marini, Gabriela [UNESP]
Piculo, Fernanda [UNESP]
Barbosa, Angélica Mércia Pascon [UNESP]
Damasceno, Débora Cristina [UNESP]
Matheus, Selma Maria Michelin [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
author_role author
author2 Piculo, Fernanda [UNESP]
Barbosa, Angélica Mércia Pascon [UNESP]
Damasceno, Débora Cristina [UNESP]
Matheus, Selma Maria Michelin [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Marini, Gabriela [UNESP]
Piculo, Fernanda [UNESP]
Barbosa, Angélica Mércia Pascon [UNESP]
Damasceno, Débora Cristina [UNESP]
Matheus, Selma Maria Michelin [UNESP]
Rudge, Marilza Vieira Cunha [UNESP]
dc.subject.por.fl_str_mv Animal
Diabetes mellitus/physiopathology
Female
Models
Muscle
Rats
Striated/anatomy histology
Urethra/anatomy histology
Urinary incontinence/physiopathology
diabetes mellitus
disease association
disease model
experimental rat
experimental study
female
human
morphology
nonhuman
pathophysiology
review
skeletal muscle
systematic review
urethra
urine incontinence
topic Animal
Diabetes mellitus/physiopathology
Female
Models
Muscle
Rats
Striated/anatomy histology
Urethra/anatomy histology
Urinary incontinence/physiopathology
diabetes mellitus
disease association
disease model
experimental rat
experimental study
female
human
morphology
nonhuman
pathophysiology
review
skeletal muscle
systematic review
urethra
urine incontinence
description Aims: To discuss the importance of studying animal models to test hypotheses about the mechanisms of urinary continence and pathophysiology of diabetes and urinary incontinence. Source of Data: A literature review was conducted in PubMed and SciELO. The key words used were diabetes, urinary incontinence, urethra, human and rats. Summary of Findings: There is a strong relation between the genesis of urinary incontinence and diabetes mellitus. Due to the similarity of normal distribution of skeletal muscle and urethra anatomy between humans and rats, these animal models have been used in current research about these disorders. Conclusions: The use of rats as an animal model is suitable for experimental studies that test hypotheses about the mechanisms of continence and pathophysiology of the binomial diabetes mellitus and urinary incontinence, thus enabling solutions of great value in clinical practice.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-23
2014-05-27T11:26:20Z
2014-05-27T11:26:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://revistaseletronicas.pucrs.br/ojs/index.php/scientiamedica/article/view/9230
Scientia Medica, v. 21, n. 4, p. 191-195, 2011.
1806-5562
1980-6108
http://hdl.handle.net/11449/73082
2-s2.0-83755207671
2-s2.0-83755207671.pdf
6758680388835078
0000-0002-9227-832X
url http://revistaseletronicas.pucrs.br/ojs/index.php/scientiamedica/article/view/9230
http://hdl.handle.net/11449/73082
identifier_str_mv Scientia Medica, v. 21, n. 4, p. 191-195, 2011.
1806-5562
1980-6108
2-s2.0-83755207671
2-s2.0-83755207671.pdf
6758680388835078
0000-0002-9227-832X
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Scientia Medica
0,123
0,123
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 191-195
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128104682487808

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