Prognostic factors and long-term survival in oral squamous cell carcinoma: A cross-sectional study

Detalhes bibliográficos
Autor(a) principal: Rocha, Carlos Eduardo Moura Carvalho
Data de Publicação: 2021
Outros Autores: Santos, Júlio César Saraiva, Costa, Rafael Everton Assunção Ribeiro da, Pinto, Eduardo Salmito Soares, Almeida, Ana Luisa Rios Barbosa de, Lima, Cacilda Castelo Branco, Nogueira, Luciana Tolstenko, Pinto, Lucielma Salmito Soares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Scientia Medica (Porto Alegre. Online)
Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/41124
Resumo: Objective: this study aimed to evaluate long-term survival and prognostic factors in patients with oral squamous cell carcinoma (OSCC) in an economically poor region of Brazil.Methods: the data were obtained from analysis of medical and mortality records of 210 patients with OSCC treated at an oncology hospital providing services to the Brazilian Unified National Health System in a State of northeastern Brazil between January 2006 and December 2008. Sociodemographic and clinical information, treatment performed, recurrence and evolution were collected. Survival curves were estimated by the Kaplan-Meier method and the log rank and Cox regression tests were used to compare the curves.Results: the median survival in the study period was 47.4 months (95% CI = 38.2 - 56.7). The overall survival rates at 5 and 10 years were 29% and 19.8%, respectivelly. Individuals over 60 years of age (HR = 1.70; 95% CI = 1.06 - 2.73), presence of regional metastasis (HR = 2.51; 95% CI = 1.55 - 4.08), presence of recurrence (HR = 3.18; 95% CI = 1.88 - 5.39) and no surgical treatment (HR = 2.10; 95% CI = 1.31 - 3.35) had a worse prognosis.Conclusions: advanced age, presence of regional metastasis, tumor recurrence and non-surgical treatment predict poorer survival in patients diagnosed with OSCC.
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spelling Prognostic factors and long-term survival in oral squamous cell carcinoma: A cross-sectional studyFatores prognósticos e sobrevida a longo prazo em carcinoma espinocelular bucal: Um estudo transversalprognosissurvival analysismedical recordsmouth neoplasmscarcinoma squamous cellprognósticoanálise de sobrevidaregistros médicosneoplasias bucaiscarcinoma de células escamosasObjective: this study aimed to evaluate long-term survival and prognostic factors in patients with oral squamous cell carcinoma (OSCC) in an economically poor region of Brazil.Methods: the data were obtained from analysis of medical and mortality records of 210 patients with OSCC treated at an oncology hospital providing services to the Brazilian Unified National Health System in a State of northeastern Brazil between January 2006 and December 2008. Sociodemographic and clinical information, treatment performed, recurrence and evolution were collected. Survival curves were estimated by the Kaplan-Meier method and the log rank and Cox regression tests were used to compare the curves.Results: the median survival in the study period was 47.4 months (95% CI = 38.2 - 56.7). The overall survival rates at 5 and 10 years were 29% and 19.8%, respectivelly. Individuals over 60 years of age (HR = 1.70; 95% CI = 1.06 - 2.73), presence of regional metastasis (HR = 2.51; 95% CI = 1.55 - 4.08), presence of recurrence (HR = 3.18; 95% CI = 1.88 - 5.39) and no surgical treatment (HR = 2.10; 95% CI = 1.31 - 3.35) had a worse prognosis.Conclusions: advanced age, presence of regional metastasis, tumor recurrence and non-surgical treatment predict poorer survival in patients diagnosed with OSCC.Objetivo: este estudo objetivou avaliar a sobrevida a longo prazo e fatores prognósticos de pacientes com carcinoma espinocelular bucal em uma região pouco desenvolvida economicamente do Brasil.Métodos: os dados foram obtidos a partir da análise de registros médicos de 210 pacientes com carcinoma espinocelular bucal tratados em um hospital especializado em oncologia que presta serviços ao Sistema Único de Saúde em um estado do Nordeste brasileiro entre janeiro de 2006 e dezembro de 2008. Informações clínicas, sociodemográficas e referentes aos tratamentos realizados, recidivas e evoluções foram coletadas. As curvas de sobrevida foram estimadas pelo método de Kaplan-Meier, sendo utilizado o teste de Log-rank para comparar as curvas.Resultados: a sobrevida média no estudo foi de 47.4 meses (95% IC = 38.2 - 56.7). As taxas de sobrevida global em 5 e 10 anos foram de 29% e 19.8%, respectivamente. Indivíduos com idade superior a 60 anos (RR = 1.70; 95% IC = 1.06 - 2.73), que apresentaram metástases regionais (RR = 2.51; 95% IC = 1.55 - 4.08), recidivas tumorais (RR = 3.18; 95% IC = 1.88 - 5.39) e que foram tratados apenas não cirurgicamente (RR = 2.10; 95% IC = 1.31 - 3.35) tiveram pior prognóstico.Conclusões: idade avançada, presença de metástases regionais, recidivas tumorais e tratamento apenas não cirúrgico foram preditores de pior sobrevida em pacientes diagnosticados com carcinoma espinocelular bucal.Editora da PUCRS - ediPUCRS2021-10-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/4112410.15448/1980-6108.2021.1.41124Scientia Medica; Vol. 31 No. 1 (2021): Single Volume; e41124Scientia Medica; v. 31 n. 1 (2021): Volume Único; e411241980-61081806-556210.15448/1980-6108.2021.1reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/41124/27151Copyright (c) 2021 Scientia Medicahttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRocha, Carlos Eduardo Moura CarvalhoSantos, Júlio César SaraivaCosta, Rafael Everton Assunção Ribeiro daPinto, Eduardo Salmito SoaresAlmeida, Ana Luisa Rios Barbosa deLima, Cacilda Castelo BrancoNogueira, Luciana TolstenkoPinto, Lucielma Salmito Soares2022-01-25T17:01:59Zoai:ojs.revistaseletronicas.pucrs.br:article/41124Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2022-01-25T17:01:59Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Prognostic factors and long-term survival in oral squamous cell carcinoma: A cross-sectional study
Fatores prognósticos e sobrevida a longo prazo em carcinoma espinocelular bucal: Um estudo transversal
title Prognostic factors and long-term survival in oral squamous cell carcinoma: A cross-sectional study
spellingShingle Prognostic factors and long-term survival in oral squamous cell carcinoma: A cross-sectional study
Rocha, Carlos Eduardo Moura Carvalho
prognosis
survival analysis
medical records
mouth neoplasms
carcinoma squamous cell
prognóstico
análise de sobrevida
registros médicos
neoplasias bucais
carcinoma de células escamosas
title_short Prognostic factors and long-term survival in oral squamous cell carcinoma: A cross-sectional study
title_full Prognostic factors and long-term survival in oral squamous cell carcinoma: A cross-sectional study
title_fullStr Prognostic factors and long-term survival in oral squamous cell carcinoma: A cross-sectional study
title_full_unstemmed Prognostic factors and long-term survival in oral squamous cell carcinoma: A cross-sectional study
title_sort Prognostic factors and long-term survival in oral squamous cell carcinoma: A cross-sectional study
author Rocha, Carlos Eduardo Moura Carvalho
author_facet Rocha, Carlos Eduardo Moura Carvalho
Santos, Júlio César Saraiva
Costa, Rafael Everton Assunção Ribeiro da
Pinto, Eduardo Salmito Soares
Almeida, Ana Luisa Rios Barbosa de
Lima, Cacilda Castelo Branco
Nogueira, Luciana Tolstenko
Pinto, Lucielma Salmito Soares
author_role author
author2 Santos, Júlio César Saraiva
Costa, Rafael Everton Assunção Ribeiro da
Pinto, Eduardo Salmito Soares
Almeida, Ana Luisa Rios Barbosa de
Lima, Cacilda Castelo Branco
Nogueira, Luciana Tolstenko
Pinto, Lucielma Salmito Soares
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rocha, Carlos Eduardo Moura Carvalho
Santos, Júlio César Saraiva
Costa, Rafael Everton Assunção Ribeiro da
Pinto, Eduardo Salmito Soares
Almeida, Ana Luisa Rios Barbosa de
Lima, Cacilda Castelo Branco
Nogueira, Luciana Tolstenko
Pinto, Lucielma Salmito Soares
dc.subject.por.fl_str_mv prognosis
survival analysis
medical records
mouth neoplasms
carcinoma squamous cell
prognóstico
análise de sobrevida
registros médicos
neoplasias bucais
carcinoma de células escamosas
topic prognosis
survival analysis
medical records
mouth neoplasms
carcinoma squamous cell
prognóstico
análise de sobrevida
registros médicos
neoplasias bucais
carcinoma de células escamosas
description Objective: this study aimed to evaluate long-term survival and prognostic factors in patients with oral squamous cell carcinoma (OSCC) in an economically poor region of Brazil.Methods: the data were obtained from analysis of medical and mortality records of 210 patients with OSCC treated at an oncology hospital providing services to the Brazilian Unified National Health System in a State of northeastern Brazil between January 2006 and December 2008. Sociodemographic and clinical information, treatment performed, recurrence and evolution were collected. Survival curves were estimated by the Kaplan-Meier method and the log rank and Cox regression tests were used to compare the curves.Results: the median survival in the study period was 47.4 months (95% CI = 38.2 - 56.7). The overall survival rates at 5 and 10 years were 29% and 19.8%, respectivelly. Individuals over 60 years of age (HR = 1.70; 95% CI = 1.06 - 2.73), presence of regional metastasis (HR = 2.51; 95% CI = 1.55 - 4.08), presence of recurrence (HR = 3.18; 95% CI = 1.88 - 5.39) and no surgical treatment (HR = 2.10; 95% CI = 1.31 - 3.35) had a worse prognosis.Conclusions: advanced age, presence of regional metastasis, tumor recurrence and non-surgical treatment predict poorer survival in patients diagnosed with OSCC.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-29
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/41124
10.15448/1980-6108.2021.1.41124
url https://revistaseletronicas.pucrs.br/scientiamedica/article/view/41124
identifier_str_mv 10.15448/1980-6108.2021.1.41124
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/scientiamedica/article/view/41124/27151
dc.rights.driver.fl_str_mv Copyright (c) 2021 Scientia Medica
http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2021 Scientia Medica
http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
publisher.none.fl_str_mv Editora da PUCRS - ediPUCRS
dc.source.none.fl_str_mv Scientia Medica; Vol. 31 No. 1 (2021): Single Volume; e41124
Scientia Medica; v. 31 n. 1 (2021): Volume Único; e41124
1980-6108
1806-5562
10.15448/1980-6108.2021.1
reponame:Scientia Medica (Porto Alegre. Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Scientia Medica (Porto Alegre. Online)
collection Scientia Medica (Porto Alegre. Online)
repository.name.fl_str_mv Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv scientiamedica@pucrs.br || editora.periodicos@pucrs.br
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