Effects of Vitamin D in the Prevention of Acute Viral Bronchiolitis: Systematic Review

• Autor(a) principal: Barba Rueda, Angélica Maria
• Data de Publicação: 2015
• Outros Autores: Sarria-Icaza, Edgar Enrique, Comerlato Scotta, Marcelo, Araújo Pinto, Leonardo, de Moura, Ângela, Becker, Rafaela, Dorigatti Soldatelli, Matheus, Epifanio, Matias, Mundstock, Eduardo, Mattiello, Rita
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Scientia Medica (Porto Alegre. Online)
• Texto Completo: https://revistaseletronicas.pucrs.br/scientiamedica/article/view/20313
• topic: Vitamin D; Bronchiolitis.; Saúde da criança

Aims: Published evidence suggests that Vitamin D supplementation may have a protective effect on infectious disease of the lower respiratory tract. The objective of this review was to critically appraise the effects of vitamin D intake in the prevention of acute viral bronchiolitis in children.Methods: We searched the databases MEDLINE, EMBASE, Web of Science, LILACS, and Cochrane Central Register of Controlled Trials, until December 2014. Keywords: "Vitamin D" OR cholecalciferol OR ergocalciferol AND "bronchiolitis, viral" OR bronchiolitides, viral OR "bronchiolitides viral". Eligibility Criteria: We included studies evaluating the effect of vitamin D intake in the prevention of acute viral bronchiolitis in young children. Studies with less than two weeks of intervention and review articles were excluded.Results: The search identified 241 articles; twenty were selected for full reading but only two were included in the systematic review, comprising 296 children. No study measured serum vitamin D. One of them was a clinical trial, where the number of episodes of acute viral bronchiolitis was significantly lower in children supplemented with vitamin D (Group I: mean: 0.6 ± 0.7 Group II: mean: 1.4 ± 0.9; p = 0.001). The other, a case-control study, did not find a significant relationship between the occurrence of  acute viral bronchiolitis cases and the intake of vitamin D (OR 1.7 95% CI 0.7 to 4.0).Conclusions: Current scientific evidence is insufficient to prove clinical benefits of vitamin D in preventing  acute viral bronchiolitis.