Clinical aspects of PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and adenitis) [Abstract in English]
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Data de Publicação: | 2006 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Scientia Medica (Porto Alegre. Online) |
Texto Completo: | https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1546 |
Resumo: | Purpose: The aim of this work was to present a literature review about PFAPA syndrome, focusing its clinical features, diagnosis and treatment. Data source: Articles indexed on MEDLINE published from 1984 to 2003 were reviewed. Data synthesis: PFAPA syndrome is a benign disease characterized by recurrent episodes of high fever, aphthous stomatitis, pharyngitis and cervical adenitis affecting children under age of five years. Children affected are healthy between the episodes, which recur every 28 days. Early administration of prednisone is effective in controlling symptoms, although patients can show spontaneous remission of clinical manifestations as they become older. There are no long-term sequelae. Conclusion: Correct diagnosis of PFAPA is important, especially to avoid misdiagnosis with Behçet syndrome, hypergammaglobulinemia D syndrome, familial Mediterranean fever and cyclic neutropenia. As confirmed PFAPA diagnosis, we have to explain parents about the benign character of this disease as well the possibility of spontaneous remission of its manifestations at puberty. KEY WORDS: RELAPSING FEVER; PHARYNGITIS; STOMATITIS, APHTHOUS; LYMPHADENITIS; CHILD. |
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Clinical aspects of PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and adenitis) [Abstract in English]Aspectos de interesse clínico sobre a síndrome PFAPA (febre periódica, estomatite aftosa, faringite e adenite)Purpose: The aim of this work was to present a literature review about PFAPA syndrome, focusing its clinical features, diagnosis and treatment. Data source: Articles indexed on MEDLINE published from 1984 to 2003 were reviewed. Data synthesis: PFAPA syndrome is a benign disease characterized by recurrent episodes of high fever, aphthous stomatitis, pharyngitis and cervical adenitis affecting children under age of five years. Children affected are healthy between the episodes, which recur every 28 days. Early administration of prednisone is effective in controlling symptoms, although patients can show spontaneous remission of clinical manifestations as they become older. There are no long-term sequelae. Conclusion: Correct diagnosis of PFAPA is important, especially to avoid misdiagnosis with Behçet syndrome, hypergammaglobulinemia D syndrome, familial Mediterranean fever and cyclic neutropenia. As confirmed PFAPA diagnosis, we have to explain parents about the benign character of this disease as well the possibility of spontaneous remission of its manifestations at puberty. KEY WORDS: RELAPSING FEVER; PHARYNGITIS; STOMATITIS, APHTHOUS; LYMPHADENITIS; CHILD. Objetivo: Apresentar uma revisão da literatura sobre a síndrome PFAPA, enfocando suas características clínicas, métodos diagnósticos e tratamento. Fonte de dados: Foram consultados artigos indexados no MEDLINE, publicados no período de 1984 a 2003. Síntese de dados: A síndrome PFAPA é uma enfermidade benigna, que se caracteriza por episódios recorrentes de febre alta, estomatite aftosa, faringite e adenite cervical em crianças de faixa etária inferior a cinco anos. As crianças apresentam-se saudáveis entre os episódios febris, cujo intervalo é, classicamente, de 28 dias. A prednisona aborta os sinais e sintomas quando administrada em fase inicial, porém os sintomas atenuam-se espontaneamente com o avanço da idade. Não são descritas seqüelas a longo prazo. Conclusões: Após a análise da literatura, fica clara a importância do correto diagnóstico da síndrome PFAPA e seu diagnóstico diferencial com a síndrome de Behçet, síndrome da imunoglobulinemia D, febre familiar do Mediterrâneo e neutropenia cíclica. Uma vez confirmado o diagnóstico, o profissional deve tranqüilizar e orientar os familiares, esclarecendo-os sobre a diminuição da recorrência dos quadros com o avanço da idade ou mesmo completa remissão com a chegada da puberdade. UNITERMOS: FEBRE RECORRENTE; FARINGITE; ESTOMATITE AFTOSA; LINFADENITE; CRIANÇA. Editora da PUCRS - ediPUCRS2006-10-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1546Scientia Medica; Vol. 15 No. 1 (2005)Scientia Medica; v. 15 n. 1 (2005)1980-61081806-5562reponame:Scientia Medica (Porto Alegre. Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSporhttps://revistaseletronicas.pucrs.br/scientiamedica/article/view/1546/1149Fonseca, Alisson A. R.Cherubini, Kareninfo:eu-repo/semantics/openAccess2018-08-08T21:48:24Zoai:ojs.revistaseletronicas.pucrs.br:article/1546Revistahttps://revistaseletronicas.pucrs.br/scientiamedica/PUBhttps://revistaseletronicas.pucrs.br/scientiamedica/oaiscientiamedica@pucrs.br || editora.periodicos@pucrs.br1980-61081806-5562opendoar:2018-08-08T21:48:24Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.none.fl_str_mv |
Clinical aspects of PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and adenitis) [Abstract in English] Aspectos de interesse clínico sobre a síndrome PFAPA (febre periódica, estomatite aftosa, faringite e adenite) |
title |
Clinical aspects of PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and adenitis) [Abstract in English] |
spellingShingle |
Clinical aspects of PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and adenitis) [Abstract in English] Fonseca, Alisson A. R. |
title_short |
Clinical aspects of PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and adenitis) [Abstract in English] |
title_full |
Clinical aspects of PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and adenitis) [Abstract in English] |
title_fullStr |
Clinical aspects of PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and adenitis) [Abstract in English] |
title_full_unstemmed |
Clinical aspects of PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and adenitis) [Abstract in English] |
title_sort |
Clinical aspects of PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis and adenitis) [Abstract in English] |
author |
Fonseca, Alisson A. R. |
author_facet |
Fonseca, Alisson A. R. Cherubini, Karen |
author_role |
author |
author2 |
Cherubini, Karen |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Fonseca, Alisson A. R. Cherubini, Karen |
description |
Purpose: The aim of this work was to present a literature review about PFAPA syndrome, focusing its clinical features, diagnosis and treatment. Data source: Articles indexed on MEDLINE published from 1984 to 2003 were reviewed. Data synthesis: PFAPA syndrome is a benign disease characterized by recurrent episodes of high fever, aphthous stomatitis, pharyngitis and cervical adenitis affecting children under age of five years. Children affected are healthy between the episodes, which recur every 28 days. Early administration of prednisone is effective in controlling symptoms, although patients can show spontaneous remission of clinical manifestations as they become older. There are no long-term sequelae. Conclusion: Correct diagnosis of PFAPA is important, especially to avoid misdiagnosis with Behçet syndrome, hypergammaglobulinemia D syndrome, familial Mediterranean fever and cyclic neutropenia. As confirmed PFAPA diagnosis, we have to explain parents about the benign character of this disease as well the possibility of spontaneous remission of its manifestations at puberty. KEY WORDS: RELAPSING FEVER; PHARYNGITIS; STOMATITIS, APHTHOUS; LYMPHADENITIS; CHILD. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-10-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1546 |
url |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1546 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://revistaseletronicas.pucrs.br/scientiamedica/article/view/1546/1149 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
publisher.none.fl_str_mv |
Editora da PUCRS - ediPUCRS |
dc.source.none.fl_str_mv |
Scientia Medica; Vol. 15 No. 1 (2005) Scientia Medica; v. 15 n. 1 (2005) 1980-6108 1806-5562 reponame:Scientia Medica (Porto Alegre. Online) instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) instacron:PUC_RS |
instname_str |
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
instacron_str |
PUC_RS |
institution |
PUC_RS |
reponame_str |
Scientia Medica (Porto Alegre. Online) |
collection |
Scientia Medica (Porto Alegre. Online) |
repository.name.fl_str_mv |
Scientia Medica (Porto Alegre. Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS) |
repository.mail.fl_str_mv |
scientiamedica@pucrs.br || editora.periodicos@pucrs.br |
_version_ |
1809101748353105920 |