Evaluation of ADAM10 levels and activity in different biological media

Detalhes bibliográficos
Autor(a) principal: Peron, Rafaela
Data de Publicação: 2020
Outros Autores: Vatanabe, Izabela Pereira, Manzine, Patricia Regina, Grigoli, Marina Mantellatto, Cominetti, Márcia Regina
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista Kairós (Online)
Texto Completo: https://revistas.pucsp.br/index.php/kairos/article/view/50705
Resumo: Alzheimer's disease (AD) affects millions of people worldwide and results from two major pathological hallmarks, neurofibrillary tangles and senile plaques. The latter are derived from the cleavage of the amyloid precursor protein (APP) by the amyloidogenic pathway, which is avoided by the  a-secretase ADAM10. This study aimed to evaluate ADAM10 levels and activity in different biological media of individuals with AD, comparing these findings with those obtained in subjects without cognitive impairment, in order to contribute to the diagnostic reinforcement of the disease. 
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spelling Evaluation of ADAM10 levels and activity in different biological mediaEvaluación de los niveles y actividad de ADAM10 en diferentes entornos biológicosAvaliação dos níveis e atividade da ADAM10 em diferentes meios biológicosADAM10BiomarcadorDoença de Alzheimer.ADAM10BiomarcadorEnfermedad de Alzheimer.ADAM10BiomarkerAlzheimer’s disease.Alzheimer's disease (AD) affects millions of people worldwide and results from two major pathological hallmarks, neurofibrillary tangles and senile plaques. The latter are derived from the cleavage of the amyloid precursor protein (APP) by the amyloidogenic pathway, which is avoided by the  a-secretase ADAM10. This study aimed to evaluate ADAM10 levels and activity in different biological media of individuals with AD, comparing these findings with those obtained in subjects without cognitive impairment, in order to contribute to the diagnostic reinforcement of the disease. La enfermedad de Alzheimer (EA) afecta a millones de personas en todo el mundo y es el resultado de dos hitos patológicos principales, ovillos neurofibrilares y placas seniles. Estos últimos se derivan de la escisión de la proteína precursora amiloide (APP) por la vía amiloidogénica, que es prevenida por AM-secretasa ADAM10. Este estudio buscó evaluar los niveles y actividad de ADAM10 en diferentes ambientes biológicos de individuos con EA, comparando estos hallazgos con los obtenidos en sujetos sin deterioro cognitivo, con el fin de colaborar para reforzar el diagnóstico de la enfermedad.A doença de Alzheimer (DA) afeta milhões de pessoas no mundo e resulta de dois marcos patológicos principais, os emaranhados neurofibrilares e a placas senis. Estas últimas derivam da clivagem da proteína precursora do amiloide (APP) pela via amiloidogênica, o que é evitado pela a-secretase ADAM10. Este estudo buscou avaliar níveis e atividade da ADAM10 em diferentes meios biológicos de indivíduos com DA, comparando estes achados com os obtidos em sujeitos sem alteração cognitiva, de modo a colaborar para o reforço diagnóstico da doença.  Pontifícia Universidade Católica de São Paulo2020-09-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistas.pucsp.br/index.php/kairos/article/view/5070510.23925/2176-901X.2020v23i0p83-95Revista Kairós-Gerontologia; v. 23 (2020): NÚMERO ESPECIAL 27 - REPRINTE 2019; 83-952176-901X1516-2567reponame:Revista Kairós (Online)instname:Pontifícia Universidade Católica de São Paulo (PUC-SP)instacron:PUC_SPporhttps://revistas.pucsp.br/index.php/kairos/article/view/50705/33125Copyright (c) 2020 Revista Kairós : Gerontologiainfo:eu-repo/semantics/openAccessPeron, RafaelaVatanabe, Izabela PereiraManzine, Patricia ReginaGrigoli, Marina MantellattoCominetti, Márcia Regina2020-10-10T02:22:02Zoai:ojs.pkp.sfu.ca:article/50705Revistahttp://revistas.pucsp.br/index.php/kairosPRIhttps://revistas.pucsp.br/kairos/oaikairos@pucsp.br||flalodo@terra.com.br|| contato@openjournalsolutions.com.br2176-901X1516-2567opendoar:2020-10-10T02:22:02Revista Kairós (Online) - Pontifícia Universidade Católica de São Paulo (PUC-SP)false
dc.title.none.fl_str_mv Evaluation of ADAM10 levels and activity in different biological media
Evaluación de los niveles y actividad de ADAM10 en diferentes entornos biológicos
Avaliação dos níveis e atividade da ADAM10 em diferentes meios biológicos
title Evaluation of ADAM10 levels and activity in different biological media
spellingShingle Evaluation of ADAM10 levels and activity in different biological media
Peron, Rafaela
ADAM10
Biomarcador
Doença de Alzheimer.
ADAM10
Biomarcador
Enfermedad de Alzheimer.
ADAM10
Biomarker
Alzheimer’s disease.
title_short Evaluation of ADAM10 levels and activity in different biological media
title_full Evaluation of ADAM10 levels and activity in different biological media
title_fullStr Evaluation of ADAM10 levels and activity in different biological media
title_full_unstemmed Evaluation of ADAM10 levels and activity in different biological media
title_sort Evaluation of ADAM10 levels and activity in different biological media
author Peron, Rafaela
author_facet Peron, Rafaela
Vatanabe, Izabela Pereira
Manzine, Patricia Regina
Grigoli, Marina Mantellatto
Cominetti, Márcia Regina
author_role author
author2 Vatanabe, Izabela Pereira
Manzine, Patricia Regina
Grigoli, Marina Mantellatto
Cominetti, Márcia Regina
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Peron, Rafaela
Vatanabe, Izabela Pereira
Manzine, Patricia Regina
Grigoli, Marina Mantellatto
Cominetti, Márcia Regina
dc.subject.por.fl_str_mv ADAM10
Biomarcador
Doença de Alzheimer.
ADAM10
Biomarcador
Enfermedad de Alzheimer.
ADAM10
Biomarker
Alzheimer’s disease.
topic ADAM10
Biomarcador
Doença de Alzheimer.
ADAM10
Biomarcador
Enfermedad de Alzheimer.
ADAM10
Biomarker
Alzheimer’s disease.
description Alzheimer's disease (AD) affects millions of people worldwide and results from two major pathological hallmarks, neurofibrillary tangles and senile plaques. The latter are derived from the cleavage of the amyloid precursor protein (APP) by the amyloidogenic pathway, which is avoided by the  a-secretase ADAM10. This study aimed to evaluate ADAM10 levels and activity in different biological media of individuals with AD, comparing these findings with those obtained in subjects without cognitive impairment, in order to contribute to the diagnostic reinforcement of the disease. 
publishDate 2020
dc.date.none.fl_str_mv 2020-09-30
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistas.pucsp.br/index.php/kairos/article/view/50705
10.23925/2176-901X.2020v23i0p83-95
url https://revistas.pucsp.br/index.php/kairos/article/view/50705
identifier_str_mv 10.23925/2176-901X.2020v23i0p83-95
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://revistas.pucsp.br/index.php/kairos/article/view/50705/33125
dc.rights.driver.fl_str_mv Copyright (c) 2020 Revista Kairós : Gerontologia
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2020 Revista Kairós : Gerontologia
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Pontifícia Universidade Católica de São Paulo
publisher.none.fl_str_mv Pontifícia Universidade Católica de São Paulo
dc.source.none.fl_str_mv Revista Kairós-Gerontologia; v. 23 (2020): NÚMERO ESPECIAL 27 - REPRINTE 2019; 83-95
2176-901X
1516-2567
reponame:Revista Kairós (Online)
instname:Pontifícia Universidade Católica de São Paulo (PUC-SP)
instacron:PUC_SP
instname_str Pontifícia Universidade Católica de São Paulo (PUC-SP)
instacron_str PUC_SP
institution PUC_SP
reponame_str Revista Kairós (Online)
collection Revista Kairós (Online)
repository.name.fl_str_mv Revista Kairós (Online) - Pontifícia Universidade Católica de São Paulo (PUC-SP)
repository.mail.fl_str_mv kairos@pucsp.br||flalodo@terra.com.br|| contato@openjournalsolutions.com.br
_version_ 1799128695246422016

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