Associação entre o Polimorfismo do Gene do Receptor da Ocitocina (OXTR) rs2254298, níveis de ocitocina, estilos de apego e traços de personalidade em idosos
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações da PUC_RS |
Texto Completo: | http://tede2.pucrs.br/tede2/handle/tede/9922 |
Resumo: | Introduction: oxytocin plays an important role in the body, being also associated with the modulation of different aspects of social behavior. The way attachment bonds are established, configure mental representations about the other, impact relationships and appear to influence personality structuring. Some studies suggest that genetic variations may be associated with this cascade of events. However, investigations in this area are still scarce and inconclusive. Objective: to identify the association between oxytocin receptor gene polymorphism (OXTR rs 2254298), serum oxytocin levels, attachment styles and personality traits in a sample of elderly people from Porto Alegre. Method: quantitative, cross-sectional, descriptive and analytical study. Sample composed of 108 elderly people of both sexes, with age range between 60 and 87 years, patients of the Family Health Strategy in Porto Alegre / RS. The variables investigated were: sociodemographic, biochemical marker, attachment styles, personality traits and genotype. The following instruments were used: General Questionnaire of the Brain Aging Program - PENCE for sociodemographic data; Relationship Scale Questionnaire - RSQ for attachment styles; Neo Five Factor Inventory - NEO-FFI-R for personality traits; Enzyme-Linked Immunosorbent Assay - ELISA for oxytocin level and Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP) for genotype. Results: a significant association was identified between oxytocin levels and safe attachment (p <0.05); between personality traits and attachment styles in the total sample and in both groups, analyzed separately. A significant difference was identified between attachment traits and styles in the relationship between men and women. A significant association was also identified between traits and styles of attachment with education level, in the total sample and in the group of women. Polymorphism was not significantly associated with any other variable. Conclusions: the results demonstrate an association between personality traits and attachment styles in the elderly, with the levels of oxytocin in this sample associated only with safe attachment. Even if, identified variations in the levels of oxytocin between the alleles, there was no significant difference. According to this study, there is no association between the OXTR polymorphism rs2254298 with any other variable. |
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Cataldo Neto, Alfredohttp://lattes.cnpq.br/9450739274205081http://lattes.cnpq.br/5608230452635630Nogueira, Guilherme Marcos2021-10-21T14:15:36Z2021-07-30http://tede2.pucrs.br/tede2/handle/tede/9922Introduction: oxytocin plays an important role in the body, being also associated with the modulation of different aspects of social behavior. The way attachment bonds are established, configure mental representations about the other, impact relationships and appear to influence personality structuring. Some studies suggest that genetic variations may be associated with this cascade of events. However, investigations in this area are still scarce and inconclusive. Objective: to identify the association between oxytocin receptor gene polymorphism (OXTR rs 2254298), serum oxytocin levels, attachment styles and personality traits in a sample of elderly people from Porto Alegre. Method: quantitative, cross-sectional, descriptive and analytical study. Sample composed of 108 elderly people of both sexes, with age range between 60 and 87 years, patients of the Family Health Strategy in Porto Alegre / RS. The variables investigated were: sociodemographic, biochemical marker, attachment styles, personality traits and genotype. The following instruments were used: General Questionnaire of the Brain Aging Program - PENCE for sociodemographic data; Relationship Scale Questionnaire - RSQ for attachment styles; Neo Five Factor Inventory - NEO-FFI-R for personality traits; Enzyme-Linked Immunosorbent Assay - ELISA for oxytocin level and Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP) for genotype. Results: a significant association was identified between oxytocin levels and safe attachment (p <0.05); between personality traits and attachment styles in the total sample and in both groups, analyzed separately. A significant difference was identified between attachment traits and styles in the relationship between men and women. A significant association was also identified between traits and styles of attachment with education level, in the total sample and in the group of women. Polymorphism was not significantly associated with any other variable. Conclusions: the results demonstrate an association between personality traits and attachment styles in the elderly, with the levels of oxytocin in this sample associated only with safe attachment. Even if, identified variations in the levels of oxytocin between the alleles, there was no significant difference. According to this study, there is no association between the OXTR polymorphism rs2254298 with any other variable.Introdução: a ocitocina desempenha importante papel no organismo, estando associada também na modulação de diferentes aspectos do comportamento social. A forma como se estabelecem os vínculos de apego, configuram as representações mentais acerca do outro, impactam nas relações e parecem influenciar na estruturação da personalidade. Alguns estudos sugerem que variações genéticas podem estar associadas a essa cascata de eventos. No entanto, as investigações nesse âmbito ainda são escassas e inconclusivas. Objetivo: identificar a associação entre o polimorfismo do gene do receptor da ocitocina (OXTR rs 2254298), níveis de ocitocina no soro, estilos de apego e traços de personalidade em uma amostra de idosos de Porto Alegre. Método: estudo quantitativo, transversal, descritivo e analítico. Amostra composta por 108 idosos de ambos os sexos, com variação etária entre 60 e 87 anos, pacientes da Estratégia de Saúde da Família em Porto Alegre/RS. As variáveis investigadas foram: sociodemográficas, marcador bioquímico, estilos de apego, traços de personalidade e genótipo. Foram utilizados os seguintes instrumentos: Questionário Geral do Programa de Envelhecimento Cerebral – PENCE para dados sociodemográficos; Relationship Scale Questionnaire – RSQ para estilos de apego; Neo Five Factor Inventory – NEO-FFI-R para traços de personalidade; Enzyme-Linked Immunosorbent Assay – ELISA para nível de ocitocina e Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP) para genótipo. Resultados: associação significativa foi identificada entre níveis de ocitocina e apego seguro (p<0,05); entre traços de personalidade e estilos de apego na amostra total e em ambos os grupos, analisados separadamente. Foi identificada diferença significativa entre traços e estilos de apego, na comparação entre homens e mulheres. Associação significativa foi identificada também entre traços e estilos de apego com nível de escolaridade, na amostra total e no grupo de mulheres. O polimorfismo não se associou significativamente com nenhuma outra variável. Conclusões: os resultados demonstram associação entre os traços de personalidade e estilos de apego nos idosos, estando os níveis de ocitocina dessa amostra associados somente com apego seguro. Mesmo que, identificada variações nos níveis de ocitocina entre os alelos, não houve diferença significativa. Não há, de acordo com esse estudo, associação entre o polimorfismo OXTR rs2254298 com nenhuma outra variável.Submitted by PPG Gerontologia Biomédica (geronbio@pucrs.br) on 2021-10-20T17:43:32Z No. of bitstreams: 1 NOGUEIRA_GUILHERME_MARCOS_TES.pdf: 6299812 bytes, checksum: e24d0eb6474d16e0945c6da3005caa9e (MD5)Approved for entry into archive by Sarajane Pan (sarajane.pan@pucrs.br) on 2021-10-21T14:11:45Z (GMT) No. of bitstreams: 1 NOGUEIRA_GUILHERME_MARCOS_TES.pdf: 6299812 bytes, checksum: e24d0eb6474d16e0945c6da3005caa9e (MD5)Made available in DSpace on 2021-10-21T14:15:36Z (GMT). No. of bitstreams: 1 NOGUEIRA_GUILHERME_MARCOS_TES.pdf: 6299812 bytes, checksum: e24d0eb6474d16e0945c6da3005caa9e (MD5) Previous issue date: 2021-07-30Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfhttp://tede2.pucrs.br:80/tede2/retrieve/182348/NOGUEIRA_GUILHERME_MARCOS_TES.pdf.jpgporPontifícia Universidade Católica do Rio Grande do SulPrograma de Pós-Graduação em Gerontologia BiomédicaPUCRSBrasilEscola de MedicinaIdosoOcitocinaPolimorfismo GenéticoTraços de PersonalidadeVínculo de ApegoCIENCIAS DA SAUDE::MEDICINAAssociação entre o Polimorfismo do Gene do Receptor da Ocitocina (OXTR) rs2254298, níveis de ocitocina, estilos de apego e traços de personalidade em idososinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisTrabalho não apresenta restrição para publicação8969645070886364160500600500600-224747486637135387-9693694523087866273590462550136975366info:eu-repo/semantics/openAccessreponame:Biblioteca Digital de Teses e Dissertações da PUC_RSinstname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSTHUMBNAILNOGUEIRA_GUILHERME_MARCOS_TES.pdf.jpgNOGUEIRA_GUILHERME_MARCOS_TES.pdf.jpgimage/jpeg6170http://tede2.pucrs.br/tede2/bitstream/tede/9922/3/NOGUEIRA_GUILHERME_MARCOS_TES.pdf.jpg827a63d1ac52068b1e667c02e728433aMD53TEXTNOGUEIRA_GUILHERME_MARCOS_TES.pdf.txtNOGUEIRA_GUILHERME_MARCOS_TES.pdf.txttext/plain354056http://tede2.pucrs.br/tede2/bitstream/tede/9922/4/NOGUEIRA_GUILHERME_MARCOS_TES.pdf.txt0527792210c9bf5327efba4aff6dab40MD54ORIGINALNOGUEIRA_GUILHERME_MARCOS_TES.pdfNOGUEIRA_GUILHERME_MARCOS_TES.pdfapplication/pdf6299812http://tede2.pucrs.br/tede2/bitstream/tede/9922/2/NOGUEIRA_GUILHERME_MARCOS_TES.pdfe24d0eb6474d16e0945c6da3005caa9eMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-8590http://tede2.pucrs.br/tede2/bitstream/tede/9922/1/license.txt220e11f2d3ba5354f917c7035aadef24MD51tede/99222021-10-22 13:00:20.564oai:tede2.pucrs.br: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Biblioteca Digital de Teses e Dissertaçõeshttp://tede2.pucrs.br/tede2/PRIhttps://tede2.pucrs.br/oai/requestbiblioteca.central@pucrs.br||opendoar:2021-10-22T15:00:20Biblioteca Digital de Teses e Dissertações da PUC_RS - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false |
dc.title.por.fl_str_mv |
Associação entre o Polimorfismo do Gene do Receptor da Ocitocina (OXTR) rs2254298, níveis de ocitocina, estilos de apego e traços de personalidade em idosos |
title |
Associação entre o Polimorfismo do Gene do Receptor da Ocitocina (OXTR) rs2254298, níveis de ocitocina, estilos de apego e traços de personalidade em idosos |
spellingShingle |
Associação entre o Polimorfismo do Gene do Receptor da Ocitocina (OXTR) rs2254298, níveis de ocitocina, estilos de apego e traços de personalidade em idosos Nogueira, Guilherme Marcos Idoso Ocitocina Polimorfismo Genético Traços de Personalidade Vínculo de Apego CIENCIAS DA SAUDE::MEDICINA |
title_short |
Associação entre o Polimorfismo do Gene do Receptor da Ocitocina (OXTR) rs2254298, níveis de ocitocina, estilos de apego e traços de personalidade em idosos |
title_full |
Associação entre o Polimorfismo do Gene do Receptor da Ocitocina (OXTR) rs2254298, níveis de ocitocina, estilos de apego e traços de personalidade em idosos |
title_fullStr |
Associação entre o Polimorfismo do Gene do Receptor da Ocitocina (OXTR) rs2254298, níveis de ocitocina, estilos de apego e traços de personalidade em idosos |
title_full_unstemmed |
Associação entre o Polimorfismo do Gene do Receptor da Ocitocina (OXTR) rs2254298, níveis de ocitocina, estilos de apego e traços de personalidade em idosos |
title_sort |
Associação entre o Polimorfismo do Gene do Receptor da Ocitocina (OXTR) rs2254298, níveis de ocitocina, estilos de apego e traços de personalidade em idosos |
author |
Nogueira, Guilherme Marcos |
author_facet |
Nogueira, Guilherme Marcos |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Cataldo Neto, Alfredo |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/9450739274205081 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/5608230452635630 |
dc.contributor.author.fl_str_mv |
Nogueira, Guilherme Marcos |
contributor_str_mv |
Cataldo Neto, Alfredo |
dc.subject.por.fl_str_mv |
Idoso Ocitocina Polimorfismo Genético Traços de Personalidade Vínculo de Apego |
topic |
Idoso Ocitocina Polimorfismo Genético Traços de Personalidade Vínculo de Apego CIENCIAS DA SAUDE::MEDICINA |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::MEDICINA |
description |
Introduction: oxytocin plays an important role in the body, being also associated with the modulation of different aspects of social behavior. The way attachment bonds are established, configure mental representations about the other, impact relationships and appear to influence personality structuring. Some studies suggest that genetic variations may be associated with this cascade of events. However, investigations in this area are still scarce and inconclusive. Objective: to identify the association between oxytocin receptor gene polymorphism (OXTR rs 2254298), serum oxytocin levels, attachment styles and personality traits in a sample of elderly people from Porto Alegre. Method: quantitative, cross-sectional, descriptive and analytical study. Sample composed of 108 elderly people of both sexes, with age range between 60 and 87 years, patients of the Family Health Strategy in Porto Alegre / RS. The variables investigated were: sociodemographic, biochemical marker, attachment styles, personality traits and genotype. The following instruments were used: General Questionnaire of the Brain Aging Program - PENCE for sociodemographic data; Relationship Scale Questionnaire - RSQ for attachment styles; Neo Five Factor Inventory - NEO-FFI-R for personality traits; Enzyme-Linked Immunosorbent Assay - ELISA for oxytocin level and Polymerase Chain Reaction and Restriction Fragment Length Polymorphism (PCR-RFLP) for genotype. Results: a significant association was identified between oxytocin levels and safe attachment (p <0.05); between personality traits and attachment styles in the total sample and in both groups, analyzed separately. A significant difference was identified between attachment traits and styles in the relationship between men and women. A significant association was also identified between traits and styles of attachment with education level, in the total sample and in the group of women. Polymorphism was not significantly associated with any other variable. Conclusions: the results demonstrate an association between personality traits and attachment styles in the elderly, with the levels of oxytocin in this sample associated only with safe attachment. Even if, identified variations in the levels of oxytocin between the alleles, there was no significant difference. According to this study, there is no association between the OXTR polymorphism rs2254298 with any other variable. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-10-21T14:15:36Z |
dc.date.issued.fl_str_mv |
2021-07-30 |
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info:eu-repo/semantics/publishedVersion |
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por |
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por |
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8969645070886364160 |
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500 600 500 600 |
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