Real-world evidence from a European cohort study of patients with treatment resistant depression

Detalhes bibliográficos
Autor(a) principal: Heerlein, K.
Data de Publicação: 2021
Outros Autores: Young, A. H., Otte, C., Frodl, T., Degraeve, G., Hagedoorn, W., Oliveira-Maia, A. J., Perez Sola, V., Rathod, S., Rosso, G., Sierra, P., Morrens, J., Van Dooren, G., Gali, Y., Perugi, G.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/147432
Resumo: Funding: This study was sponsored by Janssen EMEA. This article was based on the original study 54135419DEP4001 sponsored by Janssen EMEA. Support for third-party writing assistance for this article, provided by Julia Stevens, Ph.D., and Emma Phillips, Ph.D., Costello Medical, UK, was funded by Janssen EMEA in accordance with Good Publication Practice (GPP3) guidelines (http://www.ismpp.org/gpp3).
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spelling Real-world evidence from a European cohort study of patients with treatment resistant depressionBaseline patient characteristics: Patient characteristics in treatment resistant depressionDisease burdenHealth-related quality of lifeMajor depressive disorderObservational studyPatient-reported outcomesSocio-economic statusClinical PsychologyPsychiatry and Mental healthSDG 3 - Good Health and Well-beingFunding: This study was sponsored by Janssen EMEA. This article was based on the original study 54135419DEP4001 sponsored by Janssen EMEA. Support for third-party writing assistance for this article, provided by Julia Stevens, Ph.D., and Emma Phillips, Ph.D., Costello Medical, UK, was funded by Janssen EMEA in accordance with Good Publication Practice (GPP3) guidelines (http://www.ismpp.org/gpp3).Background: Treatment resistant depression (TRD; failure to respond to ≥2 treatments) affects ~20% of patients with major depressive disorder (MDD). Real-world data could help describe patient characteristics and TRD disease burden, to assess the unmet needs of TRD patients in Europe. Methods: This observational study collected data from adults with moderate to severe TRD initiating a new treatment for depression, according to local standards of care. At baseline, socio-demographic characteristics, medical history, prior and current treatments were recorded. Disease severity, health-related quality of life (HRQoL), functionality and productivity were assessed. Results: Overall, 411 eligible patients were enrolled across seven European countries. Mean (standard deviation [SD]) patient age was 51.0 (10.8) years; 62.3% were female. Long-term sick leave was reported by 19.0% of patients; 30.2% were unemployed. The mean (SD) duration of the current episode was 2.6 (3.9) years. At baseline, mean (SD) HRQoL scores for EuroQoL 5-dimension 5-level (UK tariff) and EQ-Visual Analog Scale were 0.41 (0.25) and 41.1 (18.7), respectively. The Work Productivity and Activity Impairment questionnaire demonstrated mean (SD) absenteeism of 57.0% (44.9%) and presenteeism of 54.7% (29.5%); mean (SD) overall work impairment was 60.5% (29.9%). Limitations: Key limitations are small cohort size, absence of a control group and generalizability to countries with different healthcare models. Conclusions: TRD patients had a high disease burden, low HRQoL and reduced function and productivity, with a substantial proportion unable to work. This demonstrates an unmet treatment need in TRD patients that, if addressed, could reduce the heavy personal and societal burden.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNHeerlein, K.Young, A. H.Otte, C.Frodl, T.Degraeve, G.Hagedoorn, W.Oliveira-Maia, A. J.Perez Sola, V.Rathod, S.Rosso, G.Sierra, P.Morrens, J.Van Dooren, G.Gali, Y.Perugi, G.2023-01-12T22:16:01Z2021-03-152021-03-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://hdl.handle.net/10362/147432eng0165-0327PURE: 27961260https://doi.org/10.1016/j.jad.2020.11.124info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-10T16:11:22ZPortal AgregadorONG
dc.title.none.fl_str_mv Real-world evidence from a European cohort study of patients with treatment resistant depression
Baseline patient characteristics: Patient characteristics in treatment resistant depression
title Real-world evidence from a European cohort study of patients with treatment resistant depression
spellingShingle Real-world evidence from a European cohort study of patients with treatment resistant depression
Heerlein, K.
Disease burden
Health-related quality of life
Major depressive disorder
Observational study
Patient-reported outcomes
Socio-economic status
Clinical Psychology
Psychiatry and Mental health
SDG 3 - Good Health and Well-being
title_short Real-world evidence from a European cohort study of patients with treatment resistant depression
title_full Real-world evidence from a European cohort study of patients with treatment resistant depression
title_fullStr Real-world evidence from a European cohort study of patients with treatment resistant depression
title_full_unstemmed Real-world evidence from a European cohort study of patients with treatment resistant depression
title_sort Real-world evidence from a European cohort study of patients with treatment resistant depression
author Heerlein, K.
author_facet Heerlein, K.
Young, A. H.
Otte, C.
Frodl, T.
Degraeve, G.
Hagedoorn, W.
Oliveira-Maia, A. J.
Perez Sola, V.
Rathod, S.
Rosso, G.
Sierra, P.
Morrens, J.
Van Dooren, G.
Gali, Y.
Perugi, G.
author_role author
author2 Young, A. H.
Otte, C.
Frodl, T.
Degraeve, G.
Hagedoorn, W.
Oliveira-Maia, A. J.
Perez Sola, V.
Rathod, S.
Rosso, G.
Sierra, P.
Morrens, J.
Van Dooren, G.
Gali, Y.
Perugi, G.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Heerlein, K.
Young, A. H.
Otte, C.
Frodl, T.
Degraeve, G.
Hagedoorn, W.
Oliveira-Maia, A. J.
Perez Sola, V.
Rathod, S.
Rosso, G.
Sierra, P.
Morrens, J.
Van Dooren, G.
Gali, Y.
Perugi, G.
dc.subject.por.fl_str_mv Disease burden
Health-related quality of life
Major depressive disorder
Observational study
Patient-reported outcomes
Socio-economic status
Clinical Psychology
Psychiatry and Mental health
SDG 3 - Good Health and Well-being
topic Disease burden
Health-related quality of life
Major depressive disorder
Observational study
Patient-reported outcomes
Socio-economic status
Clinical Psychology
Psychiatry and Mental health
SDG 3 - Good Health and Well-being
description Funding: This study was sponsored by Janssen EMEA. This article was based on the original study 54135419DEP4001 sponsored by Janssen EMEA. Support for third-party writing assistance for this article, provided by Julia Stevens, Ph.D., and Emma Phillips, Ph.D., Costello Medical, UK, was funded by Janssen EMEA in accordance with Good Publication Practice (GPP3) guidelines (http://www.ismpp.org/gpp3).
publishDate 2021
dc.date.none.fl_str_mv 2021-03-15
2021-03-15T00:00:00Z
2023-01-12T22:16:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/147432
url http://hdl.handle.net/10362/147432
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0165-0327
PURE: 27961260
https://doi.org/10.1016/j.jad.2020.11.124
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.mail.fl_str_mv
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