Real-world evidence from a European cohort study of patients with treatment resistant depression
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/147432 |
Resumo: | Funding: This study was sponsored by Janssen EMEA. This article was based on the original study 54135419DEP4001 sponsored by Janssen EMEA. Support for third-party writing assistance for this article, provided by Julia Stevens, Ph.D., and Emma Phillips, Ph.D., Costello Medical, UK, was funded by Janssen EMEA in accordance with Good Publication Practice (GPP3) guidelines (http://www.ismpp.org/gpp3). |
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Real-world evidence from a European cohort study of patients with treatment resistant depressionBaseline patient characteristics: Patient characteristics in treatment resistant depressionDisease burdenHealth-related quality of lifeMajor depressive disorderObservational studyPatient-reported outcomesSocio-economic statusClinical PsychologyPsychiatry and Mental healthSDG 3 - Good Health and Well-beingFunding: This study was sponsored by Janssen EMEA. This article was based on the original study 54135419DEP4001 sponsored by Janssen EMEA. Support for third-party writing assistance for this article, provided by Julia Stevens, Ph.D., and Emma Phillips, Ph.D., Costello Medical, UK, was funded by Janssen EMEA in accordance with Good Publication Practice (GPP3) guidelines (http://www.ismpp.org/gpp3).Background: Treatment resistant depression (TRD; failure to respond to ≥2 treatments) affects ~20% of patients with major depressive disorder (MDD). Real-world data could help describe patient characteristics and TRD disease burden, to assess the unmet needs of TRD patients in Europe. Methods: This observational study collected data from adults with moderate to severe TRD initiating a new treatment for depression, according to local standards of care. At baseline, socio-demographic characteristics, medical history, prior and current treatments were recorded. Disease severity, health-related quality of life (HRQoL), functionality and productivity were assessed. Results: Overall, 411 eligible patients were enrolled across seven European countries. Mean (standard deviation [SD]) patient age was 51.0 (10.8) years; 62.3% were female. Long-term sick leave was reported by 19.0% of patients; 30.2% were unemployed. The mean (SD) duration of the current episode was 2.6 (3.9) years. At baseline, mean (SD) HRQoL scores for EuroQoL 5-dimension 5-level (UK tariff) and EQ-Visual Analog Scale were 0.41 (0.25) and 41.1 (18.7), respectively. The Work Productivity and Activity Impairment questionnaire demonstrated mean (SD) absenteeism of 57.0% (44.9%) and presenteeism of 54.7% (29.5%); mean (SD) overall work impairment was 60.5% (29.9%). Limitations: Key limitations are small cohort size, absence of a control group and generalizability to countries with different healthcare models. Conclusions: TRD patients had a high disease burden, low HRQoL and reduced function and productivity, with a substantial proportion unable to work. This demonstrates an unmet treatment need in TRD patients that, if addressed, could reduce the heavy personal and societal burden.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNHeerlein, K.Young, A. H.Otte, C.Frodl, T.Degraeve, G.Hagedoorn, W.Oliveira-Maia, A. J.Perez Sola, V.Rathod, S.Rosso, G.Sierra, P.Morrens, J.Van Dooren, G.Gali, Y.Perugi, G.2023-01-12T22:16:01Z2021-03-152021-03-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8application/pdfhttp://hdl.handle.net/10362/147432eng0165-0327PURE: 27961260https://doi.org/10.1016/j.jad.2020.11.124info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:28:32Zoai:run.unl.pt:10362/147432Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:55.443337Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Real-world evidence from a European cohort study of patients with treatment resistant depression Baseline patient characteristics: Patient characteristics in treatment resistant depression |
| title |
Real-world evidence from a European cohort study of patients with treatment resistant depression |
| spellingShingle |
Real-world evidence from a European cohort study of patients with treatment resistant depression Heerlein, K. Disease burden Health-related quality of life Major depressive disorder Observational study Patient-reported outcomes Socio-economic status Clinical Psychology Psychiatry and Mental health SDG 3 - Good Health and Well-being |
| title_short |
Real-world evidence from a European cohort study of patients with treatment resistant depression |
| title_full |
Real-world evidence from a European cohort study of patients with treatment resistant depression |
| title_fullStr |
Real-world evidence from a European cohort study of patients with treatment resistant depression |
| title_full_unstemmed |
Real-world evidence from a European cohort study of patients with treatment resistant depression |
| title_sort |
Real-world evidence from a European cohort study of patients with treatment resistant depression |
| author |
Heerlein, K. |
| author_facet |
Heerlein, K. Young, A. H. Otte, C. Frodl, T. Degraeve, G. Hagedoorn, W. Oliveira-Maia, A. J. Perez Sola, V. Rathod, S. Rosso, G. Sierra, P. Morrens, J. Van Dooren, G. Gali, Y. Perugi, G. |
| author_role |
author |
| author2 |
Young, A. H. Otte, C. Frodl, T. Degraeve, G. Hagedoorn, W. Oliveira-Maia, A. J. Perez Sola, V. Rathod, S. Rosso, G. Sierra, P. Morrens, J. Van Dooren, G. Gali, Y. Perugi, G. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Heerlein, K. Young, A. H. Otte, C. Frodl, T. Degraeve, G. Hagedoorn, W. Oliveira-Maia, A. J. Perez Sola, V. Rathod, S. Rosso, G. Sierra, P. Morrens, J. Van Dooren, G. Gali, Y. Perugi, G. |
| dc.subject.por.fl_str_mv |
Disease burden Health-related quality of life Major depressive disorder Observational study Patient-reported outcomes Socio-economic status Clinical Psychology Psychiatry and Mental health SDG 3 - Good Health and Well-being |
| topic |
Disease burden Health-related quality of life Major depressive disorder Observational study Patient-reported outcomes Socio-economic status Clinical Psychology Psychiatry and Mental health SDG 3 - Good Health and Well-being |
| description |
Funding: This study was sponsored by Janssen EMEA. This article was based on the original study 54135419DEP4001 sponsored by Janssen EMEA. Support for third-party writing assistance for this article, provided by Julia Stevens, Ph.D., and Emma Phillips, Ph.D., Costello Medical, UK, was funded by Janssen EMEA in accordance with Good Publication Practice (GPP3) guidelines (http://www.ismpp.org/gpp3). |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-03-15 2021-03-15T00:00:00Z 2023-01-12T22:16:01Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/147432 |
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http://hdl.handle.net/10362/147432 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
0165-0327 PURE: 27961260 https://doi.org/10.1016/j.jad.2020.11.124 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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8 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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