Real-world evidence from a European cohort study of patients with treatment resistant depression
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/120551 |
Resumo: | BACKGROUND: Treatment resistant depression (TRD) characterizes a subgroup of 10-30% of patients with major depressive disorder, and is associated with considerable morbidity and mortality. A consensus treatment for TRD does not exist, which often leads to wide variations in treatment strategies. Real-world studies on treatment patterns and outcomes in TRD patients in Europe are lacking and could help elucidate current treatment strategies and their efficacy. METHODS: This non-interventional cohort study of patients with TRD (defined as treatment failure on ≥2 oral antidepressants given at adequate dose and duration) with moderate to severe depression collected real-world data on treatment patterns and outcomes in several European countries. Patients were started on a new treatment for depression according to routine clinical practice. RESULTS: Among 411 patients enrolled, after 6 months, only 16.7% achieved remission and 73.5% showed no response. At Month 12, while 19.2% achieved remission and 69.2% showed no response, 33.3% of those in remission at Month 6 were no longer in remission. Pharmacological treatments employed were heterogenous; 54 different drugs were recorded at baseline, and the top 5 treatment types according to drug classes accounted for 40.0% of patients. Even though remission rates were very low, at Month 12, 60.0% of patients had not changed treatment since enrolment. CONCLUSIONS: The heterogeneity of treatments highlights a lack of consensus. Moreover, despite low response rates, patients often remained on treatments for substantial periods of time. These data further support existence of an unmet treatment need for TRD patients in Europe. |
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Real-world evidence from a European cohort study of patients with treatment resistant depressionTreatment patterns and clinical outcomesClinical PsychologyPsychiatry and Mental healthSDG 3 - Good Health and Well-beingBACKGROUND: Treatment resistant depression (TRD) characterizes a subgroup of 10-30% of patients with major depressive disorder, and is associated with considerable morbidity and mortality. A consensus treatment for TRD does not exist, which often leads to wide variations in treatment strategies. Real-world studies on treatment patterns and outcomes in TRD patients in Europe are lacking and could help elucidate current treatment strategies and their efficacy. METHODS: This non-interventional cohort study of patients with TRD (defined as treatment failure on ≥2 oral antidepressants given at adequate dose and duration) with moderate to severe depression collected real-world data on treatment patterns and outcomes in several European countries. Patients were started on a new treatment for depression according to routine clinical practice. RESULTS: Among 411 patients enrolled, after 6 months, only 16.7% achieved remission and 73.5% showed no response. At Month 12, while 19.2% achieved remission and 69.2% showed no response, 33.3% of those in remission at Month 6 were no longer in remission. Pharmacological treatments employed were heterogenous; 54 different drugs were recorded at baseline, and the top 5 treatment types according to drug classes accounted for 40.0% of patients. Even though remission rates were very low, at Month 12, 60.0% of patients had not changed treatment since enrolment. CONCLUSIONS: The heterogeneity of treatments highlights a lack of consensus. Moreover, despite low response rates, patients often remained on treatments for substantial periods of time. These data further support existence of an unmet treatment need for TRD patients in Europe.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNHeerlein, K.Perugi, G.Otte, C.Frodl, T.Degraeve, G.Hagedoorn, W.Oliveira-Maia, A. J.Perez Sola, V.Rathod, S.Rosso, G.Sierra, P.Malynn, S.Morrens, J.Verrijcken, C.Gonzalez, B.Young, A. H.2021-07-05T22:18:28Z2021-07-012021-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/120551eng0165-0327PURE: 32313860https://doi.org/10.1016/j.jad.2021.03.073info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:03:04Zoai:run.unl.pt:10362/120551Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:44:23.192316Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Real-world evidence from a European cohort study of patients with treatment resistant depression Treatment patterns and clinical outcomes |
title |
Real-world evidence from a European cohort study of patients with treatment resistant depression |
spellingShingle |
Real-world evidence from a European cohort study of patients with treatment resistant depression Heerlein, K. Clinical Psychology Psychiatry and Mental health SDG 3 - Good Health and Well-being |
title_short |
Real-world evidence from a European cohort study of patients with treatment resistant depression |
title_full |
Real-world evidence from a European cohort study of patients with treatment resistant depression |
title_fullStr |
Real-world evidence from a European cohort study of patients with treatment resistant depression |
title_full_unstemmed |
Real-world evidence from a European cohort study of patients with treatment resistant depression |
title_sort |
Real-world evidence from a European cohort study of patients with treatment resistant depression |
author |
Heerlein, K. |
author_facet |
Heerlein, K. Perugi, G. Otte, C. Frodl, T. Degraeve, G. Hagedoorn, W. Oliveira-Maia, A. J. Perez Sola, V. Rathod, S. Rosso, G. Sierra, P. Malynn, S. Morrens, J. Verrijcken, C. Gonzalez, B. Young, A. H. |
author_role |
author |
author2 |
Perugi, G. Otte, C. Frodl, T. Degraeve, G. Hagedoorn, W. Oliveira-Maia, A. J. Perez Sola, V. Rathod, S. Rosso, G. Sierra, P. Malynn, S. Morrens, J. Verrijcken, C. Gonzalez, B. Young, A. H. |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
dc.contributor.author.fl_str_mv |
Heerlein, K. Perugi, G. Otte, C. Frodl, T. Degraeve, G. Hagedoorn, W. Oliveira-Maia, A. J. Perez Sola, V. Rathod, S. Rosso, G. Sierra, P. Malynn, S. Morrens, J. Verrijcken, C. Gonzalez, B. Young, A. H. |
dc.subject.por.fl_str_mv |
Clinical Psychology Psychiatry and Mental health SDG 3 - Good Health and Well-being |
topic |
Clinical Psychology Psychiatry and Mental health SDG 3 - Good Health and Well-being |
description |
BACKGROUND: Treatment resistant depression (TRD) characterizes a subgroup of 10-30% of patients with major depressive disorder, and is associated with considerable morbidity and mortality. A consensus treatment for TRD does not exist, which often leads to wide variations in treatment strategies. Real-world studies on treatment patterns and outcomes in TRD patients in Europe are lacking and could help elucidate current treatment strategies and their efficacy. METHODS: This non-interventional cohort study of patients with TRD (defined as treatment failure on ≥2 oral antidepressants given at adequate dose and duration) with moderate to severe depression collected real-world data on treatment patterns and outcomes in several European countries. Patients were started on a new treatment for depression according to routine clinical practice. RESULTS: Among 411 patients enrolled, after 6 months, only 16.7% achieved remission and 73.5% showed no response. At Month 12, while 19.2% achieved remission and 69.2% showed no response, 33.3% of those in remission at Month 6 were no longer in remission. Pharmacological treatments employed were heterogenous; 54 different drugs were recorded at baseline, and the top 5 treatment types according to drug classes accounted for 40.0% of patients. Even though remission rates were very low, at Month 12, 60.0% of patients had not changed treatment since enrolment. CONCLUSIONS: The heterogeneity of treatments highlights a lack of consensus. Moreover, despite low response rates, patients often remained on treatments for substantial periods of time. These data further support existence of an unmet treatment need for TRD patients in Europe. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-05T22:18:28Z 2021-07-01 2021-07-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/120551 |
url |
http://hdl.handle.net/10362/120551 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0165-0327 PURE: 32313860 https://doi.org/10.1016/j.jad.2021.03.073 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
11 application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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