Real-world evidence from a European cohort study of patients with treatment resistant depression

Detalhes bibliográficos
Autor(a) principal: Heerlein, K.
Data de Publicação: 2021
Outros Autores: Perugi, G., Otte, C., Frodl, T., Degraeve, G., Hagedoorn, W., Oliveira-Maia, A. J., Perez Sola, V., Rathod, S., Rosso, G., Sierra, P., Malynn, S., Morrens, J., Verrijcken, C., Gonzalez, B., Young, A. H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/120551
Resumo: BACKGROUND: Treatment resistant depression (TRD) characterizes a subgroup of 10-30% of patients with major depressive disorder, and is associated with considerable morbidity and mortality. A consensus treatment for TRD does not exist, which often leads to wide variations in treatment strategies. Real-world studies on treatment patterns and outcomes in TRD patients in Europe are lacking and could help elucidate current treatment strategies and their efficacy. METHODS: This non-interventional cohort study of patients with TRD (defined as treatment failure on ≥2 oral antidepressants given at adequate dose and duration) with moderate to severe depression collected real-world data on treatment patterns and outcomes in several European countries. Patients were started on a new treatment for depression according to routine clinical practice. RESULTS: Among 411 patients enrolled, after 6 months, only 16.7% achieved remission and 73.5% showed no response. At Month 12, while 19.2% achieved remission and 69.2% showed no response, 33.3% of those in remission at Month 6 were no longer in remission. Pharmacological treatments employed were heterogenous; 54 different drugs were recorded at baseline, and the top 5 treatment types according to drug classes accounted for 40.0% of patients. Even though remission rates were very low, at Month 12, 60.0% of patients had not changed treatment since enrolment. CONCLUSIONS: The heterogeneity of treatments highlights a lack of consensus. Moreover, despite low response rates, patients often remained on treatments for substantial periods of time. These data further support existence of an unmet treatment need for TRD patients in Europe.
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spelling Real-world evidence from a European cohort study of patients with treatment resistant depressionTreatment patterns and clinical outcomesClinical PsychologyPsychiatry and Mental healthSDG 3 - Good Health and Well-beingBACKGROUND: Treatment resistant depression (TRD) characterizes a subgroup of 10-30% of patients with major depressive disorder, and is associated with considerable morbidity and mortality. A consensus treatment for TRD does not exist, which often leads to wide variations in treatment strategies. Real-world studies on treatment patterns and outcomes in TRD patients in Europe are lacking and could help elucidate current treatment strategies and their efficacy. METHODS: This non-interventional cohort study of patients with TRD (defined as treatment failure on ≥2 oral antidepressants given at adequate dose and duration) with moderate to severe depression collected real-world data on treatment patterns and outcomes in several European countries. Patients were started on a new treatment for depression according to routine clinical practice. RESULTS: Among 411 patients enrolled, after 6 months, only 16.7% achieved remission and 73.5% showed no response. At Month 12, while 19.2% achieved remission and 69.2% showed no response, 33.3% of those in remission at Month 6 were no longer in remission. Pharmacological treatments employed were heterogenous; 54 different drugs were recorded at baseline, and the top 5 treatment types according to drug classes accounted for 40.0% of patients. Even though remission rates were very low, at Month 12, 60.0% of patients had not changed treatment since enrolment. CONCLUSIONS: The heterogeneity of treatments highlights a lack of consensus. Moreover, despite low response rates, patients often remained on treatments for substantial periods of time. These data further support existence of an unmet treatment need for TRD patients in Europe.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNHeerlein, K.Perugi, G.Otte, C.Frodl, T.Degraeve, G.Hagedoorn, W.Oliveira-Maia, A. J.Perez Sola, V.Rathod, S.Rosso, G.Sierra, P.Malynn, S.Morrens, J.Verrijcken, C.Gonzalez, B.Young, A. H.2021-07-05T22:18:28Z2021-07-012021-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/120551eng0165-0327PURE: 32313860https://doi.org/10.1016/j.jad.2021.03.073info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:03:04Zoai:run.unl.pt:10362/120551Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:44:23.192316Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Real-world evidence from a European cohort study of patients with treatment resistant depression
Treatment patterns and clinical outcomes
title Real-world evidence from a European cohort study of patients with treatment resistant depression
spellingShingle Real-world evidence from a European cohort study of patients with treatment resistant depression
Heerlein, K.
Clinical Psychology
Psychiatry and Mental health
SDG 3 - Good Health and Well-being
title_short Real-world evidence from a European cohort study of patients with treatment resistant depression
title_full Real-world evidence from a European cohort study of patients with treatment resistant depression
title_fullStr Real-world evidence from a European cohort study of patients with treatment resistant depression
title_full_unstemmed Real-world evidence from a European cohort study of patients with treatment resistant depression
title_sort Real-world evidence from a European cohort study of patients with treatment resistant depression
author Heerlein, K.
author_facet Heerlein, K.
Perugi, G.
Otte, C.
Frodl, T.
Degraeve, G.
Hagedoorn, W.
Oliveira-Maia, A. J.
Perez Sola, V.
Rathod, S.
Rosso, G.
Sierra, P.
Malynn, S.
Morrens, J.
Verrijcken, C.
Gonzalez, B.
Young, A. H.
author_role author
author2 Perugi, G.
Otte, C.
Frodl, T.
Degraeve, G.
Hagedoorn, W.
Oliveira-Maia, A. J.
Perez Sola, V.
Rathod, S.
Rosso, G.
Sierra, P.
Malynn, S.
Morrens, J.
Verrijcken, C.
Gonzalez, B.
Young, A. H.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Heerlein, K.
Perugi, G.
Otte, C.
Frodl, T.
Degraeve, G.
Hagedoorn, W.
Oliveira-Maia, A. J.
Perez Sola, V.
Rathod, S.
Rosso, G.
Sierra, P.
Malynn, S.
Morrens, J.
Verrijcken, C.
Gonzalez, B.
Young, A. H.
dc.subject.por.fl_str_mv Clinical Psychology
Psychiatry and Mental health
SDG 3 - Good Health and Well-being
topic Clinical Psychology
Psychiatry and Mental health
SDG 3 - Good Health and Well-being
description BACKGROUND: Treatment resistant depression (TRD) characterizes a subgroup of 10-30% of patients with major depressive disorder, and is associated with considerable morbidity and mortality. A consensus treatment for TRD does not exist, which often leads to wide variations in treatment strategies. Real-world studies on treatment patterns and outcomes in TRD patients in Europe are lacking and could help elucidate current treatment strategies and their efficacy. METHODS: This non-interventional cohort study of patients with TRD (defined as treatment failure on ≥2 oral antidepressants given at adequate dose and duration) with moderate to severe depression collected real-world data on treatment patterns and outcomes in several European countries. Patients were started on a new treatment for depression according to routine clinical practice. RESULTS: Among 411 patients enrolled, after 6 months, only 16.7% achieved remission and 73.5% showed no response. At Month 12, while 19.2% achieved remission and 69.2% showed no response, 33.3% of those in remission at Month 6 were no longer in remission. Pharmacological treatments employed were heterogenous; 54 different drugs were recorded at baseline, and the top 5 treatment types according to drug classes accounted for 40.0% of patients. Even though remission rates were very low, at Month 12, 60.0% of patients had not changed treatment since enrolment. CONCLUSIONS: The heterogeneity of treatments highlights a lack of consensus. Moreover, despite low response rates, patients often remained on treatments for substantial periods of time. These data further support existence of an unmet treatment need for TRD patients in Europe.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-05T22:18:28Z
2021-07-01
2021-07-01T00:00:00Z
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dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/120551
url http://hdl.handle.net/10362/120551
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0165-0327
PURE: 32313860
https://doi.org/10.1016/j.jad.2021.03.073
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dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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