Global, regional, and national burden of meningitis and its aetiologies, 1990 2019: a systematic analysis for the Global Burden of Disease Study 2019
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/61982 |
Resumo: | Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. |
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Global, regional, and national burden of meningitis and its aetiologies, 1990 2019: a systematic analysis for the Global Burden of Disease Study 2019Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.Background Although meningitis is largely preventable, it still causes hundreds of thousands of deaths globally each year. WHO set ambitious goals to reduce meningitis cases by 2030, and assessing trends in the global meningitis burden can help track progress and identify gaps in achieving these goals. Using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we aimed to assess incident cases and deaths due to acute infectious meningitis by aetiology and age from 1990 to 2019, for 204 countries and territories. Methods We modelled meningitis mortality using vital registration, verbal autopsy, sample-based vital registration, and mortality surveillance data. Meningitis morbidity was modelled with a Bayesian compartmental model, using data from the published literature identified by a systematic review, as well as surveillance data, inpatient hospital admissions, health insurance claims, and cause-specific meningitis mortality estimates. For aetiology estimation, data from multiple causes of death, vital registration, hospital discharge, microbial laboratory, and literature studies were analysed by use of a network analysis model to estimate the proportion of meningitis deaths and cases attributable to the following aetiologies: Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae, group B Streptococcus, Escherichia coli, Klebsiella pneumoniae, Listeria monocytogenes, Staphylococcus aureus, viruses, and a residual other pathogen category. Findings In 2019, there were an estimated 236 000 deaths (95% uncertainty interval [UI] 204 000–277 000) and 2·51 million (2·11–2·99) incident cases due to meningitis globally. The burden was greatest in children younger than 5 years, with 112 000 deaths (87 400–145 000) and 1·28 million incident cases (0·947–1·71) in 2019. Age-standardised mortality rates decreased from 7·5 (6·6–8·4) per 100 000 population in 1990 to 3·3 (2·8–3·9) per 100 000 population in 2019. The highest proportion of total all-age meningitis deaths in 2019 was attributable to S pneumoniae (18·1% [17·1–19·2]), followed by N meningitidis (13·6% [12·7–14·4]) and K pneumoniae (12·2% [10·2–14·3]). Between 1990 and 2019, H influenzae showed the largest reduction in the number of deaths among children younger than 5 years (76·5% [69·5–81·8]), followed by N meningitidis (72·3% [64·4–78·5]) and viruses (58·2% [47·1–67·3]). Interpretation Substantial progress has been made in reducing meningitis mortality over the past three decades. However, more meningitis-related deaths might be prevented by quickly scaling up immunisation and expanding access to health services. Further reduction in the global meningitis burden should be possible through low-cost multivalent vaccines, increased access to accurate and rapid diagnostic assays, enhanced surveillance, and early treatment.Bill & Melinda Gates FoundationElsevierRepositório da Universidade de LisboaWunrow, Han YongBender, Rose GVongpradith, AvinaSirota, Sarah BrookeSwetschinski, Lucien RNovotney, AmandaGray, Authia PPerdigão, JoãoGBD 2019 Meningitis Antimicrobial Resistance Collaborators2024-01-19T14:54:46Z2023-082023-12-29T12:16:49Z2023-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/61982engWunrow HY, Bender RG, Vongpradith A, Sirota SB, Swetschinski LR, Novotney A, et al. Global, regional, and national burden of meningitis and its aetiologies, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Neurology [Internet]. agosto de 2023;22(8):685–711. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S14744422230019531474-4422cv-prod-344010710.1016/s1474-4422(23)00195-3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-22T01:21:15Zoai:repositorio.ul.pt:10451/61982Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:56:19.810121Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Global, regional, and national burden of meningitis and its aetiologies, 1990 2019: a systematic analysis for the Global Burden of Disease Study 2019 |
| title |
Global, regional, and national burden of meningitis and its aetiologies, 1990 2019: a systematic analysis for the Global Burden of Disease Study 2019 |
| spellingShingle |
Global, regional, and national burden of meningitis and its aetiologies, 1990 2019: a systematic analysis for the Global Burden of Disease Study 2019 Wunrow, Han Yong |
| title_short |
Global, regional, and national burden of meningitis and its aetiologies, 1990 2019: a systematic analysis for the Global Burden of Disease Study 2019 |
| title_full |
Global, regional, and national burden of meningitis and its aetiologies, 1990 2019: a systematic analysis for the Global Burden of Disease Study 2019 |
| title_fullStr |
Global, regional, and national burden of meningitis and its aetiologies, 1990 2019: a systematic analysis for the Global Burden of Disease Study 2019 |
| title_full_unstemmed |
Global, regional, and national burden of meningitis and its aetiologies, 1990 2019: a systematic analysis for the Global Burden of Disease Study 2019 |
| title_sort |
Global, regional, and national burden of meningitis and its aetiologies, 1990 2019: a systematic analysis for the Global Burden of Disease Study 2019 |
| author |
Wunrow, Han Yong |
| author_facet |
Wunrow, Han Yong Bender, Rose G Vongpradith, Avina Sirota, Sarah Brooke Swetschinski, Lucien R Novotney, Amanda Gray, Authia P Perdigão, João GBD 2019 Meningitis Antimicrobial Resistance Collaborators |
| author_role |
author |
| author2 |
Bender, Rose G Vongpradith, Avina Sirota, Sarah Brooke Swetschinski, Lucien R Novotney, Amanda Gray, Authia P Perdigão, João GBD 2019 Meningitis Antimicrobial Resistance Collaborators |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Wunrow, Han Yong Bender, Rose G Vongpradith, Avina Sirota, Sarah Brooke Swetschinski, Lucien R Novotney, Amanda Gray, Authia P Perdigão, João GBD 2019 Meningitis Antimicrobial Resistance Collaborators |
| description |
Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-08 2023-12-29T12:16:49Z 2023-08-01T00:00:00Z 2024-01-19T14:54:46Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10451/61982 |
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http://hdl.handle.net/10451/61982 |
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eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Wunrow HY, Bender RG, Vongpradith A, Sirota SB, Swetschinski LR, Novotney A, et al. Global, regional, and national burden of meningitis and its aetiologies, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Neurology [Internet]. agosto de 2023;22(8):685–711. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S1474442223001953 1474-4422 cv-prod-3440107 10.1016/s1474-4422(23)00195-3 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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