Effects of irradiated glucose solutions on DMBA-induced tumors in rats.
Autor(a) principal: | |
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Data de Publicação: | 1981 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3881 |
Resumo: | This is a study of the effects of irradiated glucose-saline solutions (60Co, 105 R at a dose rate of 1.7 X 106 R/h) on tumors induced by the intravenous injection of dimethylbenzanthracene (DMBA) in female Sprague-Dawley rats. Each animal received 10 cc intraperitoneal injections of the irradiated solution spaced over 17 days. As a control two groups of tumor bearing animals were used: one received irradiated isotonic saline solution, and the other unirradiated glucose-saline solution. It could be concluded that those animals which received the irradiated glucose-saline solution experienced retardation of the tumor disease both during and after the treatment period relative to the other groups under study. The results suggest that radiolysis of hexoses can give rise to a carcinostatic compound relatively non-toxic toward non-dividing cells. |
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Effects of irradiated glucose solutions on DMBA-induced tumors in rats.This is a study of the effects of irradiated glucose-saline solutions (60Co, 105 R at a dose rate of 1.7 X 106 R/h) on tumors induced by the intravenous injection of dimethylbenzanthracene (DMBA) in female Sprague-Dawley rats. Each animal received 10 cc intraperitoneal injections of the irradiated solution spaced over 17 days. As a control two groups of tumor bearing animals were used: one received irradiated isotonic saline solution, and the other unirradiated glucose-saline solution. It could be concluded that those animals which received the irradiated glucose-saline solution experienced retardation of the tumor disease both during and after the treatment period relative to the other groups under study. The results suggest that radiolysis of hexoses can give rise to a carcinostatic compound relatively non-toxic toward non-dividing cells.Ordem dos Médicos1981-04-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3881oai:ojs.www.actamedicaportuguesa.com:article/3881Acta Médica Portuguesa; Vol. 3 No. 2 (1981): Março-Abril; 125-132Acta Médica Portuguesa; Vol. 3 N.º 2 (1981): Março-Abril; 125-1321646-07580870-399Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3881https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3881/3139Baptista, António M.Roppel, Richard M.info:eu-repo/semantics/openAccess2022-12-20T11:03:01Zoai:ojs.www.actamedicaportuguesa.com:article/3881Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:18:37.079079Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Effects of irradiated glucose solutions on DMBA-induced tumors in rats. |
title |
Effects of irradiated glucose solutions on DMBA-induced tumors in rats. |
spellingShingle |
Effects of irradiated glucose solutions on DMBA-induced tumors in rats. Baptista, António M. |
title_short |
Effects of irradiated glucose solutions on DMBA-induced tumors in rats. |
title_full |
Effects of irradiated glucose solutions on DMBA-induced tumors in rats. |
title_fullStr |
Effects of irradiated glucose solutions on DMBA-induced tumors in rats. |
title_full_unstemmed |
Effects of irradiated glucose solutions on DMBA-induced tumors in rats. |
title_sort |
Effects of irradiated glucose solutions on DMBA-induced tumors in rats. |
author |
Baptista, António M. |
author_facet |
Baptista, António M. Roppel, Richard M. |
author_role |
author |
author2 |
Roppel, Richard M. |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Baptista, António M. Roppel, Richard M. |
description |
This is a study of the effects of irradiated glucose-saline solutions (60Co, 105 R at a dose rate of 1.7 X 106 R/h) on tumors induced by the intravenous injection of dimethylbenzanthracene (DMBA) in female Sprague-Dawley rats. Each animal received 10 cc intraperitoneal injections of the irradiated solution spaced over 17 days. As a control two groups of tumor bearing animals were used: one received irradiated isotonic saline solution, and the other unirradiated glucose-saline solution. It could be concluded that those animals which received the irradiated glucose-saline solution experienced retardation of the tumor disease both during and after the treatment period relative to the other groups under study. The results suggest that radiolysis of hexoses can give rise to a carcinostatic compound relatively non-toxic toward non-dividing cells. |
publishDate |
1981 |
dc.date.none.fl_str_mv |
1981-04-30 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3881 oai:ojs.www.actamedicaportuguesa.com:article/3881 |
url |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3881 |
identifier_str_mv |
oai:ojs.www.actamedicaportuguesa.com:article/3881 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3881 https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3881/3139 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Ordem dos Médicos |
publisher.none.fl_str_mv |
Ordem dos Médicos |
dc.source.none.fl_str_mv |
Acta Médica Portuguesa; Vol. 3 No. 2 (1981): Março-Abril; 125-132 Acta Médica Portuguesa; Vol. 3 N.º 2 (1981): Março-Abril; 125-132 1646-0758 0870-399X reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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