Benign and malignant mammary tumors induced by DMBA in female Wistar rats

Detalhes bibliográficos
Autor(a) principal: Dias, M
Data de Publicação: 1999
Outros Autores: Cabrita, S, Sousa, E, França, B, Patrício, J, Oliveira, CF
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.4/106
Resumo: This study pretends to characterize 7, 12-dimetylbenz[a]anthracene-induced benign and malignant tumors. One hundred and twenty female Wistar rats were randomly allocated to two groups: Control Group and Induction Group; IG animals were given a single dose of DMBA and killed 24 weeks after. Other tumors besides breast tumors were diagnosed, mainly tumors of the salivary glands and ovarian benign epithelial tumors. Incidence of breast disorders was about 60%. Macroscopic mammary tumors varied in dimension from 2 mm to 55 mm. Malignant breast tumors (n = 56) were essentially invasive ductal carcinomas (91.1%), G1 (92.2%), presenting histologic characteristics of good prognosis. Predominant benign breast disorders consisted of glandular (68.6%) and atypical (20%) hyperplasias reproducing histologic types of human breast diseases. Different individual susceptibility to DMBA apparently occurs; while some rats never developed neoplasias, others exhibited several tumors.
id RCAP_fc8476931659bf5552fec4619aa37a4a
oai_identifier_str oai:rihuc.huc.min-saude.pt:10400.4/106
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Benign and malignant mammary tumors induced by DMBA in female Wistar ratsFibroadenomaNeoplasias Mamárias ExperimentaisRatosThis study pretends to characterize 7, 12-dimetylbenz[a]anthracene-induced benign and malignant tumors. One hundred and twenty female Wistar rats were randomly allocated to two groups: Control Group and Induction Group; IG animals were given a single dose of DMBA and killed 24 weeks after. Other tumors besides breast tumors were diagnosed, mainly tumors of the salivary glands and ovarian benign epithelial tumors. Incidence of breast disorders was about 60%. Macroscopic mammary tumors varied in dimension from 2 mm to 55 mm. Malignant breast tumors (n = 56) were essentially invasive ductal carcinomas (91.1%), G1 (92.2%), presenting histologic characteristics of good prognosis. Predominant benign breast disorders consisted of glandular (68.6%) and atypical (20%) hyperplasias reproducing histologic types of human breast diseases. Different individual susceptibility to DMBA apparently occurs; while some rats never developed neoplasias, others exhibited several tumors.RIHUCDias, MCabrita, SSousa, EFrança, BPatrício, JOliveira, CF2008-11-21T16:21:15Z19991999-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/106engEur J Gynaecol Oncol. 1999;20(4):285-8info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:21:15Zoai:rihuc.huc.min-saude.pt:10400.4/106Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:02:59.190074Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Benign and malignant mammary tumors induced by DMBA in female Wistar rats
title Benign and malignant mammary tumors induced by DMBA in female Wistar rats
spellingShingle Benign and malignant mammary tumors induced by DMBA in female Wistar rats
Dias, M
Fibroadenoma
Neoplasias Mamárias Experimentais
Ratos
title_short Benign and malignant mammary tumors induced by DMBA in female Wistar rats
title_full Benign and malignant mammary tumors induced by DMBA in female Wistar rats
title_fullStr Benign and malignant mammary tumors induced by DMBA in female Wistar rats
title_full_unstemmed Benign and malignant mammary tumors induced by DMBA in female Wistar rats
title_sort Benign and malignant mammary tumors induced by DMBA in female Wistar rats
author Dias, M
author_facet Dias, M
Cabrita, S
Sousa, E
França, B
Patrício, J
Oliveira, CF
author_role author
author2 Cabrita, S
Sousa, E
França, B
Patrício, J
Oliveira, CF
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv RIHUC
dc.contributor.author.fl_str_mv Dias, M
Cabrita, S
Sousa, E
França, B
Patrício, J
Oliveira, CF
dc.subject.por.fl_str_mv Fibroadenoma
Neoplasias Mamárias Experimentais
Ratos
topic Fibroadenoma
Neoplasias Mamárias Experimentais
Ratos
description This study pretends to characterize 7, 12-dimetylbenz[a]anthracene-induced benign and malignant tumors. One hundred and twenty female Wistar rats were randomly allocated to two groups: Control Group and Induction Group; IG animals were given a single dose of DMBA and killed 24 weeks after. Other tumors besides breast tumors were diagnosed, mainly tumors of the salivary glands and ovarian benign epithelial tumors. Incidence of breast disorders was about 60%. Macroscopic mammary tumors varied in dimension from 2 mm to 55 mm. Malignant breast tumors (n = 56) were essentially invasive ductal carcinomas (91.1%), G1 (92.2%), presenting histologic characteristics of good prognosis. Predominant benign breast disorders consisted of glandular (68.6%) and atypical (20%) hyperplasias reproducing histologic types of human breast diseases. Different individual susceptibility to DMBA apparently occurs; while some rats never developed neoplasias, others exhibited several tumors.
publishDate 1999
dc.date.none.fl_str_mv 1999
1999-01-01T00:00:00Z
2008-11-21T16:21:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.4/106
url http://hdl.handle.net/10400.4/106
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eur J Gynaecol Oncol. 1999;20(4):285-8
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799131694928756737

Registros relacionados