Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours

Detalhes bibliográficos
Autor(a) principal: Yang, Yang
Data de Publicação: 2018
Outros Autores: Qiu, Xiaofeng, Sun, Yi, Wang, Yifeng, Wang, Jine, Li, Yulin, Liu, Changsheng
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.13/5345
Resumo: Cell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(D,L-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane. In order to modify the hydrophobicity of the membrane (a limiting factor for its biomedical application), an amphiphilic monomethoxyl poly(ethylene glycol)-b-poly(D,L-lactide) (PEG-PDLLA) was selected to improve its surface hydrophilicity through a simple self-assembly approach. It was found that the contact angles of the modified membrane can be well controlled by variation of PEG-PDLLA concentrations. In vitro cell biological study indicates that optimized cell adhesion can be achieved on the modified membrane with a contact angle of around 50° via its self-assembly with an ethanol/water solution of PEG-PDLA (35 mg ml−1). The surface modification of the membrane also changed its biodegradation property in the process of its incubation period up to 240 days. The surface modification method may afford an effective way for adjustment of the surface (interface) of membrane (scaffolds) of different biomaterials, beyond polylactide.
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spelling Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behavioursRing opening polymerizationPoly(D,L-lactide) membraneAmphiphilic poly(ethylene glycol)-b-poly(D,L-lactide)Surface hydrophilicitybiodegradationCell behaviours.Faculdade de Ciências Exatas e da EngenhariaCell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(D,L-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane. In order to modify the hydrophobicity of the membrane (a limiting factor for its biomedical application), an amphiphilic monomethoxyl poly(ethylene glycol)-b-poly(D,L-lactide) (PEG-PDLLA) was selected to improve its surface hydrophilicity through a simple self-assembly approach. It was found that the contact angles of the modified membrane can be well controlled by variation of PEG-PDLLA concentrations. In vitro cell biological study indicates that optimized cell adhesion can be achieved on the modified membrane with a contact angle of around 50° via its self-assembly with an ethanol/water solution of PEG-PDLA (35 mg ml−1). The surface modification of the membrane also changed its biodegradation property in the process of its incubation period up to 240 days. The surface modification method may afford an effective way for adjustment of the surface (interface) of membrane (scaffolds) of different biomaterials, beyond polylactide.The Royal SocietyDigitUMaYang, YangQiu, XiaofengSun, YiWang, YifengWang, JineLi, YulinLiu, Changsheng2023-11-03T14:42:41Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.13/5345engYang, Y., Qiu, X., Sun, Y., Wang, Y., Wang, J., Li, Y., & Liu, C. (2018). Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours. Royal Society Open Science, 5(1), 170868.10.1098/rsos.170868info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-05T03:31:32Zoai:digituma.uma.pt:10400.13/5345Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:26:49.498868Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours
title Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours
spellingShingle Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours
Yang, Yang
Ring opening polymerization
Poly(D,L-lactide) membrane
Amphiphilic poly(ethylene glycol)-b-poly(D,L-lactide)
Surface hydrophilicity
biodegradation
Cell behaviours
.
Faculdade de Ciências Exatas e da Engenharia
title_short Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours
title_full Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours
title_fullStr Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours
title_full_unstemmed Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours
title_sort Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours
author Yang, Yang
author_facet Yang, Yang
Qiu, Xiaofeng
Sun, Yi
Wang, Yifeng
Wang, Jine
Li, Yulin
Liu, Changsheng
author_role author
author2 Qiu, Xiaofeng
Sun, Yi
Wang, Yifeng
Wang, Jine
Li, Yulin
Liu, Changsheng
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv DigitUMa
dc.contributor.author.fl_str_mv Yang, Yang
Qiu, Xiaofeng
Sun, Yi
Wang, Yifeng
Wang, Jine
Li, Yulin
Liu, Changsheng
dc.subject.por.fl_str_mv Ring opening polymerization
Poly(D,L-lactide) membrane
Amphiphilic poly(ethylene glycol)-b-poly(D,L-lactide)
Surface hydrophilicity
biodegradation
Cell behaviours
.
Faculdade de Ciências Exatas e da Engenharia
topic Ring opening polymerization
Poly(D,L-lactide) membrane
Amphiphilic poly(ethylene glycol)-b-poly(D,L-lactide)
Surface hydrophilicity
biodegradation
Cell behaviours
.
Faculdade de Ciências Exatas e da Engenharia
description Cell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(D,L-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane. In order to modify the hydrophobicity of the membrane (a limiting factor for its biomedical application), an amphiphilic monomethoxyl poly(ethylene glycol)-b-poly(D,L-lactide) (PEG-PDLLA) was selected to improve its surface hydrophilicity through a simple self-assembly approach. It was found that the contact angles of the modified membrane can be well controlled by variation of PEG-PDLLA concentrations. In vitro cell biological study indicates that optimized cell adhesion can be achieved on the modified membrane with a contact angle of around 50° via its self-assembly with an ethanol/water solution of PEG-PDLA (35 mg ml−1). The surface modification of the membrane also changed its biodegradation property in the process of its incubation period up to 240 days. The surface modification method may afford an effective way for adjustment of the surface (interface) of membrane (scaffolds) of different biomaterials, beyond polylactide.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2023-11-03T14:42:41Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.13/5345
url http://hdl.handle.net/10400.13/5345
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Yang, Y., Qiu, X., Sun, Y., Wang, Y., Wang, J., Li, Y., & Liu, C. (2018). Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours. Royal Society Open Science, 5(1), 170868.
10.1098/rsos.170868
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv The Royal Society
publisher.none.fl_str_mv The Royal Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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