Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.13/5345 |
Resumo: | Cell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(D,L-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane. In order to modify the hydrophobicity of the membrane (a limiting factor for its biomedical application), an amphiphilic monomethoxyl poly(ethylene glycol)-b-poly(D,L-lactide) (PEG-PDLLA) was selected to improve its surface hydrophilicity through a simple self-assembly approach. It was found that the contact angles of the modified membrane can be well controlled by variation of PEG-PDLLA concentrations. In vitro cell biological study indicates that optimized cell adhesion can be achieved on the modified membrane with a contact angle of around 50° via its self-assembly with an ethanol/water solution of PEG-PDLA (35 mg ml−1). The surface modification of the membrane also changed its biodegradation property in the process of its incubation period up to 240 days. The surface modification method may afford an effective way for adjustment of the surface (interface) of membrane (scaffolds) of different biomaterials, beyond polylactide. |
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Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behavioursRing opening polymerizationPoly(D,L-lactide) membraneAmphiphilic poly(ethylene glycol)-b-poly(D,L-lactide)Surface hydrophilicitybiodegradationCell behaviours.Faculdade de Ciências Exatas e da EngenhariaCell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(D,L-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane. In order to modify the hydrophobicity of the membrane (a limiting factor for its biomedical application), an amphiphilic monomethoxyl poly(ethylene glycol)-b-poly(D,L-lactide) (PEG-PDLLA) was selected to improve its surface hydrophilicity through a simple self-assembly approach. It was found that the contact angles of the modified membrane can be well controlled by variation of PEG-PDLLA concentrations. In vitro cell biological study indicates that optimized cell adhesion can be achieved on the modified membrane with a contact angle of around 50° via its self-assembly with an ethanol/water solution of PEG-PDLA (35 mg ml−1). The surface modification of the membrane also changed its biodegradation property in the process of its incubation period up to 240 days. The surface modification method may afford an effective way for adjustment of the surface (interface) of membrane (scaffolds) of different biomaterials, beyond polylactide.The Royal SocietyDigitUMaYang, YangQiu, XiaofengSun, YiWang, YifengWang, JineLi, YulinLiu, Changsheng2023-11-03T14:42:41Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.13/5345engYang, Y., Qiu, X., Sun, Y., Wang, Y., Wang, J., Li, Y., & Liu, C. (2018). Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours. Royal Society Open Science, 5(1), 170868.10.1098/rsos.170868info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-05T03:31:32Zoai:digituma.uma.pt:10400.13/5345Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:26:49.498868Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours |
title |
Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours |
spellingShingle |
Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours Yang, Yang Ring opening polymerization Poly(D,L-lactide) membrane Amphiphilic poly(ethylene glycol)-b-poly(D,L-lactide) Surface hydrophilicity biodegradation Cell behaviours . Faculdade de Ciências Exatas e da Engenharia |
title_short |
Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours |
title_full |
Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours |
title_fullStr |
Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours |
title_full_unstemmed |
Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours |
title_sort |
Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours |
author |
Yang, Yang |
author_facet |
Yang, Yang Qiu, Xiaofeng Sun, Yi Wang, Yifeng Wang, Jine Li, Yulin Liu, Changsheng |
author_role |
author |
author2 |
Qiu, Xiaofeng Sun, Yi Wang, Yifeng Wang, Jine Li, Yulin Liu, Changsheng |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
DigitUMa |
dc.contributor.author.fl_str_mv |
Yang, Yang Qiu, Xiaofeng Sun, Yi Wang, Yifeng Wang, Jine Li, Yulin Liu, Changsheng |
dc.subject.por.fl_str_mv |
Ring opening polymerization Poly(D,L-lactide) membrane Amphiphilic poly(ethylene glycol)-b-poly(D,L-lactide) Surface hydrophilicity biodegradation Cell behaviours . Faculdade de Ciências Exatas e da Engenharia |
topic |
Ring opening polymerization Poly(D,L-lactide) membrane Amphiphilic poly(ethylene glycol)-b-poly(D,L-lactide) Surface hydrophilicity biodegradation Cell behaviours . Faculdade de Ciências Exatas e da Engenharia |
description |
Cell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(D,L-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane. In order to modify the hydrophobicity of the membrane (a limiting factor for its biomedical application), an amphiphilic monomethoxyl poly(ethylene glycol)-b-poly(D,L-lactide) (PEG-PDLLA) was selected to improve its surface hydrophilicity through a simple self-assembly approach. It was found that the contact angles of the modified membrane can be well controlled by variation of PEG-PDLLA concentrations. In vitro cell biological study indicates that optimized cell adhesion can be achieved on the modified membrane with a contact angle of around 50° via its self-assembly with an ethanol/water solution of PEG-PDLA (35 mg ml−1). The surface modification of the membrane also changed its biodegradation property in the process of its incubation period up to 240 days. The surface modification method may afford an effective way for adjustment of the surface (interface) of membrane (scaffolds) of different biomaterials, beyond polylactide. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z 2023-11-03T14:42:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.13/5345 |
url |
http://hdl.handle.net/10400.13/5345 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Yang, Y., Qiu, X., Sun, Y., Wang, Y., Wang, J., Li, Y., & Liu, C. (2018). Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours. Royal Society Open Science, 5(1), 170868. 10.1098/rsos.170868 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
The Royal Society |
publisher.none.fl_str_mv |
The Royal Society |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134150196723712 |