Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media

Detalhes bibliográficos
Autor(a) principal: Moro, Artur J.
Data de Publicação: 2020
Outros Autores: Avó, João, Malfois, Marc, Zaccaria, Francesco, Guerra, Célia Fonseca, Caparrós, Francisco J., Rodríguez, Laura, Lima, João Carlos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/91998
Resumo: FCT/MCTES (UID/QUI/50006/2019). AEI/FEDER, UE Projects CTQ2016-76120-P. FRH/BPD/120599/2016
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spelling Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous mediaFCT/MCTES (UID/QUI/50006/2019). AEI/FEDER, UE Projects CTQ2016-76120-P. FRH/BPD/120599/2016A new organometallic alkynyl–gold(I) complex capable of exhibiting aggregation induced emission was designed and synthesized. The linear complex structure possesses a central Au(I) atom, bearing two axial ligands: (1) 1,3,5-triaza-7-phosphaadamantane and (2) 2-acetamido-7-ethynyl-1,8-naphthyridine. While the former accounts for its partial solubility in an aqueous environment, the latter acts as a receptor unit for binding guanosine nucleotides and derivatives via multiple hydrogen bonding interactions. At high concentrations, aggregation of the complex was observed by the formation of new absorption (λmax ∼ 400 nm) and emission bands (550–700 nm). Formation of aggregates of ca. 60 nm diameter was confirmed by Small Angle X-ray Scattering (SAXS). Disruption of the aggregates in the presence of guanosine derivatives resulted in a ratiometric signal with apparent association constants in the order of 105 M−1 and high sensitivity (around 63% signal change) which are, to the best of our knowledge, in line with the highest values recorded for nucleotide sensors based on hydrogen bonding and capable of working in water. Computational studies indicate the presence of additional hydrogen bonding interactions that account for the strong binding of the Au(I) complex to phosphorylated guanosine nucleotides.DQ - Departamento de QuímicaLAQV@REQUIMTERUNMoro, Artur J.Avó, JoãoMalfois, MarcZaccaria, FrancescoGuerra, Célia FonsecaCaparrós, Francisco J.Rodríguez, LauraLima, João Carlos2022-03-31T00:31:40Z2020-01-072020-01-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/91998eng1477-9226PURE: 15683608https://doi.org/10.1039/C9DT04162Ainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:40:57Zoai:run.unl.pt:10362/91998Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:37:26.642102Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media
title Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media
spellingShingle Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media
Moro, Artur J.
title_short Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media
title_full Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media
title_fullStr Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media
title_full_unstemmed Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media
title_sort Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media
author Moro, Artur J.
author_facet Moro, Artur J.
Avó, João
Malfois, Marc
Zaccaria, Francesco
Guerra, Célia Fonseca
Caparrós, Francisco J.
Rodríguez, Laura
Lima, João Carlos
author_role author
author2 Avó, João
Malfois, Marc
Zaccaria, Francesco
Guerra, Célia Fonseca
Caparrós, Francisco J.
Rodríguez, Laura
Lima, João Carlos
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Moro, Artur J.
Avó, João
Malfois, Marc
Zaccaria, Francesco
Guerra, Célia Fonseca
Caparrós, Francisco J.
Rodríguez, Laura
Lima, João Carlos
description FCT/MCTES (UID/QUI/50006/2019). AEI/FEDER, UE Projects CTQ2016-76120-P. FRH/BPD/120599/2016
publishDate 2020
dc.date.none.fl_str_mv 2020-01-07
2020-01-07T00:00:00Z
2022-03-31T00:31:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/91998
url http://hdl.handle.net/10362/91998
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1477-9226
PURE: 15683608
https://doi.org/10.1039/C9DT04162A
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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