Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/91998 |
Resumo: | FCT/MCTES (UID/QUI/50006/2019). AEI/FEDER, UE Projects CTQ2016-76120-P. FRH/BPD/120599/2016 |
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oai:run.unl.pt:10362/91998 |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
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Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous mediaFCT/MCTES (UID/QUI/50006/2019). AEI/FEDER, UE Projects CTQ2016-76120-P. FRH/BPD/120599/2016A new organometallic alkynyl–gold(I) complex capable of exhibiting aggregation induced emission was designed and synthesized. The linear complex structure possesses a central Au(I) atom, bearing two axial ligands: (1) 1,3,5-triaza-7-phosphaadamantane and (2) 2-acetamido-7-ethynyl-1,8-naphthyridine. While the former accounts for its partial solubility in an aqueous environment, the latter acts as a receptor unit for binding guanosine nucleotides and derivatives via multiple hydrogen bonding interactions. At high concentrations, aggregation of the complex was observed by the formation of new absorption (λmax ∼ 400 nm) and emission bands (550–700 nm). Formation of aggregates of ca. 60 nm diameter was confirmed by Small Angle X-ray Scattering (SAXS). Disruption of the aggregates in the presence of guanosine derivatives resulted in a ratiometric signal with apparent association constants in the order of 105 M−1 and high sensitivity (around 63% signal change) which are, to the best of our knowledge, in line with the highest values recorded for nucleotide sensors based on hydrogen bonding and capable of working in water. Computational studies indicate the presence of additional hydrogen bonding interactions that account for the strong binding of the Au(I) complex to phosphorylated guanosine nucleotides.DQ - Departamento de QuímicaLAQV@REQUIMTERUNMoro, Artur J.Avó, JoãoMalfois, MarcZaccaria, FrancescoGuerra, Célia FonsecaCaparrós, Francisco J.Rodríguez, LauraLima, João Carlos2022-03-31T00:31:40Z2020-01-072020-01-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/91998eng1477-9226PURE: 15683608https://doi.org/10.1039/C9DT04162Ainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:40:57Zoai:run.unl.pt:10362/91998Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:37:26.642102Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media |
title |
Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media |
spellingShingle |
Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media Moro, Artur J. |
title_short |
Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media |
title_full |
Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media |
title_fullStr |
Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media |
title_full_unstemmed |
Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media |
title_sort |
Aggregation induced emission of a new naphthyridine-ethynyl–gold(i) complex as a potential tool for sensing guanosine nucleotides in aqueous media |
author |
Moro, Artur J. |
author_facet |
Moro, Artur J. Avó, João Malfois, Marc Zaccaria, Francesco Guerra, Célia Fonseca Caparrós, Francisco J. Rodríguez, Laura Lima, João Carlos |
author_role |
author |
author2 |
Avó, João Malfois, Marc Zaccaria, Francesco Guerra, Célia Fonseca Caparrós, Francisco J. Rodríguez, Laura Lima, João Carlos |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
DQ - Departamento de Química LAQV@REQUIMTE RUN |
dc.contributor.author.fl_str_mv |
Moro, Artur J. Avó, João Malfois, Marc Zaccaria, Francesco Guerra, Célia Fonseca Caparrós, Francisco J. Rodríguez, Laura Lima, João Carlos |
description |
FCT/MCTES (UID/QUI/50006/2019). AEI/FEDER, UE Projects CTQ2016-76120-P. FRH/BPD/120599/2016 |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-07 2020-01-07T00:00:00Z 2022-03-31T00:31:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/91998 |
url |
http://hdl.handle.net/10362/91998 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1477-9226 PURE: 15683608 https://doi.org/10.1039/C9DT04162A |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
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1799137991180943360 |