Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal
| Autor(a) principal: | |
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| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/8960 |
Resumo: | Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579057/ |
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Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in PortugalMpoxMpox VirusMonkeypoxMonkeypox VirusCluster AnalysisDisease OutbreaksSexual and Gender MinoritiesDoenças InfeciosasInfecções EmergentesPortugalFree PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579057/Pathogen genome sequencing during epidemics enhances our ability to identify and understand suspected clusters and investigate their relationships. Here, we combine genomic and epidemiological data of the 2022 mpox outbreak to better understand early viral spread, diversification and transmission dynamics. By sequencing 52% of the confirmed cases in Portugal, we identified the mpox virus sublineages with the highest impact on case numbers and fitted them into a global context, finding evidence that several international sublineages probably emerged or spread early in Portugal. We estimated a 62% infection reporting rate and that 1.3% of the population of men who have sex with men in Portugal were infected. We infer the critical role played by sexual networks and superspreader gatherings, such as sauna attendance, in the dissemination of mpox virus. Overall, our findings highlight genomic epidemiology as a tool for the real-time monitoring and control of mpox epidemics, and can guide future vaccine policy in a highly susceptible population.The acquisition of equipment associated with whole-genome sequencing used in this study (including the Illumina NextSeq 2000) was funded by the HERA (Human and Environmental Risk Assessment) project (Grant/2021/PHF/23776), supported by the European Commission through the European Centre for Disease Prevention and Control (ECDC), and partially funded by the GenomePT project (POCI-01- 0145-FEDER-022184), supported by COMPETE 2020 (Operational Programme for Competitiveness and Internationalisation (POCI)), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020) under the PORTUGAL 2020 Partnership Agreement through the European Regional Development Fund (ERDF), and by the Portuguese Science and Technology Foundation (FCT). This study was also supported by the ERINHA-Advance project (funded by the European Union’s Horizon 2020 Research & Innovation program, grant agreement no. 824061) and benefited from co-funding from the European Union’s Horizon 2020 Research and Innovation programme under grant agreement no. 773830 (One Health European Joint Programme), in particular by the co-funding of the post-doctoral fellowships of J.S.D. and V.M. and the development of INSaFLU. We also thank M. Pinheiro (iBiMED at the Universidade de Aveiro) for his continuous support in updating the INSaFLU platform and the Infraestrutura Nacional de Computação Distribuída (INCD) for providing computational resources for testing it. INCD was funded by the FCT and FEDER under the project 22153-01/SAICT/2016. M.P.D. is funded by the Gates Cambridge Scholarship (no. OPP1144).Nature ResearchRepositório Científico do Instituto Nacional de SaúdeBorges, VítorDuque, Mariana PerezMartins, João VieiraVasconcelos, PaulaFerreira, RitaSobral, DanielPelerito, Anade Carvalho, Isabel LopesNúncio, Maria SofiaBorrego, Maria JoséRoemer, CorneliusNeher, Richard A.O’Driscoll, MeganRocha, RaquelLopo, SílviaNeves, RaquelPalminha, PaulaCoelho, LuísNunes, AlexandraIsidro, JoanaPinto, MiguelSantos, João DouradoMixão, VerónicaSantos, DanielaDuarte, SilviaVieira, LuísMartins, FátimaMachado, JorgeVeríssimo, Vítor CabralGrau, BertaPeralta-Santos, AndréNeves, JoséCaldeira, MargaridaPestana, MafaldaFernandes, CândidaCaria, JoãoPinto, RaquelPóvoas, DianaMaltez, FernandoSá, Ana IsabelSalvador, Mafalda BritoTeófilo, EugénioRocha, MiguelMoneti, VirginiaDuque, Luis Miguele Silva, Francisco FerreiraBaptista, TeresaVasconcelos, JoanaCasanova, SaraMansinho, KamalAlves, João VazAlves, JoãoSilva, AntónioAlpalhão, MiguelBrazão, CláudiaSousa, DiogoFilipe, PauloPacheco, PatríciaPeruzzu, Francescade Jesus, Rita PatrocínioFerreira, LuísMendez, JosefinaJordão, SofiaDuarte, FredericoGonçalves, Maria JoãoPena, EduardaSilva, Claúdio NunesGuimarães, André RodriguesTavares, MargaridaFreitas, GraçaCordeiro, RitaGomes, João Paulo2024-01-24T12:32:32Z2023-09-112023-09-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8960engNat Med. 2023 Oct;29(10):2509-2517. doi: 10.1038/s41591-023-02542-x. Epub 2023 Sep 111078-895610.1038/s41591-023-02542-xinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-27T01:31:44Zoai:repositorio.insa.pt:10400.18/8960Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:57:59.285167Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| title |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| spellingShingle |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal Borges, Vítor Mpox Mpox Virus Monkeypox Monkeypox Virus Cluster Analysis Disease Outbreaks Sexual and Gender Minorities Doenças Infeciosas Infecções Emergentes Portugal |
| title_short |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| title_full |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| title_fullStr |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| title_full_unstemmed |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| title_sort |
Viral genetic clustering and transmission dynamics of the 2022 mpox outbreak in Portugal |
| author |
Borges, Vítor |
| author_facet |
Borges, Vítor Duque, Mariana Perez Martins, João Vieira Vasconcelos, Paula Ferreira, Rita Sobral, Daniel Pelerito, Ana de Carvalho, Isabel Lopes Núncio, Maria Sofia Borrego, Maria José Roemer, Cornelius Neher, Richard A. O’Driscoll, Megan Rocha, Raquel Lopo, Sílvia Neves, Raquel Palminha, Paula Coelho, Luís Nunes, Alexandra Isidro, Joana Pinto, Miguel Santos, João Dourado Mixão, Verónica Santos, Daniela Duarte, Silvia Vieira, Luís Martins, Fátima Machado, Jorge Veríssimo, Vítor Cabral Grau, Berta Peralta-Santos, André Neves, José Caldeira, Margarida Pestana, Mafalda Fernandes, Cândida Caria, João Pinto, Raquel Póvoas, Diana Maltez, Fernando Sá, Ana Isabel Salvador, Mafalda Brito Teófilo, Eugénio Rocha, Miguel Moneti, Virginia Duque, Luis Miguel e Silva, Francisco Ferreira Baptista, Teresa Vasconcelos, Joana Casanova, Sara Mansinho, Kamal Alves, João Vaz Alves, João Silva, António Alpalhão, Miguel Brazão, Cláudia Sousa, Diogo Filipe, Paulo Pacheco, Patrícia Peruzzu, Francesca de Jesus, Rita Patrocínio Ferreira, Luís Mendez, Josefina Jordão, Sofia Duarte, Frederico Gonçalves, Maria João Pena, Eduarda Silva, Claúdio Nunes Guimarães, André Rodrigues Tavares, Margarida Freitas, Graça Cordeiro, Rita Gomes, João Paulo |
| author_role |
author |
| author2 |
Duque, Mariana Perez Martins, João Vieira Vasconcelos, Paula Ferreira, Rita Sobral, Daniel Pelerito, Ana de Carvalho, Isabel Lopes Núncio, Maria Sofia Borrego, Maria José Roemer, Cornelius Neher, Richard A. O’Driscoll, Megan Rocha, Raquel Lopo, Sílvia Neves, Raquel Palminha, Paula Coelho, Luís Nunes, Alexandra Isidro, Joana Pinto, Miguel Santos, João Dourado Mixão, Verónica Santos, Daniela Duarte, Silvia Vieira, Luís Martins, Fátima Machado, Jorge Veríssimo, Vítor Cabral Grau, Berta Peralta-Santos, André Neves, José Caldeira, Margarida Pestana, Mafalda Fernandes, Cândida Caria, João Pinto, Raquel Póvoas, Diana Maltez, Fernando Sá, Ana Isabel Salvador, Mafalda Brito Teófilo, Eugénio Rocha, Miguel Moneti, Virginia Duque, Luis Miguel e Silva, Francisco Ferreira Baptista, Teresa Vasconcelos, Joana Casanova, Sara Mansinho, Kamal Alves, João Vaz Alves, João Silva, António Alpalhão, Miguel Brazão, Cláudia Sousa, Diogo Filipe, Paulo Pacheco, Patrícia Peruzzu, Francesca de Jesus, Rita Patrocínio Ferreira, Luís Mendez, Josefina Jordão, Sofia Duarte, Frederico Gonçalves, Maria João Pena, Eduarda Silva, Claúdio Nunes Guimarães, André Rodrigues Tavares, Margarida Freitas, Graça Cordeiro, Rita Gomes, João Paulo |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Borges, Vítor Duque, Mariana Perez Martins, João Vieira Vasconcelos, Paula Ferreira, Rita Sobral, Daniel Pelerito, Ana de Carvalho, Isabel Lopes Núncio, Maria Sofia Borrego, Maria José Roemer, Cornelius Neher, Richard A. O’Driscoll, Megan Rocha, Raquel Lopo, Sílvia Neves, Raquel Palminha, Paula Coelho, Luís Nunes, Alexandra Isidro, Joana Pinto, Miguel Santos, João Dourado Mixão, Verónica Santos, Daniela Duarte, Silvia Vieira, Luís Martins, Fátima Machado, Jorge Veríssimo, Vítor Cabral Grau, Berta Peralta-Santos, André Neves, José Caldeira, Margarida Pestana, Mafalda Fernandes, Cândida Caria, João Pinto, Raquel Póvoas, Diana Maltez, Fernando Sá, Ana Isabel Salvador, Mafalda Brito Teófilo, Eugénio Rocha, Miguel Moneti, Virginia Duque, Luis Miguel e Silva, Francisco Ferreira Baptista, Teresa Vasconcelos, Joana Casanova, Sara Mansinho, Kamal Alves, João Vaz Alves, João Silva, António Alpalhão, Miguel Brazão, Cláudia Sousa, Diogo Filipe, Paulo Pacheco, Patrícia Peruzzu, Francesca de Jesus, Rita Patrocínio Ferreira, Luís Mendez, Josefina Jordão, Sofia Duarte, Frederico Gonçalves, Maria João Pena, Eduarda Silva, Claúdio Nunes Guimarães, André Rodrigues Tavares, Margarida Freitas, Graça Cordeiro, Rita Gomes, João Paulo |
| dc.subject.por.fl_str_mv |
Mpox Mpox Virus Monkeypox Monkeypox Virus Cluster Analysis Disease Outbreaks Sexual and Gender Minorities Doenças Infeciosas Infecções Emergentes Portugal |
| topic |
Mpox Mpox Virus Monkeypox Monkeypox Virus Cluster Analysis Disease Outbreaks Sexual and Gender Minorities Doenças Infeciosas Infecções Emergentes Portugal |
| description |
Free PMC article: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10579057/ |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-09-11 2023-09-11T00:00:00Z 2024-01-24T12:32:32Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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http://hdl.handle.net/10400.18/8960 |
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http://hdl.handle.net/10400.18/8960 |
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eng |
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eng |
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Nat Med. 2023 Oct;29(10):2509-2517. doi: 10.1038/s41591-023-02542-x. Epub 2023 Sep 11 1078-8956 10.1038/s41591-023-02542-x |
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openAccess |
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application/pdf |
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Nature Research |
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Nature Research |
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