CONTACT URTICARIA INDUCED BY DRUGS

• Autor(a) principal: Gameiro, Ana
• Data de Publicação: 2016
• Outros Autores: Gouveia, Miguel, Ramos, Leonor, Gonçalo, Margarida
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://doi.org/10.29021/spdv.73.4.489
• topic: Anaphylaxis/chemically induced; Dermatitis; Contact; Allergic Contact; Drug Hypersensitivity; Urticaria/ chemically induced; Anafilaxia/induzida quimicamente; Dermatite Alérgica de Contacto; Dermatite de Contacto; Hipersensibilidade a Medicamentos; Urticária/induzida quimicamente

Contact dermatitis includes any inflammatory skin reaction due to direct or indirect skin contact with noxious agents. The main clinical expression is eczema and other delayed reactions, but immediate reactions, namely contact urticaria, can also occur. Contact urticaria has a broad range of clinical manifestations. The limited form is restricted to the area of contact between the allergen and the skin or mucosa, but more severe presentations include generalized urticaria lesions, angioedema and even anaphylaxis. All topical drugs can theoretically precipitate contact urticaria. The culprit may be either the active compound or the excipients, and the mechanisms of the immediate reactions can be both immune-mediated (IgE-dependent) and non-immune-mediated. The authors present an overview of the different drugs reported to induce contact urticaria, emphasizing the specific contexts of mucosal exposure and contact urticaria induced by drugs in occupational settings.