Evidence of DNA damage in humans inhabiting a volcanically active environment: a useful tool for biomonitoring

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Armindo
Data de Publicação: 2012
Outros Autores: Arruda, Mónica, Garcia, Patrícia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.3/1791
Resumo: Copyright © 2012 Elsevier Ltd. All rights reserved.
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spelling Evidence of DNA damage in humans inhabiting a volcanically active environment: a useful tool for biomonitoringBuccal Exfoliated CellsMicronucleiGenotoxicVolcanismCopyright © 2012 Elsevier Ltd. All rights reserved.The present study was designed to evaluate whether chronic exposure to a volcanically active environment might result in genotoxic and cytotoxic effects in human oral epithelial cells. A study group of 120 individuals inhabiting a volcanically active environment (exposed group; Furnas village) and a reference group of 122 individuals inhabiting a village without manifestations of volcanic activity (Santo António village) were examined in this study. Individuals from Furnas village inhabit a volcanically active environment marked by several degassing manifestations, including fumarolic fields, thermal and cold CO2 springs and soil diffuse degassing areas. For each individual, 1000 buccal epithelial cells were analyzed for the frequency of micronucleated cells (MNC) and the frequency of cells with other nuclear anomalies (ONA: pyknosis, karyolysis and karyorrhexis), by using the micronucleus assay. Information on life-style factors and an informed consent were obtained from each participant. The frequencies of MNC and of ONA per 1000 cells in the exposed group (4.3‰ and 23.5‰, respectively) were significantly higher than in the reference group (1.7‰ and 7.7‰, respectively). The risk of having a high frequency of MNC or ONA was 2.4 and 3.1-fold higher in exposed individuals compared to reference group. The analyzed confounding factors (age, gender, smoking status, alcohol consumption, and mouthwash use) did not show any significant association with the frequency of MNC or ONA. The higher risk of DNA damage in individuals inhabiting a volcanically active environment is for the first time clearly highlighted with this biomonitoring study. Given that MNC in oral epithelia are recognized as a predictive biomarker of cancer risk within a population of healthy subjects, these findings could contribute to explain the high incidence rates of lip, oral cavity and pharynx cancers previously referred for Furnas village inhabitants.ElsevierRepositório da Universidade dos AçoresRodrigues, ArmindoArruda, MónicaGarcia, Patrícia2013-04-09T14:15:53Z2012-08-172012-08-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/1791engRodrigues, A.S., Arruda, M.S.C. & Garcia, P.V. (2012). "Evidence of DNA damage in humans inhabiting a volcanically active environment: a useful tool for biomonitoring". «Environment International»: 49: 51–56. http://dx.doi.org/10.1016/j.envint.2012.08.008.0160-4120 (Print)info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:29:26Zoai:repositorio.uac.pt:10400.3/1791Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:24:30.922675Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evidence of DNA damage in humans inhabiting a volcanically active environment: a useful tool for biomonitoring
title Evidence of DNA damage in humans inhabiting a volcanically active environment: a useful tool for biomonitoring
spellingShingle Evidence of DNA damage in humans inhabiting a volcanically active environment: a useful tool for biomonitoring
Rodrigues, Armindo
Buccal Exfoliated Cells
Micronuclei
Genotoxic
Volcanism
title_short Evidence of DNA damage in humans inhabiting a volcanically active environment: a useful tool for biomonitoring
title_full Evidence of DNA damage in humans inhabiting a volcanically active environment: a useful tool for biomonitoring
title_fullStr Evidence of DNA damage in humans inhabiting a volcanically active environment: a useful tool for biomonitoring
title_full_unstemmed Evidence of DNA damage in humans inhabiting a volcanically active environment: a useful tool for biomonitoring
title_sort Evidence of DNA damage in humans inhabiting a volcanically active environment: a useful tool for biomonitoring
author Rodrigues, Armindo
author_facet Rodrigues, Armindo
Arruda, Mónica
Garcia, Patrícia
author_role author
author2 Arruda, Mónica
Garcia, Patrícia
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade dos Açores
dc.contributor.author.fl_str_mv Rodrigues, Armindo
Arruda, Mónica
Garcia, Patrícia
dc.subject.por.fl_str_mv Buccal Exfoliated Cells
Micronuclei
Genotoxic
Volcanism
topic Buccal Exfoliated Cells
Micronuclei
Genotoxic
Volcanism
description Copyright © 2012 Elsevier Ltd. All rights reserved.
publishDate 2012
dc.date.none.fl_str_mv 2012-08-17
2012-08-17T00:00:00Z
2013-04-09T14:15:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.3/1791
url http://hdl.handle.net/10400.3/1791
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rodrigues, A.S., Arruda, M.S.C. & Garcia, P.V. (2012). "Evidence of DNA damage in humans inhabiting a volcanically active environment: a useful tool for biomonitoring". «Environment International»: 49: 51–56. http://dx.doi.org/10.1016/j.envint.2012.08.008.
0160-4120 (Print)
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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