Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells

Detalhes bibliográficos
Autor(a) principal: Garcia, Patrícia
Data de Publicação: 2012
Outros Autores: Linhares, Diana P., Amaral, A. F. S., Rodrigues, Armindo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.3/1667
Resumo: Copyright © 2012 Elsevier B.V. All rights reserved.
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spelling Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cellsVOCsDNA DamageBio-MonitoringBuccal Exfoliated CellsMicronucleiOccupational ExposureCopyright © 2012 Elsevier B.V. All rights reserved.Thermoelectric power-plant workers are constantly exposed to high levels of potentially genotoxic gaseous substances, such as volatile organic compounds (VOCs) from the combustion of fuel oil or the processing of naphtha. The aim of the present study was to estimate the association between such occupational exposure and the frequency of micronucleated cells and cells with other nuclear anomalies. Buccal epithelial cells were collected from a total of 44 power-plant workers (exposed group) and 47 administrative workers (non-exposed group), and examined for the frequency of micronucleated cells (MNC) and of cells with other nuclear anomalies (ONA: pyknosis, karyolysis, and karyorrhexis) by means of the micronucleus assay. The frequencies of MNC and ONA per 1000 cells in the exposed group (1.8‰ and 82.4‰, respectively) were significantly higher than in the non-exposed group (0.2‰ and 58.3‰, respectively). The exposed group had a twelve-fold increase in risk for formation of MNC compared with non-exposed individuals (RR = 12.1; 95% CI, 5.0–29.2; P < 0.001). The confounding factors analyzed (age, smoking status, alcohol consumption, and mouthwash use) did not show any significant association with the frequency of MNC or ONA. The findings of this study show that workers from power plants exposed to VOCs have a significantly elevated risk for DNA damage. Therefore, bio-monitoring of DNA damage is recommended for this group of workers.ElsevierRepositório da Universidade dos AçoresGarcia, PatríciaLinhares, Diana P.Amaral, A. F. S.Rodrigues, Armindo2013-03-11T17:34:21Z2012-092012-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.3/1667engGarcia, P., Linhares, D., Amaral, A.F.S. &. Rodrigues, A. (2012). "Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells". «Mutation Research/Genetic Toxicology and Environmental Mutagenesis», 747(2): 197-201. http://dx.doi.org/10.1016/j.mrgentox.2012.05.008.1383-5718info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-12-20T14:29:26Zoai:repositorio.uac.pt:10400.3/1667Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:24:30.864270Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells
title Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells
spellingShingle Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells
Garcia, Patrícia
VOCs
DNA Damage
Bio-Monitoring
Buccal Exfoliated Cells
Micronuclei
Occupational Exposure
title_short Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells
title_full Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells
title_fullStr Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells
title_full_unstemmed Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells
title_sort Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells
author Garcia, Patrícia
author_facet Garcia, Patrícia
Linhares, Diana P.
Amaral, A. F. S.
Rodrigues, Armindo
author_role author
author2 Linhares, Diana P.
Amaral, A. F. S.
Rodrigues, Armindo
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade dos Açores
dc.contributor.author.fl_str_mv Garcia, Patrícia
Linhares, Diana P.
Amaral, A. F. S.
Rodrigues, Armindo
dc.subject.por.fl_str_mv VOCs
DNA Damage
Bio-Monitoring
Buccal Exfoliated Cells
Micronuclei
Occupational Exposure
topic VOCs
DNA Damage
Bio-Monitoring
Buccal Exfoliated Cells
Micronuclei
Occupational Exposure
description Copyright © 2012 Elsevier B.V. All rights reserved.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
2012-09-01T00:00:00Z
2013-03-11T17:34:21Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.3/1667
url http://hdl.handle.net/10400.3/1667
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Garcia, P., Linhares, D., Amaral, A.F.S. &. Rodrigues, A. (2012). "Exposure of thermoelectric power-plant workers to volatile organic compounds from fuel oil: Genotoxic and cytotoxic effects in buccal epithelial cells". «Mutation Research/Genetic Toxicology and Environmental Mutagenesis», 747(2): 197-201. http://dx.doi.org/10.1016/j.mrgentox.2012.05.008.
1383-5718
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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