Activity of phenolic compounds from plant origin against Candida species

Detalhes bibliográficos
Autor(a) principal: Martins, Natália
Data de Publicação: 2015
Outros Autores: Barros, Lillian, Henriques, Mariana, Silva, Sónia, Ferreira, Isabel C.F.R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/12427
Resumo: Candida albicans and other Candida species have been highly associated with several opportunistic fungal infections. Their ability to develop host infections is incited by different determinants, being virulence factors the most highlighted. Molecular targets of the antifungal drugs are crucial components for determination of yeast survival. Ergosterol, nucleic acids and glucan are the most studied molecular targets to destroy Candida species, being considered the basis of the development of new antifungal drugs. However, increasing levels of resistant Candida species to the current antifungal drugs have been observed, making ineffective those agents. Thus, other therapies more effective and safer than the current ones, are being studied, namely the use plant of extracts enriched in phenolic compounds. In this sense, this manuscript provide an historical perspective of the opportunistic fungal infections, molecular targets of the current anti-Candida drugs, as well as a general description of the active principles present in plants, focused on the antifungal potential of whole plant extracts and isolated phenolic compounds, against Candida species.
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spelling Activity of phenolic compounds from plant origin against Candida speciesPhytochemicalsPlant extractsPhenolic compoundsAntifungal activityCandida speciesCandida albicans and other Candida species have been highly associated with several opportunistic fungal infections. Their ability to develop host infections is incited by different determinants, being virulence factors the most highlighted. Molecular targets of the antifungal drugs are crucial components for determination of yeast survival. Ergosterol, nucleic acids and glucan are the most studied molecular targets to destroy Candida species, being considered the basis of the development of new antifungal drugs. However, increasing levels of resistant Candida species to the current antifungal drugs have been observed, making ineffective those agents. Thus, other therapies more effective and safer than the current ones, are being studied, namely the use plant of extracts enriched in phenolic compounds. In this sense, this manuscript provide an historical perspective of the opportunistic fungal infections, molecular targets of the current anti-Candida drugs, as well as a general description of the active principles present in plants, focused on the antifungal potential of whole plant extracts and isolated phenolic compounds, against Candida species.The authors are grateful to Foundation for Science and Technology (FCT, Portugal) for N. Martins grant (SFRH/BD/87658/2012), L. Barros researcher contract under “Programa Compromisso com Ciência – 2008” and financial support to the research centre CIMO (strategic project PEst-OE/AGR/UI0690/2011). This work was also supported by the Programa Operacional, Fatores de competitividade – COMPETE and by national funds through FCT – Fundação para a Ciência e a Tecnologia on the scope of the projects FCT PTDC/SAU-MIC/119069/2010, RECI/EBB-EBI/0179/2012 and PEst-OE/EQB/LA0023/2013. The authors thank the Project “BioHealth - Biotechnology and Bioengineering approaches to improve health quality", Ref. NORTE-07-0124-FEDER-000027, co-funded by the Programa Operacional Regional do Norte (ON.2 – O Novo Norte), QREN, FEDER.Biblioteca Digital do IPBMartins, NatáliaBarros, LillianHenriques, MarianaSilva, SóniaFerreira, Isabel C.F.R.2015-11-26T09:50:27Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10198/12427engMartins, Natália; Barros, Lillian; Henriques, Mariana; Silva, Sónia; Ferreira, Isabel C.F.R. (2015). Activity of phenolic compounds from plant origin against Candida species. Industrial Crops and Products. ISSN 0926-6690. 74, p. 648-6700926-669010.1016/j.indcrop.2015.05.067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:28:35Zoai:bibliotecadigital.ipb.pt:10198/12427Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:02:34.596545Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Activity of phenolic compounds from plant origin against Candida species
title Activity of phenolic compounds from plant origin against Candida species
spellingShingle Activity of phenolic compounds from plant origin against Candida species
Martins, Natália
Phytochemicals
Plant extracts
Phenolic compounds
Antifungal activity
Candida species
title_short Activity of phenolic compounds from plant origin against Candida species
title_full Activity of phenolic compounds from plant origin against Candida species
title_fullStr Activity of phenolic compounds from plant origin against Candida species
title_full_unstemmed Activity of phenolic compounds from plant origin against Candida species
title_sort Activity of phenolic compounds from plant origin against Candida species
author Martins, Natália
author_facet Martins, Natália
Barros, Lillian
Henriques, Mariana
Silva, Sónia
Ferreira, Isabel C.F.R.
author_role author
author2 Barros, Lillian
Henriques, Mariana
Silva, Sónia
Ferreira, Isabel C.F.R.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Martins, Natália
Barros, Lillian
Henriques, Mariana
Silva, Sónia
Ferreira, Isabel C.F.R.
dc.subject.por.fl_str_mv Phytochemicals
Plant extracts
Phenolic compounds
Antifungal activity
Candida species
topic Phytochemicals
Plant extracts
Phenolic compounds
Antifungal activity
Candida species
description Candida albicans and other Candida species have been highly associated with several opportunistic fungal infections. Their ability to develop host infections is incited by different determinants, being virulence factors the most highlighted. Molecular targets of the antifungal drugs are crucial components for determination of yeast survival. Ergosterol, nucleic acids and glucan are the most studied molecular targets to destroy Candida species, being considered the basis of the development of new antifungal drugs. However, increasing levels of resistant Candida species to the current antifungal drugs have been observed, making ineffective those agents. Thus, other therapies more effective and safer than the current ones, are being studied, namely the use plant of extracts enriched in phenolic compounds. In this sense, this manuscript provide an historical perspective of the opportunistic fungal infections, molecular targets of the current anti-Candida drugs, as well as a general description of the active principles present in plants, focused on the antifungal potential of whole plant extracts and isolated phenolic compounds, against Candida species.
publishDate 2015
dc.date.none.fl_str_mv 2015-11-26T09:50:27Z
2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/12427
url http://hdl.handle.net/10198/12427
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Martins, Natália; Barros, Lillian; Henriques, Mariana; Silva, Sónia; Ferreira, Isabel C.F.R. (2015). Activity of phenolic compounds from plant origin against Candida species. Industrial Crops and Products. ISSN 0926-6690. 74, p. 648-670
0926-6690
10.1016/j.indcrop.2015.05.067
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