Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/37617 |
Resumo: | Increasing rates of opportunistic fungal infections and microorganisms with drug-resistance have been observed. Candida species are the most common pathogens, considered the fourth leading cause of hematogenous infections [1]. Thus, it is crucial to discover alternatives to the current antifungal agents. Healing properties of medicinal plants are widely recognized, but some properties and the related mechanisms of action remain unknown. Therefore, the anti-Candida potential of hydromethanolic extracts obtained from ten folk medicinal plants (Echinacea purpurea L.; Eucalyptus globulus Labill.; Foeniculum vulgare Mill.; Juglans regia L.; Matricaria recutita L.; Melissa officinalis L.; Pterospartum tridentatum L.; Rosa canina L.; Rubus ulmifolius L. and Tabebuia impetiginosa L.) was evaluated, by using disc diffusion assay and determination of minimal inhibitory concentrations by microdilution method. J. regia was the most effective, inhibiting the growth of the tested nineteen Candida strains (halo diameter varying between 9-14 mm) and causing a growth reduction of 3-5 Log(CFUs) for Candida parapsilosis and C. tropicalis, and 0.5-2.5 for C. albicans and C. glabrata. E. globulus also exhibit a significant potential, being effective against seventeen Candida strains (halo diameter ranging between 9-21 mm) and causing a growth reduction of 2-5 Log(CFUs). P. tridentatum and R. ulmifolius showed similar antifungal effects, being effective against six Candida strains (halo diameter ranging between 9-19 mm). So, as main conclusions, hydromethanolic extracts of E. globulus and J. regia could constitute promissory alternatives to the current antifungal agents, but more detailed studies are needed in order to identify the bioactive compounds and related mechanism of action. |
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Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida speciesMedicinal plantsPhenolic extractsAntifungal potentialCandida speciesIncreasing rates of opportunistic fungal infections and microorganisms with drug-resistance have been observed. Candida species are the most common pathogens, considered the fourth leading cause of hematogenous infections [1]. Thus, it is crucial to discover alternatives to the current antifungal agents. Healing properties of medicinal plants are widely recognized, but some properties and the related mechanisms of action remain unknown. Therefore, the anti-Candida potential of hydromethanolic extracts obtained from ten folk medicinal plants (Echinacea purpurea L.; Eucalyptus globulus Labill.; Foeniculum vulgare Mill.; Juglans regia L.; Matricaria recutita L.; Melissa officinalis L.; Pterospartum tridentatum L.; Rosa canina L.; Rubus ulmifolius L. and Tabebuia impetiginosa L.) was evaluated, by using disc diffusion assay and determination of minimal inhibitory concentrations by microdilution method. J. regia was the most effective, inhibiting the growth of the tested nineteen Candida strains (halo diameter varying between 9-14 mm) and causing a growth reduction of 3-5 Log(CFUs) for Candida parapsilosis and C. tropicalis, and 0.5-2.5 for C. albicans and C. glabrata. E. globulus also exhibit a significant potential, being effective against seventeen Candida strains (halo diameter ranging between 9-21 mm) and causing a growth reduction of 2-5 Log(CFUs). P. tridentatum and R. ulmifolius showed similar antifungal effects, being effective against six Candida strains (halo diameter ranging between 9-19 mm). So, as main conclusions, hydromethanolic extracts of E. globulus and J. regia could constitute promissory alternatives to the current antifungal agents, but more detailed studies are needed in order to identify the bioactive compounds and related mechanism of action.OMICS Publishing GroupUniversidade do MinhoMartins, NatáliaFerreira, Isabel C. F. R.Barros, LillianCarvalho, Ana MariaHenriques, MarianaSilva, Sónia Carina2015-082015-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/37617engMartins, N.; Ferreira, Isabel C. F. R.; Barros, Lillian; Carvalho, Ana Maria; Henriques, Mariana; Silva, Sónia Carina, Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species. Chemotherapy: Open Access, 4(2), 54-54, 20152167-7700http://www.omicsgroup.org/journals/chemotherapy-open-access.phpinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:05:02Zoai:repositorium.sdum.uminho.pt:1822/37617Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:55:24.032760Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species |
title |
Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species |
spellingShingle |
Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species Martins, Natália Medicinal plants Phenolic extracts Antifungal potential Candida species |
title_short |
Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species |
title_full |
Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species |
title_fullStr |
Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species |
title_full_unstemmed |
Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species |
title_sort |
Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species |
author |
Martins, Natália |
author_facet |
Martins, Natália Ferreira, Isabel C. F. R. Barros, Lillian Carvalho, Ana Maria Henriques, Mariana Silva, Sónia Carina |
author_role |
author |
author2 |
Ferreira, Isabel C. F. R. Barros, Lillian Carvalho, Ana Maria Henriques, Mariana Silva, Sónia Carina |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Martins, Natália Ferreira, Isabel C. F. R. Barros, Lillian Carvalho, Ana Maria Henriques, Mariana Silva, Sónia Carina |
dc.subject.por.fl_str_mv |
Medicinal plants Phenolic extracts Antifungal potential Candida species |
topic |
Medicinal plants Phenolic extracts Antifungal potential Candida species |
description |
Increasing rates of opportunistic fungal infections and microorganisms with drug-resistance have been observed. Candida species are the most common pathogens, considered the fourth leading cause of hematogenous infections [1]. Thus, it is crucial to discover alternatives to the current antifungal agents. Healing properties of medicinal plants are widely recognized, but some properties and the related mechanisms of action remain unknown. Therefore, the anti-Candida potential of hydromethanolic extracts obtained from ten folk medicinal plants (Echinacea purpurea L.; Eucalyptus globulus Labill.; Foeniculum vulgare Mill.; Juglans regia L.; Matricaria recutita L.; Melissa officinalis L.; Pterospartum tridentatum L.; Rosa canina L.; Rubus ulmifolius L. and Tabebuia impetiginosa L.) was evaluated, by using disc diffusion assay and determination of minimal inhibitory concentrations by microdilution method. J. regia was the most effective, inhibiting the growth of the tested nineteen Candida strains (halo diameter varying between 9-14 mm) and causing a growth reduction of 3-5 Log(CFUs) for Candida parapsilosis and C. tropicalis, and 0.5-2.5 for C. albicans and C. glabrata. E. globulus also exhibit a significant potential, being effective against seventeen Candida strains (halo diameter ranging between 9-21 mm) and causing a growth reduction of 2-5 Log(CFUs). P. tridentatum and R. ulmifolius showed similar antifungal effects, being effective against six Candida strains (halo diameter ranging between 9-19 mm). So, as main conclusions, hydromethanolic extracts of E. globulus and J. regia could constitute promissory alternatives to the current antifungal agents, but more detailed studies are needed in order to identify the bioactive compounds and related mechanism of action. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-08 2015-08-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/37617 |
url |
http://hdl.handle.net/1822/37617 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Martins, N.; Ferreira, Isabel C. F. R.; Barros, Lillian; Carvalho, Ana Maria; Henriques, Mariana; Silva, Sónia Carina, Folk medicinal plant extracts as a source of biomolecules with antifungal properties against Candida species. Chemotherapy: Open Access, 4(2), 54-54, 2015 2167-7700 http://www.omicsgroup.org/journals/chemotherapy-open-access.php |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
OMICS Publishing Group |
publisher.none.fl_str_mv |
OMICS Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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