Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder

Detalhes bibliográficos
Autor(a) principal: Gomes, Joana I.
Data de Publicação: 2021
Outros Autores: Farinha Ferreira, Jorge Miguel, Rei, Nádia, Gonçalves-Ribeiro, Joana, Ribeiro, Joaquim A., Sebastião, Ana M, Vaz, Sandra H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47247
Resumo: © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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spelling Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorderAdenosineAdenosinergic systemAntidepressantsAnxietyMajor Depressive Disorder© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Major depressive disorder (MDD) is the foremost cause of global disability, being responsible for enormous personal, societal, and economical costs. Importantly, existing pharmacological treatments for MDD are partially or totally ineffective in a large segment of patients. As such, the search for novel antidepressant drug targets, anchored on a clear understanding of the etiological and pathophysiological mechanisms underpinning MDD, becomes of the utmost importance. The adenosinergic system, a highly conserved neuromodulatory system, appears as a promising novel target, given both its regulatory actions over many MDD-affected systems and processes. With this goal in mind, we herein review the evidence concerning the role of adenosine as a potential player in pathophysiology and treatment of MDD, combining data from both human and animal studies. Altogether, evidence supports the assertions that the adenosinergic system is altered in both MDD patients and animal models, and that drugs targeting this system have considerable potential as putative antidepressants. Furthermore, evidence also suggests that modifications in adenosine signaling may have a key role in the effects of several pharmacological and non-pharmacological antidepressant treatments with demonstrated efficacy, such as electroconvulsive shock, sleep deprivation, and deep brain stimulation. Lastly, it becomes clear from the available literature that there is yet much to study regarding the role of the adenosinergic system in the pathophysiology and treatment of MDD, and we suggest several avenues of research that are likely to prove fruitful.This work was supported by project funding from Fundação para a Ciência e para a Tecnologia (FCT) to SHV (PTDC/BTM-SAL/32147/2017) and AMS (PTDC/MED-FAR/30933/2017). This project has received funding from H2020-WIDESPREAD-05-2017-Twinning (EpiEpinet) under grant agreement No. 952455. MF-F (SFRH/BD/147505/2019), JG-R (PD/BD/150342/2019), and NR (PD/BD/113463/2015) are supported by PhD fellowships from FCT.ElsevierRepositório da Universidade de LisboaGomes, Joana I.Farinha Ferreira, Jorge MiguelRei, NádiaGonçalves-Ribeiro, JoanaRibeiro, Joaquim A.Sebastião, Ana MVaz, Sandra H.2021-04-06T11:54:09Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47247engPharmacol Res. 2021 Jan;163:1053631043-661810.1016/j.phrs.2020.1053631096-1186info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:50:00Zoai:repositorio.ul.pt:10451/47247Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:19.084173Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder
title Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder
spellingShingle Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder
Gomes, Joana I.
Adenosine
Adenosinergic system
Antidepressants
Anxiety
Major Depressive Disorder
title_short Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder
title_full Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder
title_fullStr Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder
title_full_unstemmed Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder
title_sort Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder
author Gomes, Joana I.
author_facet Gomes, Joana I.
Farinha Ferreira, Jorge Miguel
Rei, Nádia
Gonçalves-Ribeiro, Joana
Ribeiro, Joaquim A.
Sebastião, Ana M
Vaz, Sandra H.
author_role author
author2 Farinha Ferreira, Jorge Miguel
Rei, Nádia
Gonçalves-Ribeiro, Joana
Ribeiro, Joaquim A.
Sebastião, Ana M
Vaz, Sandra H.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Gomes, Joana I.
Farinha Ferreira, Jorge Miguel
Rei, Nádia
Gonçalves-Ribeiro, Joana
Ribeiro, Joaquim A.
Sebastião, Ana M
Vaz, Sandra H.
dc.subject.por.fl_str_mv Adenosine
Adenosinergic system
Antidepressants
Anxiety
Major Depressive Disorder
topic Adenosine
Adenosinergic system
Antidepressants
Anxiety
Major Depressive Disorder
description © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
publishDate 2021
dc.date.none.fl_str_mv 2021-04-06T11:54:09Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47247
url http://hdl.handle.net/10451/47247
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmacol Res. 2021 Jan;163:105363
1043-6618
10.1016/j.phrs.2020.105363
1096-1186
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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instacron_str RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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