Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/47247 |
Resumo: | © 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
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Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorderAdenosineAdenosinergic systemAntidepressantsAnxietyMajor Depressive Disorder© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Major depressive disorder (MDD) is the foremost cause of global disability, being responsible for enormous personal, societal, and economical costs. Importantly, existing pharmacological treatments for MDD are partially or totally ineffective in a large segment of patients. As such, the search for novel antidepressant drug targets, anchored on a clear understanding of the etiological and pathophysiological mechanisms underpinning MDD, becomes of the utmost importance. The adenosinergic system, a highly conserved neuromodulatory system, appears as a promising novel target, given both its regulatory actions over many MDD-affected systems and processes. With this goal in mind, we herein review the evidence concerning the role of adenosine as a potential player in pathophysiology and treatment of MDD, combining data from both human and animal studies. Altogether, evidence supports the assertions that the adenosinergic system is altered in both MDD patients and animal models, and that drugs targeting this system have considerable potential as putative antidepressants. Furthermore, evidence also suggests that modifications in adenosine signaling may have a key role in the effects of several pharmacological and non-pharmacological antidepressant treatments with demonstrated efficacy, such as electroconvulsive shock, sleep deprivation, and deep brain stimulation. Lastly, it becomes clear from the available literature that there is yet much to study regarding the role of the adenosinergic system in the pathophysiology and treatment of MDD, and we suggest several avenues of research that are likely to prove fruitful.This work was supported by project funding from Fundação para a Ciência e para a Tecnologia (FCT) to SHV (PTDC/BTM-SAL/32147/2017) and AMS (PTDC/MED-FAR/30933/2017). This project has received funding from H2020-WIDESPREAD-05-2017-Twinning (EpiEpinet) under grant agreement No. 952455. MF-F (SFRH/BD/147505/2019), JG-R (PD/BD/150342/2019), and NR (PD/BD/113463/2015) are supported by PhD fellowships from FCT.ElsevierRepositório da Universidade de LisboaGomes, Joana I.Farinha Ferreira, Jorge MiguelRei, NádiaGonçalves-Ribeiro, JoanaRibeiro, Joaquim A.Sebastião, Ana MVaz, Sandra H.2021-04-06T11:54:09Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47247engPharmacol Res. 2021 Jan;163:1053631043-661810.1016/j.phrs.2020.1053631096-1186info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:50:00Zoai:repositorio.ul.pt:10451/47247Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:19.084173Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder |
title |
Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder |
spellingShingle |
Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder Gomes, Joana I. Adenosine Adenosinergic system Antidepressants Anxiety Major Depressive Disorder |
title_short |
Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder |
title_full |
Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder |
title_fullStr |
Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder |
title_full_unstemmed |
Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder |
title_sort |
Of adenosine and the blues: the adenosinergic system in the pathophysiology and treatment of major depressive disorder |
author |
Gomes, Joana I. |
author_facet |
Gomes, Joana I. Farinha Ferreira, Jorge Miguel Rei, Nádia Gonçalves-Ribeiro, Joana Ribeiro, Joaquim A. Sebastião, Ana M Vaz, Sandra H. |
author_role |
author |
author2 |
Farinha Ferreira, Jorge Miguel Rei, Nádia Gonçalves-Ribeiro, Joana Ribeiro, Joaquim A. Sebastião, Ana M Vaz, Sandra H. |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Gomes, Joana I. Farinha Ferreira, Jorge Miguel Rei, Nádia Gonçalves-Ribeiro, Joana Ribeiro, Joaquim A. Sebastião, Ana M Vaz, Sandra H. |
dc.subject.por.fl_str_mv |
Adenosine Adenosinergic system Antidepressants Anxiety Major Depressive Disorder |
topic |
Adenosine Adenosinergic system Antidepressants Anxiety Major Depressive Disorder |
description |
© 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-04-06T11:54:09Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/47247 |
url |
http://hdl.handle.net/10451/47247 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmacol Res. 2021 Jan;163:105363 1043-6618 10.1016/j.phrs.2020.105363 1096-1186 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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