How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/8653 |
Resumo: | One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/poly-fluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations. |
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How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EUEnvironmental GenotoxicityHuman BiomonitoringRisk AssessmentChemical ExposureBiomarkerEnvironmental Burden of DiseaseAvaliação do RiscoChemicalsHBM4EUGenotoxicidade AmbientalOne of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/poly-fluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations..Funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 733032 HBM4EU, and co-funding from the authors' organisations.ElsevierRepositório Científico do Instituto Nacional de SaúdeSantonen, TiinaMahiout, SelmaAlvito, PaulaApel, PetraBessems, JosBil, WienekeBorges, TeresaBose-O'Reilly, StephanBuekers, JurgenCañas Portilla, Ana IsabelCalvo, Argelia Castañode Alba González, MercedesDomínguez-Morueco, NoeliaLópez, Marta EstebanFalnoga, IngridGerofke, AntjeCaballero, María del Carmen GonzálezHorvat, MilenaHuuskonen, PasiKadikis, NormundsKolossa-Gehring, MarikeLange, RosaLouro, HenriquetaMartins, CarlaMeslin, MatthieuNiemann, LarsDíaz, Susana PedrazaPlichta, VeronikaPorras, Simo P.Rousselle, ChristopheScholten, BerniceSilva, Maria JoãoŠlejkovec, ZdenkaTratnik, Janja SnojJoksić, Agnes ŠömenTarazona, Jose V.Uhl, MariaVan Nieuwenhuyse, AnViegas, SusanaVinggaard, Anne MarieWoutersen, MarjolijnSchoeters, Greet2023-10-04T13:48:05Z2023-03-022023-03-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8653engInt J Hyg Environ Health. 2023 Apr;249:114139. doi: 10.1016/j.ijheh.2023.114139. Epub 2023 Mar 21438-463910.1016/j.ijheh.2023.114139info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-07T01:31:04Zoai:repositorio.insa.pt:10400.18/8653Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:33:34.348302Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU |
title |
How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU |
spellingShingle |
How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU Santonen, Tiina Environmental Genotoxicity Human Biomonitoring Risk Assessment Chemical Exposure Biomarker Environmental Burden of Disease Avaliação do Risco Chemicals HBM4EU Genotoxicidade Ambiental |
title_short |
How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU |
title_full |
How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU |
title_fullStr |
How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU |
title_full_unstemmed |
How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU |
title_sort |
How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU |
author |
Santonen, Tiina |
author_facet |
Santonen, Tiina Mahiout, Selma Alvito, Paula Apel, Petra Bessems, Jos Bil, Wieneke Borges, Teresa Bose-O'Reilly, Stephan Buekers, Jurgen Cañas Portilla, Ana Isabel Calvo, Argelia Castaño de Alba González, Mercedes Domínguez-Morueco, Noelia López, Marta Esteban Falnoga, Ingrid Gerofke, Antje Caballero, María del Carmen González Horvat, Milena Huuskonen, Pasi Kadikis, Normunds Kolossa-Gehring, Marike Lange, Rosa Louro, Henriqueta Martins, Carla Meslin, Matthieu Niemann, Lars Díaz, Susana Pedraza Plichta, Veronika Porras, Simo P. Rousselle, Christophe Scholten, Bernice Silva, Maria João Šlejkovec, Zdenka Tratnik, Janja Snoj Joksić, Agnes Šömen Tarazona, Jose V. Uhl, Maria Van Nieuwenhuyse, An Viegas, Susana Vinggaard, Anne Marie Woutersen, Marjolijn Schoeters, Greet |
author_role |
author |
author2 |
Mahiout, Selma Alvito, Paula Apel, Petra Bessems, Jos Bil, Wieneke Borges, Teresa Bose-O'Reilly, Stephan Buekers, Jurgen Cañas Portilla, Ana Isabel Calvo, Argelia Castaño de Alba González, Mercedes Domínguez-Morueco, Noelia López, Marta Esteban Falnoga, Ingrid Gerofke, Antje Caballero, María del Carmen González Horvat, Milena Huuskonen, Pasi Kadikis, Normunds Kolossa-Gehring, Marike Lange, Rosa Louro, Henriqueta Martins, Carla Meslin, Matthieu Niemann, Lars Díaz, Susana Pedraza Plichta, Veronika Porras, Simo P. Rousselle, Christophe Scholten, Bernice Silva, Maria João Šlejkovec, Zdenka Tratnik, Janja Snoj Joksić, Agnes Šömen Tarazona, Jose V. Uhl, Maria Van Nieuwenhuyse, An Viegas, Susana Vinggaard, Anne Marie Woutersen, Marjolijn Schoeters, Greet |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Santonen, Tiina Mahiout, Selma Alvito, Paula Apel, Petra Bessems, Jos Bil, Wieneke Borges, Teresa Bose-O'Reilly, Stephan Buekers, Jurgen Cañas Portilla, Ana Isabel Calvo, Argelia Castaño de Alba González, Mercedes Domínguez-Morueco, Noelia López, Marta Esteban Falnoga, Ingrid Gerofke, Antje Caballero, María del Carmen González Horvat, Milena Huuskonen, Pasi Kadikis, Normunds Kolossa-Gehring, Marike Lange, Rosa Louro, Henriqueta Martins, Carla Meslin, Matthieu Niemann, Lars Díaz, Susana Pedraza Plichta, Veronika Porras, Simo P. Rousselle, Christophe Scholten, Bernice Silva, Maria João Šlejkovec, Zdenka Tratnik, Janja Snoj Joksić, Agnes Šömen Tarazona, Jose V. Uhl, Maria Van Nieuwenhuyse, An Viegas, Susana Vinggaard, Anne Marie Woutersen, Marjolijn Schoeters, Greet |
dc.subject.por.fl_str_mv |
Environmental Genotoxicity Human Biomonitoring Risk Assessment Chemical Exposure Biomarker Environmental Burden of Disease Avaliação do Risco Chemicals HBM4EU Genotoxicidade Ambiental |
topic |
Environmental Genotoxicity Human Biomonitoring Risk Assessment Chemical Exposure Biomarker Environmental Burden of Disease Avaliação do Risco Chemicals HBM4EU Genotoxicidade Ambiental |
description |
One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/poly-fluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-10-04T13:48:05Z 2023-03-02 2023-03-02T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8653 |
url |
http://hdl.handle.net/10400.18/8653 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Int J Hyg Environ Health. 2023 Apr;249:114139. doi: 10.1016/j.ijheh.2023.114139. Epub 2023 Mar 2 1438-4639 10.1016/j.ijheh.2023.114139 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799133601053278208 |