How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU

Detalhes bibliográficos
Autor(a) principal: Santonen, Tiina
Data de Publicação: 2023
Outros Autores: Mahiout, Selma, Alvito, Paula, Apel, Petra, Bessems, Jos, Bil, Wieneke, Borges, Teresa, Bose-O'Reilly, Stephan, Buekers, Jurgen, Cañas Portilla, Ana Isabel, Calvo, Argelia Castaño, de Alba González, Mercedes, Domínguez-Morueco, Noelia, López, Marta Esteban, Falnoga, Ingrid, Gerofke, Antje, Caballero, María del Carmen González, Horvat, Milena, Huuskonen, Pasi, Kadikis, Normunds, Kolossa-Gehring, Marike, Lange, Rosa, Louro, Henriqueta, Martins, Carla, Meslin, Matthieu, Niemann, Lars, Díaz, Susana Pedraza, Plichta, Veronika, Porras, Simo P., Rousselle, Christophe, Scholten, Bernice, Silva, Maria João, Šlejkovec, Zdenka, Tratnik, Janja Snoj, Joksić, Agnes Šömen, Tarazona, Jose V., Uhl, Maria, Van Nieuwenhuyse, An, Viegas, Susana, Vinggaard, Anne Marie, Woutersen, Marjolijn, Schoeters, Greet
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8653
Resumo: One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/poly-fluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations.
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spelling How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EUEnvironmental GenotoxicityHuman BiomonitoringRisk AssessmentChemical ExposureBiomarkerEnvironmental Burden of DiseaseAvaliação do RiscoChemicalsHBM4EUGenotoxicidade AmbientalOne of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/poly-fluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations..Funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 733032 HBM4EU, and co-funding from the authors' organisations.ElsevierRepositório Científico do Instituto Nacional de SaúdeSantonen, TiinaMahiout, SelmaAlvito, PaulaApel, PetraBessems, JosBil, WienekeBorges, TeresaBose-O'Reilly, StephanBuekers, JurgenCañas Portilla, Ana IsabelCalvo, Argelia Castañode Alba González, MercedesDomínguez-Morueco, NoeliaLópez, Marta EstebanFalnoga, IngridGerofke, AntjeCaballero, María del Carmen GonzálezHorvat, MilenaHuuskonen, PasiKadikis, NormundsKolossa-Gehring, MarikeLange, RosaLouro, HenriquetaMartins, CarlaMeslin, MatthieuNiemann, LarsDíaz, Susana PedrazaPlichta, VeronikaPorras, Simo P.Rousselle, ChristopheScholten, BerniceSilva, Maria JoãoŠlejkovec, ZdenkaTratnik, Janja SnojJoksić, Agnes ŠömenTarazona, Jose V.Uhl, MariaVan Nieuwenhuyse, AnViegas, SusanaVinggaard, Anne MarieWoutersen, MarjolijnSchoeters, Greet2023-10-04T13:48:05Z2023-03-022023-03-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8653engInt J Hyg Environ Health. 2023 Apr;249:114139. doi: 10.1016/j.ijheh.2023.114139. Epub 2023 Mar 21438-463910.1016/j.ijheh.2023.114139info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-07T01:31:04Zoai:repositorio.insa.pt:10400.18/8653Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:33:34.348302Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
title How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
spellingShingle How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
Santonen, Tiina
Environmental Genotoxicity
Human Biomonitoring
Risk Assessment
Chemical Exposure
Biomarker
Environmental Burden of Disease
Avaliação do Risco
Chemicals
HBM4EU
Genotoxicidade Ambiental
title_short How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
title_full How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
title_fullStr How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
title_full_unstemmed How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
title_sort How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
author Santonen, Tiina
author_facet Santonen, Tiina
Mahiout, Selma
Alvito, Paula
Apel, Petra
Bessems, Jos
Bil, Wieneke
Borges, Teresa
Bose-O'Reilly, Stephan
Buekers, Jurgen
Cañas Portilla, Ana Isabel
Calvo, Argelia Castaño
de Alba González, Mercedes
Domínguez-Morueco, Noelia
López, Marta Esteban
Falnoga, Ingrid
Gerofke, Antje
Caballero, María del Carmen González
Horvat, Milena
Huuskonen, Pasi
Kadikis, Normunds
Kolossa-Gehring, Marike
Lange, Rosa
Louro, Henriqueta
Martins, Carla
Meslin, Matthieu
Niemann, Lars
Díaz, Susana Pedraza
Plichta, Veronika
Porras, Simo P.
Rousselle, Christophe
Scholten, Bernice
Silva, Maria João
Šlejkovec, Zdenka
Tratnik, Janja Snoj
Joksić, Agnes Šömen
Tarazona, Jose V.
Uhl, Maria
Van Nieuwenhuyse, An
Viegas, Susana
Vinggaard, Anne Marie
Woutersen, Marjolijn
Schoeters, Greet
author_role author
author2 Mahiout, Selma
Alvito, Paula
Apel, Petra
Bessems, Jos
Bil, Wieneke
Borges, Teresa
Bose-O'Reilly, Stephan
Buekers, Jurgen
Cañas Portilla, Ana Isabel
Calvo, Argelia Castaño
de Alba González, Mercedes
Domínguez-Morueco, Noelia
López, Marta Esteban
Falnoga, Ingrid
Gerofke, Antje
Caballero, María del Carmen González
Horvat, Milena
Huuskonen, Pasi
Kadikis, Normunds
Kolossa-Gehring, Marike
Lange, Rosa
Louro, Henriqueta
Martins, Carla
Meslin, Matthieu
Niemann, Lars
Díaz, Susana Pedraza
Plichta, Veronika
Porras, Simo P.
Rousselle, Christophe
Scholten, Bernice
Silva, Maria João
Šlejkovec, Zdenka
Tratnik, Janja Snoj
Joksić, Agnes Šömen
Tarazona, Jose V.
Uhl, Maria
Van Nieuwenhuyse, An
Viegas, Susana
Vinggaard, Anne Marie
Woutersen, Marjolijn
Schoeters, Greet
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
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author
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author
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author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Santonen, Tiina
Mahiout, Selma
Alvito, Paula
Apel, Petra
Bessems, Jos
Bil, Wieneke
Borges, Teresa
Bose-O'Reilly, Stephan
Buekers, Jurgen
Cañas Portilla, Ana Isabel
Calvo, Argelia Castaño
de Alba González, Mercedes
Domínguez-Morueco, Noelia
López, Marta Esteban
Falnoga, Ingrid
Gerofke, Antje
Caballero, María del Carmen González
Horvat, Milena
Huuskonen, Pasi
Kadikis, Normunds
Kolossa-Gehring, Marike
Lange, Rosa
Louro, Henriqueta
Martins, Carla
Meslin, Matthieu
Niemann, Lars
Díaz, Susana Pedraza
Plichta, Veronika
Porras, Simo P.
Rousselle, Christophe
Scholten, Bernice
Silva, Maria João
Šlejkovec, Zdenka
Tratnik, Janja Snoj
Joksić, Agnes Šömen
Tarazona, Jose V.
Uhl, Maria
Van Nieuwenhuyse, An
Viegas, Susana
Vinggaard, Anne Marie
Woutersen, Marjolijn
Schoeters, Greet
dc.subject.por.fl_str_mv Environmental Genotoxicity
Human Biomonitoring
Risk Assessment
Chemical Exposure
Biomarker
Environmental Burden of Disease
Avaliação do Risco
Chemicals
HBM4EU
Genotoxicidade Ambiental
topic Environmental Genotoxicity
Human Biomonitoring
Risk Assessment
Chemical Exposure
Biomarker
Environmental Burden of Disease
Avaliação do Risco
Chemicals
HBM4EU
Genotoxicidade Ambiental
description One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/poly-fluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations.
publishDate 2023
dc.date.none.fl_str_mv 2023-10-04T13:48:05Z
2023-03-02
2023-03-02T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8653
url http://hdl.handle.net/10400.18/8653
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Int J Hyg Environ Health. 2023 Apr;249:114139. doi: 10.1016/j.ijheh.2023.114139. Epub 2023 Mar 2
1438-4639
10.1016/j.ijheh.2023.114139
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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