How to use human biomonitoring in chemical risk assessment
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/150480 |
Resumo: | Funding: This project received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733032 HBM4EU, and co-funding from the authors’ organisations. The results presented here are based on a huge body of work performed as part of Task 5.3 of the HBM4EU in 2017–2022. First and foremost, we would like to acknowledge all our Task 5.3 colleagues for their valuable contribution to the project work, including the individual RAs and EBoD calculations. In addition, we would like to thank all our other HBM4EU colleagues, the HBM4EU-aligned study data owners, and the other stakeholders who provided support for and feedback on our work during its course. |
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How to use human biomonitoring in chemical risk assessmentMethodological aspects, recommendations, and lessons learned from HBM4EUChemicalsEnvironmental burden of diseaseExposure biomarkersHBM4EUHuman biomonitoringRisk assessmentSDG 3 - Good Health and Well-beingFunding: This project received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733032 HBM4EU, and co-funding from the authors’ organisations. The results presented here are based on a huge body of work performed as part of Task 5.3 of the HBM4EU in 2017–2022. First and foremost, we would like to acknowledge all our Task 5.3 colleagues for their valuable contribution to the project work, including the individual RAs and EBoD calculations. In addition, we would like to thank all our other HBM4EU colleagues, the HBM4EU-aligned study data owners, and the other stakeholders who provided support for and feedback on our work during its course.One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/poly-fluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centro de Investigação em Saúde Pública (CISP/PHRC)Comprehensive Health Research Centre (CHRC) - Pólo ENSPEscola Nacional de Saúde Pública (ENSP)RUNSantonen, TiinaMahiout, SelmaAlvito, PaulaApel, PetraBessems, JosBil, WienekeBorges, TeresaBose-O'Reilly, StephanBuekers, JurgenCañas Portilla, Ana IsabelCalvo, Argelia Castañode Alba González, MercedesDomínguez-Morueco, NoeliaLópez, Marta EstebanFalnoga, IngridGerofke, AntjeCaballero, María Del Carmen GonzálezHorvat, MilenaHuuskonen, PasiKadikis, NormundsKolossa-Gehring, MarikeLange, RosaLouro, HenriquetaMartins, CarlaMeslin, MatthieuNiemann, LarsDíaz, Susana PedrazaPlichta, VeronikaPorras, Simo PRousselle, ChristopheScholten, BerniceSilva, Maria JoãoŠlejkovec, ZdenkaTratnik, Janja SnojJoksić, Agnes ŠömenTarazona, Jose VUhl, MariaVan Nieuwenhuyse, AnViegas, SusanaVinggaard, Anne MarieWoutersen, MarjolijnSchoeters, Greet2023-03-13T22:26:02Z2023-042023-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/150480eng1438-4639PURE: 54916338https://doi.org/10.1016/j.ijheh.2023.114139info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:32:27Zoai:run.unl.pt:10362/150480Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:54:08.352539Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
How to use human biomonitoring in chemical risk assessment Methodological aspects, recommendations, and lessons learned from HBM4EU |
title |
How to use human biomonitoring in chemical risk assessment |
spellingShingle |
How to use human biomonitoring in chemical risk assessment Santonen, Tiina Chemicals Environmental burden of disease Exposure biomarkers HBM4EU Human biomonitoring Risk assessment SDG 3 - Good Health and Well-being |
title_short |
How to use human biomonitoring in chemical risk assessment |
title_full |
How to use human biomonitoring in chemical risk assessment |
title_fullStr |
How to use human biomonitoring in chemical risk assessment |
title_full_unstemmed |
How to use human biomonitoring in chemical risk assessment |
title_sort |
How to use human biomonitoring in chemical risk assessment |
author |
Santonen, Tiina |
author_facet |
Santonen, Tiina Mahiout, Selma Alvito, Paula Apel, Petra Bessems, Jos Bil, Wieneke Borges, Teresa Bose-O'Reilly, Stephan Buekers, Jurgen Cañas Portilla, Ana Isabel Calvo, Argelia Castaño de Alba González, Mercedes Domínguez-Morueco, Noelia López, Marta Esteban Falnoga, Ingrid Gerofke, Antje Caballero, María Del Carmen González Horvat, Milena Huuskonen, Pasi Kadikis, Normunds Kolossa-Gehring, Marike Lange, Rosa Louro, Henriqueta Martins, Carla Meslin, Matthieu Niemann, Lars Díaz, Susana Pedraza Plichta, Veronika Porras, Simo P Rousselle, Christophe Scholten, Bernice Silva, Maria João Šlejkovec, Zdenka Tratnik, Janja Snoj Joksić, Agnes Šömen Tarazona, Jose V Uhl, Maria Van Nieuwenhuyse, An Viegas, Susana Vinggaard, Anne Marie Woutersen, Marjolijn Schoeters, Greet |
author_role |
author |
author2 |
Mahiout, Selma Alvito, Paula Apel, Petra Bessems, Jos Bil, Wieneke Borges, Teresa Bose-O'Reilly, Stephan Buekers, Jurgen Cañas Portilla, Ana Isabel Calvo, Argelia Castaño de Alba González, Mercedes Domínguez-Morueco, Noelia López, Marta Esteban Falnoga, Ingrid Gerofke, Antje Caballero, María Del Carmen González Horvat, Milena Huuskonen, Pasi Kadikis, Normunds Kolossa-Gehring, Marike Lange, Rosa Louro, Henriqueta Martins, Carla Meslin, Matthieu Niemann, Lars Díaz, Susana Pedraza Plichta, Veronika Porras, Simo P Rousselle, Christophe Scholten, Bernice Silva, Maria João Šlejkovec, Zdenka Tratnik, Janja Snoj Joksić, Agnes Šömen Tarazona, Jose V Uhl, Maria Van Nieuwenhuyse, An Viegas, Susana Vinggaard, Anne Marie Woutersen, Marjolijn Schoeters, Greet |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Centre for Toxicogenomics and Human Health (ToxOmics) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Centro de Investigação em Saúde Pública (CISP/PHRC) Comprehensive Health Research Centre (CHRC) - Pólo ENSP Escola Nacional de Saúde Pública (ENSP) RUN |
dc.contributor.author.fl_str_mv |
Santonen, Tiina Mahiout, Selma Alvito, Paula Apel, Petra Bessems, Jos Bil, Wieneke Borges, Teresa Bose-O'Reilly, Stephan Buekers, Jurgen Cañas Portilla, Ana Isabel Calvo, Argelia Castaño de Alba González, Mercedes Domínguez-Morueco, Noelia López, Marta Esteban Falnoga, Ingrid Gerofke, Antje Caballero, María Del Carmen González Horvat, Milena Huuskonen, Pasi Kadikis, Normunds Kolossa-Gehring, Marike Lange, Rosa Louro, Henriqueta Martins, Carla Meslin, Matthieu Niemann, Lars Díaz, Susana Pedraza Plichta, Veronika Porras, Simo P Rousselle, Christophe Scholten, Bernice Silva, Maria João Šlejkovec, Zdenka Tratnik, Janja Snoj Joksić, Agnes Šömen Tarazona, Jose V Uhl, Maria Van Nieuwenhuyse, An Viegas, Susana Vinggaard, Anne Marie Woutersen, Marjolijn Schoeters, Greet |
dc.subject.por.fl_str_mv |
Chemicals Environmental burden of disease Exposure biomarkers HBM4EU Human biomonitoring Risk assessment SDG 3 - Good Health and Well-being |
topic |
Chemicals Environmental burden of disease Exposure biomarkers HBM4EU Human biomonitoring Risk assessment SDG 3 - Good Health and Well-being |
description |
Funding: This project received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733032 HBM4EU, and co-funding from the authors’ organisations. The results presented here are based on a huge body of work performed as part of Task 5.3 of the HBM4EU in 2017–2022. First and foremost, we would like to acknowledge all our Task 5.3 colleagues for their valuable contribution to the project work, including the individual RAs and EBoD calculations. In addition, we would like to thank all our other HBM4EU colleagues, the HBM4EU-aligned study data owners, and the other stakeholders who provided support for and feedback on our work during its course. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-13T22:26:02Z 2023-04 2023-04-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/150480 |
url |
http://hdl.handle.net/10362/150480 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1438-4639 PURE: 54916338 https://doi.org/10.1016/j.ijheh.2023.114139 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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