Predictive biomarkers in colorectal cancer: from the single therapeutic target to a plethora of options

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Daniela
Data de Publicação: 2016
Outros Autores: Longatto Filho, Adhemar, Martins, Sandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/45143
Resumo: Colorectal cancer (CRC) is one of the most frequent cancers and is a leading cause of cancer death worldwide. Treatments used for CRC may include some combination of surgery, radiation therapy, chemotherapy, and targeted therapy. The current standard drugs used in chemotherapy are 5-fluorouracil and leucovorin in combination with irinotecan and/or oxaliplatin. Most recently, biologic agents have been proven to have therapeutic benefits in metastatic CRC alone or in association with standard chemotherapy. However, patients present different treatment responses, in terms of efficacy and toxicity; therefore, it is important to identify biological markers that can predict the response to therapy and help select patients that would benefit from specific regimens. In this paper, authors review CRC genetic markers that could be useful in predicting the sensitivity/resistance to chemotherapy.
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spelling Predictive biomarkers in colorectal cancer: from the single therapeutic target to a plethora of optionsScience & TechnologyColorectal cancer (CRC) is one of the most frequent cancers and is a leading cause of cancer death worldwide. Treatments used for CRC may include some combination of surgery, radiation therapy, chemotherapy, and targeted therapy. The current standard drugs used in chemotherapy are 5-fluorouracil and leucovorin in combination with irinotecan and/or oxaliplatin. Most recently, biologic agents have been proven to have therapeutic benefits in metastatic CRC alone or in association with standard chemotherapy. However, patients present different treatment responses, in terms of efficacy and toxicity; therefore, it is important to identify biological markers that can predict the response to therapy and help select patients that would benefit from specific regimens. In this paper, authors review CRC genetic markers that could be useful in predicting the sensitivity/resistance to chemotherapy.info:eu-repo/semantics/publishedVersionHindawi Publishing CorporationUniversidade do MinhoRodrigues, DanielaLongatto Filho, AdhemarMartins, Sandra20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/45143engRodrigues, D., Longatto-Filho, A., & Martins, S. F. (2016). Predictive Biomarkers in Colorectal Cancer: From the Single Therapeutic Target to a Plethora of Options. [Review]. BioMed Research International, 2016. doi: 10.1155/2016/68960242314-613310.1155/2016/689602427563673https://www.hindawi.com/journals/bmri/2016/6896024/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T04:55:29Zoai:repositorium.sdum.uminho.pt:1822/45143Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T04:55:29Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Predictive biomarkers in colorectal cancer: from the single therapeutic target to a plethora of options
title Predictive biomarkers in colorectal cancer: from the single therapeutic target to a plethora of options
spellingShingle Predictive biomarkers in colorectal cancer: from the single therapeutic target to a plethora of options
Rodrigues, Daniela
Science & Technology
title_short Predictive biomarkers in colorectal cancer: from the single therapeutic target to a plethora of options
title_full Predictive biomarkers in colorectal cancer: from the single therapeutic target to a plethora of options
title_fullStr Predictive biomarkers in colorectal cancer: from the single therapeutic target to a plethora of options
title_full_unstemmed Predictive biomarkers in colorectal cancer: from the single therapeutic target to a plethora of options
title_sort Predictive biomarkers in colorectal cancer: from the single therapeutic target to a plethora of options
author Rodrigues, Daniela
author_facet Rodrigues, Daniela
Longatto Filho, Adhemar
Martins, Sandra
author_role author
author2 Longatto Filho, Adhemar
Martins, Sandra
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Rodrigues, Daniela
Longatto Filho, Adhemar
Martins, Sandra
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description Colorectal cancer (CRC) is one of the most frequent cancers and is a leading cause of cancer death worldwide. Treatments used for CRC may include some combination of surgery, radiation therapy, chemotherapy, and targeted therapy. The current standard drugs used in chemotherapy are 5-fluorouracil and leucovorin in combination with irinotecan and/or oxaliplatin. Most recently, biologic agents have been proven to have therapeutic benefits in metastatic CRC alone or in association with standard chemotherapy. However, patients present different treatment responses, in terms of efficacy and toxicity; therefore, it is important to identify biological markers that can predict the response to therapy and help select patients that would benefit from specific regimens. In this paper, authors review CRC genetic markers that could be useful in predicting the sensitivity/resistance to chemotherapy.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/45143
url http://hdl.handle.net/1822/45143
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rodrigues, D., Longatto-Filho, A., & Martins, S. F. (2016). Predictive Biomarkers in Colorectal Cancer: From the Single Therapeutic Target to a Plethora of Options. [Review]. BioMed Research International, 2016. doi: 10.1155/2016/6896024
2314-6133
10.1155/2016/6896024
27563673
https://www.hindawi.com/journals/bmri/2016/6896024/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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