Finding the perfect match between nanoparticles and microfluidics to respond to cancer challenges

Detalhes bibliográficos
Autor(a) principal: Maia, F. Raquel
Data de Publicação: 2020
Outros Autores: Reis, R. L., Oliveira, Joaquim M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/66388
Resumo: The clinical translation of new cancer theranostic has been delayed by inherent cancerâ s heterogeneity. Additionally, this delay has been enhanced by the lack of an appropriate in vitro model, capable to produce accurate data. Nanoparticles and microfluidic devices have been used to obtain new and more efficient strategies to tackle cancer challenges. On one hand, nanoparticles-based therapeutics can be modified to target specific cells, and/or molecules, and/or modified with drugs, releasing them over time. On the other hand, microfluidic devices allow the exhibition of physiologically complex systems, incorporation of controlled flow, and control of the chemical environment. Herein, we review the use of nanoparticles and microfluidic devices to address different cancer challenges, such as detection of CTCs and biomarkers, point-of-care devices for early diagnosis and improvement of therapies. The future perspectives of cancer challenges are also addressed herein.
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spelling Finding the perfect match between nanoparticles and microfluidics to respond to cancer challengescancer theranosticDrug deliveryMicrofluidic devicesNanoparticlespoint-of-care devicesScience & TechnologyThe clinical translation of new cancer theranostic has been delayed by inherent cancerâ s heterogeneity. Additionally, this delay has been enhanced by the lack of an appropriate in vitro model, capable to produce accurate data. Nanoparticles and microfluidic devices have been used to obtain new and more efficient strategies to tackle cancer challenges. On one hand, nanoparticles-based therapeutics can be modified to target specific cells, and/or molecules, and/or modified with drugs, releasing them over time. On the other hand, microfluidic devices allow the exhibition of physiologically complex systems, incorporation of controlled flow, and control of the chemical environment. Herein, we review the use of nanoparticles and microfluidic devices to address different cancer challenges, such as detection of CTCs and biomarkers, point-of-care devices for early diagnosis and improvement of therapies. The future perspectives of cancer challenges are also addressed herein.F.R. Maia acknowledges Portuguese Foundation for Scienceand Technology (FCT) for her work contract under theTransitional Rule DL 57/2016 (CTTI-57/18-I3BS5). J. M.Oliveira thanks FCT for his distinction attributed under theFCT Investigator program (IF/01285/2015).ElsevierUniversidade do MinhoMaia, F. RaquelReis, R. L.Oliveira, Joaquim M.20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/66388engMaia F. R., Reis R. L., Oliveira J. M. Finding the Perfect Match between Nanoparticles and Microfluidics to respond to the Cancer Challenges, Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 24, pp. 102139, doi:10.1016/j.nano.2019.102139, 20191549-963410.1016/j.nano.2019.10213931843662https://doi.org/10.1016/ j.nano.2019.102139info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:39:07Zoai:repositorium.sdum.uminho.pt:1822/66388Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:35:40.894875Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Finding the perfect match between nanoparticles and microfluidics to respond to cancer challenges
title Finding the perfect match between nanoparticles and microfluidics to respond to cancer challenges
spellingShingle Finding the perfect match between nanoparticles and microfluidics to respond to cancer challenges
Maia, F. Raquel
cancer theranostic
Drug delivery
Microfluidic devices
Nanoparticles
point-of-care devices
Science & Technology
title_short Finding the perfect match between nanoparticles and microfluidics to respond to cancer challenges
title_full Finding the perfect match between nanoparticles and microfluidics to respond to cancer challenges
title_fullStr Finding the perfect match between nanoparticles and microfluidics to respond to cancer challenges
title_full_unstemmed Finding the perfect match between nanoparticles and microfluidics to respond to cancer challenges
title_sort Finding the perfect match between nanoparticles and microfluidics to respond to cancer challenges
author Maia, F. Raquel
author_facet Maia, F. Raquel
Reis, R. L.
Oliveira, Joaquim M.
author_role author
author2 Reis, R. L.
Oliveira, Joaquim M.
author2_role author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Maia, F. Raquel
Reis, R. L.
Oliveira, Joaquim M.
dc.subject.por.fl_str_mv cancer theranostic
Drug delivery
Microfluidic devices
Nanoparticles
point-of-care devices
Science & Technology
topic cancer theranostic
Drug delivery
Microfluidic devices
Nanoparticles
point-of-care devices
Science & Technology
description The clinical translation of new cancer theranostic has been delayed by inherent cancerâ s heterogeneity. Additionally, this delay has been enhanced by the lack of an appropriate in vitro model, capable to produce accurate data. Nanoparticles and microfluidic devices have been used to obtain new and more efficient strategies to tackle cancer challenges. On one hand, nanoparticles-based therapeutics can be modified to target specific cells, and/or molecules, and/or modified with drugs, releasing them over time. On the other hand, microfluidic devices allow the exhibition of physiologically complex systems, incorporation of controlled flow, and control of the chemical environment. Herein, we review the use of nanoparticles and microfluidic devices to address different cancer challenges, such as detection of CTCs and biomarkers, point-of-care devices for early diagnosis and improvement of therapies. The future perspectives of cancer challenges are also addressed herein.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/66388
url http://hdl.handle.net/1822/66388
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Maia F. R., Reis R. L., Oliveira J. M. Finding the Perfect Match between Nanoparticles and Microfluidics to respond to the Cancer Challenges, Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 24, pp. 102139, doi:10.1016/j.nano.2019.102139, 2019
1549-9634
10.1016/j.nano.2019.102139
31843662
https://doi.org/10.1016/ j.nano.2019.102139
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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