New findings in HCV genotype distribution in selected West European, Russian and Israeli regions

Bibliographic Details
Main Author: Kartashev, Vladimir
Publication Date: 2016
Other Authors: Döring, Matthias, Nieto, Leonardo, Coletta, Eleda, Kaiser, Rolf, Sierra, Saleta, HCV EuResist Study group, Guerrero, A., Stoiber, H., Paar, C., Vandamme, A. M., Nevens, F., Ranst, M. Van, Cuypers, L., Braun, P., Ehret, R., Obermeier, M., Schneeweiss, S., Scholten, S., Römer, K., Isernhagen, K., Qurashi, N., Heger, E., Knops, E., Neumann-Fraune, M., Timm, J., Walker, A., Lübke, N., Wedemeyer, H., Wiesch, J. Schulze zur, Lütgehetmann, M., Polywka, S., Däumer, M., Hoffmann, D., Protzer, U., Marascio, N., Foca, A., Liberto, M. C., Barreca, G. S., Galati, L., Torti, C., Pisani, V., Perno, C. F., Ceccherini-Silberstein, F., Cento, V., Ciotti, M., Zazzi, M., Rossetti, A., De Luca, A., Caudai, C., Mor, O., Devaux, C., Staub, T., Araujo, F., Gomes, P., Cabanas, J., Markin, N., Khomenko, I., Govorukhina, M., Lugovskaya, G., Dontsov, D., Mas, A., Martró, E., Saludes, V., Rodríguez-Frías, F., García, F., Casas, P., Iglesia, A. de la, Alados, J. C., Pena-López, M. J., Rodríguez, M. J., Galán, J. C., Suárez, A., Cardeñoso, L., Guerrero, M. D., Vegas-Dominguez, C., Blas-Espada, J., García, R., García-Bujalance, S., Benítez-Gutiérrez, L., Mendoza, C. de, Montiel, N., Santos, J., Viciana, I., Delgado, A., Martínez-Sanchez, P. A., Fernández-Alonso, M., Reina, G., Trigo, M., Echeverría, M. J., Aguilera, A., Navarro, D., Bernal, S., Lozano, M. C., Fernández-Cuenca, F., Orduña, A., Eiros, J. M., Ortíz de Lejarazu, R., Martínez-Sapiña, A. M., García-Díaz, A., Haque, T.
Format: Article
Language: eng
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: http://hdl.handle.net/10400.26/30652
Summary: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
id RCAP_04873815c6b916907be20e987937e8ad
oai_identifier_str oai:comum.rcaap.pt:10400.26/30652
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling New findings in HCV genotype distribution in selected West European, Russian and Israeli regionsGenotypeHCVHepatitis C virusMolecular epidemiologyTransmissionThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).BACKGROUND: HCV affects 185 million people worldwide and leads to death and morbidities. HCV has a high genetic diversity and is classified into seven genotypes and 67 subtypes. Novel anti-HCV drugs (Direct-Acting-Antivirals) eligibility, resistance and cure rates depend on HCV geno/subtype (GT). OBJECTIVES: Analysis of epidemiological information and viral GT from patients undergoing viral genotyping in 2011-2015. STUDY DESIGN: Anonymized information from 52 centers was analyzed retrospectively. RESULTS: 37,839 samples were included in the study. We show that the GT distribution is similar throughout Western European countries, with some local differences. Here GTs 1 and 2 prevalences are lower and of GT4 higher than in all previous reports. Israel has a unique GT pattern and in South Russia the GT proportions are more similar to Asia. GTs 5 and 6 were detected in very low proportions. Three cases of the recombinant genotype P were reported in Munich (Germany). In addition, we observed that GT proportion was dependant on patientś gender, age and transmission route: GTs 1b and 2 were significantly more common in female, older, nosocomially-infected patients, while GTs 1a, 3 and 4 were more frequent in male, younger patients infected by tattooing, drug consume, and/or sexual practices. In infections acquired by drug consume, GTs 1a (35.0%) and 3 (28.1%) prevailed. In infections related to sexual practices lower proportion of GT3 (14.0%) and higher of GT4 (20.2%) were detected. GT4 was mostly abundant in MSM (29.6%). HIV coinfection was significantly associated with higher proportions GTs 1a and 4 (42.5% and 19.3%, respectively). CONCLUSION: Genotype prevalence evolves and correlates to epidemiological factors. Continuous surveillance is necessary to better assess hepatitis C infection in Europe and to take appropriate actionsElsevierRepositório ComumKartashev, VladimirDöring, MatthiasNieto, LeonardoColetta, EledaKaiser, RolfSierra, SaletaHCV EuResist Study groupGuerrero, A.Stoiber, H.Paar, C.Vandamme, A. M.Nevens, F.Ranst, M. VanCuypers, L.Braun, P.Ehret, R.Obermeier, M.Schneeweiss, S.Scholten, S.Römer, K.Isernhagen, K.Qurashi, N.Heger, E.Knops, E.Neumann-Fraune, M.Timm, J.Walker, A.Lübke, N.Wedemeyer, H.Wiesch, J. Schulze zurLütgehetmann, M.Polywka, S.Däumer, M.Hoffmann, D.Protzer, U.Marascio, N.Foca, A.Liberto, M. C.Barreca, G. S.Galati, L.Torti, C.Pisani, V.Perno, C. F.Ceccherini-Silberstein, F.Cento, V.Ciotti, M.Zazzi, M.Rossetti, A.De Luca, A.Caudai, C.Mor, O.Devaux, C.Staub, T.Araujo, F.Gomes, P.Cabanas, J.Markin, N.Khomenko, I.Govorukhina, M.Lugovskaya, G.Dontsov, D.Mas, A.Martró, E.Saludes, V.Rodríguez-Frías, F.García, F.Casas, P.Iglesia, A. de laAlados, J. C.Pena-López, M. J.Rodríguez, M. J.Galán, J. C.Suárez, A.Cardeñoso, L.Guerrero, M. D.Vegas-Dominguez, C.Blas-Espada, J.García, R.García-Bujalance, S.Benítez-Gutiérrez, L.Mendoza, C. deMontiel, N.Santos, J.Viciana, I.Delgado, A.Martínez-Sanchez, P. A.Fernández-Alonso, M.Reina, G.Trigo, M.Echeverría, M. J.Aguilera, A.Navarro, D.Bernal, S.Lozano, M. C.Fernández-Cuenca, F.Orduña, A.Eiros, J. M.Ortíz de Lejarazu, R.Martínez-Sapiña, A. M.García-Díaz, A.Haque, T.2019-12-20T12:51:02Z2016-08-01T00:00:00Z2016-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/30652engJ Clin Virol. 2016 Aug;81:82-9. doi: 10.1016/j.jcv.2016.05.01010.1016/j.jcv.2016.05.01010.1016/j.jcv.2016.05.010info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:53:59Zoai:comum.rcaap.pt:10400.26/30652Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:44.335465Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv New findings in HCV genotype distribution in selected West European, Russian and Israeli regions
title New findings in HCV genotype distribution in selected West European, Russian and Israeli regions
spellingShingle New findings in HCV genotype distribution in selected West European, Russian and Israeli regions
Kartashev, Vladimir
Genotype
HCV
Hepatitis C virus
Molecular epidemiology
Transmission
title_short New findings in HCV genotype distribution in selected West European, Russian and Israeli regions
title_full New findings in HCV genotype distribution in selected West European, Russian and Israeli regions
title_fullStr New findings in HCV genotype distribution in selected West European, Russian and Israeli regions
title_full_unstemmed New findings in HCV genotype distribution in selected West European, Russian and Israeli regions
title_sort New findings in HCV genotype distribution in selected West European, Russian and Israeli regions
author Kartashev, Vladimir
author_facet Kartashev, Vladimir
Döring, Matthias
Nieto, Leonardo
Coletta, Eleda
Kaiser, Rolf
Sierra, Saleta
HCV EuResist Study group
Guerrero, A.
Stoiber, H.
Paar, C.
Vandamme, A. M.
Nevens, F.
Ranst, M. Van
Cuypers, L.
Braun, P.
Ehret, R.
Obermeier, M.
Schneeweiss, S.
Scholten, S.
Römer, K.
Isernhagen, K.
Qurashi, N.
Heger, E.
Knops, E.
Neumann-Fraune, M.
Timm, J.
Walker, A.
Lübke, N.
Wedemeyer, H.
Wiesch, J. Schulze zur
Lütgehetmann, M.
Polywka, S.
Däumer, M.
Hoffmann, D.
Protzer, U.
Marascio, N.
Foca, A.
Liberto, M. C.
Barreca, G. S.
Galati, L.
Torti, C.
Pisani, V.
Perno, C. F.
Ceccherini-Silberstein, F.
Cento, V.
Ciotti, M.
Zazzi, M.
Rossetti, A.
De Luca, A.
Caudai, C.
Mor, O.
Devaux, C.
Staub, T.
Araujo, F.
Gomes, P.
Cabanas, J.
Markin, N.
Khomenko, I.
Govorukhina, M.
Lugovskaya, G.
Dontsov, D.
Mas, A.
Martró, E.
Saludes, V.
Rodríguez-Frías, F.
García, F.
Casas, P.
Iglesia, A. de la
Alados, J. C.
Pena-López, M. J.
Rodríguez, M. J.
Galán, J. C.
Suárez, A.
Cardeñoso, L.
Guerrero, M. D.
Vegas-Dominguez, C.
Blas-Espada, J.
García, R.
García-Bujalance, S.
Benítez-Gutiérrez, L.
Mendoza, C. de
Montiel, N.
Santos, J.
Viciana, I.
Delgado, A.
Martínez-Sanchez, P. A.
Fernández-Alonso, M.
Reina, G.
Trigo, M.
Echeverría, M. J.
Aguilera, A.
Navarro, D.
Bernal, S.
Lozano, M. C.
Fernández-Cuenca, F.
Orduña, A.
Eiros, J. M.
Ortíz de Lejarazu, R.
Martínez-Sapiña, A. M.
García-Díaz, A.
Haque, T.
author_role author
author2 Döring, Matthias
Nieto, Leonardo
Coletta, Eleda
Kaiser, Rolf
Sierra, Saleta
HCV EuResist Study group
Guerrero, A.
Stoiber, H.
Paar, C.
Vandamme, A. M.
Nevens, F.
Ranst, M. Van
Cuypers, L.
Braun, P.
Ehret, R.
Obermeier, M.
Schneeweiss, S.
Scholten, S.
Römer, K.
Isernhagen, K.
Qurashi, N.
Heger, E.
Knops, E.
Neumann-Fraune, M.
Timm, J.
Walker, A.
Lübke, N.
Wedemeyer, H.
Wiesch, J. Schulze zur
Lütgehetmann, M.
Polywka, S.
Däumer, M.
Hoffmann, D.
Protzer, U.
Marascio, N.
Foca, A.
Liberto, M. C.
Barreca, G. S.
Galati, L.
Torti, C.
Pisani, V.
Perno, C. F.
Ceccherini-Silberstein, F.
Cento, V.
Ciotti, M.
Zazzi, M.
Rossetti, A.
De Luca, A.
Caudai, C.
Mor, O.
Devaux, C.
Staub, T.
Araujo, F.
Gomes, P.
Cabanas, J.
Markin, N.
Khomenko, I.
Govorukhina, M.
Lugovskaya, G.
Dontsov, D.
Mas, A.
Martró, E.
Saludes, V.
Rodríguez-Frías, F.
García, F.
Casas, P.
Iglesia, A. de la
Alados, J. C.
Pena-López, M. J.
Rodríguez, M. J.
Galán, J. C.
Suárez, A.
Cardeñoso, L.
Guerrero, M. D.
Vegas-Dominguez, C.
Blas-Espada, J.
García, R.
García-Bujalance, S.
Benítez-Gutiérrez, L.
Mendoza, C. de
Montiel, N.
Santos, J.
Viciana, I.
Delgado, A.
Martínez-Sanchez, P. A.
Fernández-Alonso, M.
Reina, G.
Trigo, M.
Echeverría, M. J.
Aguilera, A.
Navarro, D.
Bernal, S.
Lozano, M. C.
Fernández-Cuenca, F.
Orduña, A.
Eiros, J. M.
Ortíz de Lejarazu, R.
Martínez-Sapiña, A. M.
García-Díaz, A.
Haque, T.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Kartashev, Vladimir
Döring, Matthias
Nieto, Leonardo
Coletta, Eleda
Kaiser, Rolf
Sierra, Saleta
HCV EuResist Study group
Guerrero, A.
Stoiber, H.
Paar, C.
Vandamme, A. M.
Nevens, F.
Ranst, M. Van
Cuypers, L.
Braun, P.
Ehret, R.
Obermeier, M.
Schneeweiss, S.
Scholten, S.
Römer, K.
Isernhagen, K.
Qurashi, N.
Heger, E.
Knops, E.
Neumann-Fraune, M.
Timm, J.
Walker, A.
Lübke, N.
Wedemeyer, H.
Wiesch, J. Schulze zur
Lütgehetmann, M.
Polywka, S.
Däumer, M.
Hoffmann, D.
Protzer, U.
Marascio, N.
Foca, A.
Liberto, M. C.
Barreca, G. S.
Galati, L.
Torti, C.
Pisani, V.
Perno, C. F.
Ceccherini-Silberstein, F.
Cento, V.
Ciotti, M.
Zazzi, M.
Rossetti, A.
De Luca, A.
Caudai, C.
Mor, O.
Devaux, C.
Staub, T.
Araujo, F.
Gomes, P.
Cabanas, J.
Markin, N.
Khomenko, I.
Govorukhina, M.
Lugovskaya, G.
Dontsov, D.
Mas, A.
Martró, E.
Saludes, V.
Rodríguez-Frías, F.
García, F.
Casas, P.
Iglesia, A. de la
Alados, J. C.
Pena-López, M. J.
Rodríguez, M. J.
Galán, J. C.
Suárez, A.
Cardeñoso, L.
Guerrero, M. D.
Vegas-Dominguez, C.
Blas-Espada, J.
García, R.
García-Bujalance, S.
Benítez-Gutiérrez, L.
Mendoza, C. de
Montiel, N.
Santos, J.
Viciana, I.
Delgado, A.
Martínez-Sanchez, P. A.
Fernández-Alonso, M.
Reina, G.
Trigo, M.
Echeverría, M. J.
Aguilera, A.
Navarro, D.
Bernal, S.
Lozano, M. C.
Fernández-Cuenca, F.
Orduña, A.
Eiros, J. M.
Ortíz de Lejarazu, R.
Martínez-Sapiña, A. M.
García-Díaz, A.
Haque, T.
dc.subject.por.fl_str_mv Genotype
HCV
Hepatitis C virus
Molecular epidemiology
Transmission
topic Genotype
HCV
Hepatitis C virus
Molecular epidemiology
Transmission
description This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
publishDate 2016
dc.date.none.fl_str_mv 2016-08-01T00:00:00Z
2016-08-01T00:00:00Z
2019-12-20T12:51:02Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/30652
url http://hdl.handle.net/10400.26/30652
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Clin Virol. 2016 Aug;81:82-9. doi: 10.1016/j.jcv.2016.05.010
10.1016/j.jcv.2016.05.010
10.1016/j.jcv.2016.05.010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799129966884945920