Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | https://repositorio.unifesp.br/handle/11600/55442 http://dx.doi.org/10.1590/S1678-9946201759067 |
Resumo: | Despite recent advances in therapy for chronic hepatitis C (CHC), the disease caused by genotype 3 virus (GEN3) is still considered a treatment challenge in certain patient subgroups. The aim of this retrospective study was to evaluate the effectiveness and safety of the peginterferon (Peg-IFN) and ribavirin (RBV) combination treatment for GEN3/CHC patients, and to evaluate sustained virological response (SVR) indicators and early treatment interruption due to serious adverse events (SAE). This was a retrospective observational study of GEN3/CHC patients, co-infected or not by HIV and treated with Peg-IFN/RBV in nine Brazilian healthcare centers. The study sample included 184 GEN3/CHC patients |
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Grando, Aline VitaliAbrao Ferreira, Paulo Roberto [UNIFESP]Pessoa, Mario Guimaraesde Campos Mazo, Daniel FerrazBrandao-Mello, Carlos EduardoReuter, TaniaCandolo Martinelli, Ana de LourdesGonzalez, Mario PeribanezSeixas-Santos Nastri, Ana CatharinaCampos, Aleia FaustinaBanks Ferreira Lopes, Max IgorUrbaez Brito, Jose DavidMendes-Correa, Maria Cassia2020-07-17T14:03:30Z2020-07-17T14:03:30Z2017Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017.0036-4665https://repositorio.unifesp.br/handle/11600/55442http://dx.doi.org/10.1590/S1678-9946201759067S0036-46652017005000239.pdfS0036-4665201700500023910.1590/S1678-9946201759067WOS:000414712400001Despite recent advances in therapy for chronic hepatitis C (CHC), the disease caused by genotype 3 virus (GEN3) is still considered a treatment challenge in certain patient subgroups. The aim of this retrospective study was to evaluate the effectiveness and safety of the peginterferon (Peg-IFN) and ribavirin (RBV) combination treatment for GEN3/CHC patients, and to evaluate sustained virological response (SVR) indicators and early treatment interruption due to serious adverse events (SAE). This was a retrospective observational study of GEN3/CHC patients, co-infected or not by HIV and treated with Peg-IFN/RBV in nine Brazilian healthcare centers. The study sample included 184 GEN3/CHC patients70 (38%) were co-infected with HIV. The overall SVR rate was 57.1% (95% CI 50-64). Among co-infected and mono-infected patients, the SVR rate was 51.4% (36/70) and 60.5% (69/114), respectively (p=0.241). Thirty-four (18.5%) patients experienced SAE and interrupted treatment. SVR was negatively associated with the use of Peg-IFN alpha 2b (PR 0.7595% CI 0.58-0.99p=0.045) and to early treatment interruption due to SAE (PR 0.3695% CI 0.20-0.68p=0.001). Early treatment interruption due to SAE was associated with age (PR 1.0695% CI 1.02-1.10p<0.001) and occurrence of liver cirrhosis (PR 2.0695% CI 1.11-3.83p=0.022). In conclusion, Peg-IFN/RBV might represent an adequate treatment option, mainly in young patients without advanced liver disease or when the use of direct-action drugs is limited to specific patient groups.Univ Sul Santa Catarina, Fac Med, Dept Ciencias Biol & Saude & Ciencias Sociais Apl, Disciplina Doencas Infecciosas, Av Pedra Branca 25, BR-88137270 Palhoca, SC, BrazilUniv Fed Sao Paulo, Disciplina Infectol, Sao Paulo, SP, BrazilUniv Sao Paulo, Fac Med, Div Gastroenterol & Hepatol, Sao Paulo, SP, BrazilUniv Fed Estado Rio de Janeiro, Dept Clin Med, Disciplina Gastroenterol, Rio De Janeiro, RJ, BrazilUniv Fed Espirito Santo, Serv Infectol, Vitoria, ES, SpainUniv Sao Paulo, Fac Med Ribeirao Preto, Div Gastroenterol, Ribeirao Preto, SP, BrazilInst Infectol Emilio Ribas, Sao Paulo, SP, BrazilUniv Sao Paulo, Fac Med, Dept Doencas Infecciosas & Parasitarias, Sao Paulo, SP, BrazilSecretaria Estadual Saude, Unidade Mista Saude, Unimista 508 509, Brasilia, DF, BrazilUniv Sao Paulo, Inst Med Trop Sao Paulo, Lab Virol, LIM 52, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Disciplina Infectol, Sao Paulo, SP, BrazilWeb of Science-engInst Medicina Tropical Sao PauloRevista Do Instituto De Medicina Tropical De Sao PauloHepatitis CChronic hepatitis CCoinfection HCV-HIVInterferonsRibavirinHCV genotypesPeginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo59info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0036-46652017005000239.pdfapplication/pdf315299${dspace.ui.url}/bitstream/11600/55442/1/S0036-46652017005000239.pdfc73653e67fe4c2bdca7222ecfe74bb69MD51open accessTEXTS0036-46652017005000239.pdf.txtS0036-46652017005000239.pdf.txtExtracted texttext/plain34673${dspace.ui.url}/bitstream/11600/55442/11/S0036-46652017005000239.pdf.txt8966be1b9f0baa886a8aafa8f7d18bebMD511open accessTHUMBNAILS0036-46652017005000239.pdf.jpgS0036-46652017005000239.pdf.jpgIM Thumbnailimage/jpeg7370${dspace.ui.url}/bitstream/11600/55442/13/S0036-46652017005000239.pdf.jpg5335d6ce96fbe9918a0ca97fc17a2403MD513open access11600/554422023-06-05 19:29:11.185open accessoai:repositorio.unifesp.br:11600/55442Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:29:11Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.en.fl_str_mv |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| title |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| spellingShingle |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus Grando, Aline Vitali Hepatitis C Chronic hepatitis C Coinfection HCV-HIV Interferons Ribavirin HCV genotypes |
| title_short |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| title_full |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| title_fullStr |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| title_full_unstemmed |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| title_sort |
Peginterferon still has a place in the treatment of hepatitis C caused by genotype 3 virus |
| author |
Grando, Aline Vitali |
| author_facet |
Grando, Aline Vitali Abrao Ferreira, Paulo Roberto [UNIFESP] Pessoa, Mario Guimaraes de Campos Mazo, Daniel Ferraz Brandao-Mello, Carlos Eduardo Reuter, Tania Candolo Martinelli, Ana de Lourdes Gonzalez, Mario Peribanez Seixas-Santos Nastri, Ana Catharina Campos, Aleia Faustina Banks Ferreira Lopes, Max Igor Urbaez Brito, Jose David Mendes-Correa, Maria Cassia |
| author_role |
author |
| author2 |
Abrao Ferreira, Paulo Roberto [UNIFESP] Pessoa, Mario Guimaraes de Campos Mazo, Daniel Ferraz Brandao-Mello, Carlos Eduardo Reuter, Tania Candolo Martinelli, Ana de Lourdes Gonzalez, Mario Peribanez Seixas-Santos Nastri, Ana Catharina Campos, Aleia Faustina Banks Ferreira Lopes, Max Igor Urbaez Brito, Jose David Mendes-Correa, Maria Cassia |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Grando, Aline Vitali Abrao Ferreira, Paulo Roberto [UNIFESP] Pessoa, Mario Guimaraes de Campos Mazo, Daniel Ferraz Brandao-Mello, Carlos Eduardo Reuter, Tania Candolo Martinelli, Ana de Lourdes Gonzalez, Mario Peribanez Seixas-Santos Nastri, Ana Catharina Campos, Aleia Faustina Banks Ferreira Lopes, Max Igor Urbaez Brito, Jose David Mendes-Correa, Maria Cassia |
| dc.subject.eng.fl_str_mv |
Hepatitis C Chronic hepatitis C Coinfection HCV-HIV Interferons Ribavirin HCV genotypes |
| topic |
Hepatitis C Chronic hepatitis C Coinfection HCV-HIV Interferons Ribavirin HCV genotypes |
| description |
Despite recent advances in therapy for chronic hepatitis C (CHC), the disease caused by genotype 3 virus (GEN3) is still considered a treatment challenge in certain patient subgroups. The aim of this retrospective study was to evaluate the effectiveness and safety of the peginterferon (Peg-IFN) and ribavirin (RBV) combination treatment for GEN3/CHC patients, and to evaluate sustained virological response (SVR) indicators and early treatment interruption due to serious adverse events (SAE). This was a retrospective observational study of GEN3/CHC patients, co-infected or not by HIV and treated with Peg-IFN/RBV in nine Brazilian healthcare centers. The study sample included 184 GEN3/CHC patients |
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2017 |
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2017 |
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2020-07-17T14:03:30Z |
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2020-07-17T14:03:30Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017. |
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https://repositorio.unifesp.br/handle/11600/55442 http://dx.doi.org/10.1590/S1678-9946201759067 |
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0036-4665 |
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S0036-46652017005000239.pdf |
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10.1590/S1678-9946201759067 |
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WOS:000414712400001 |
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Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017. 0036-4665 S0036-46652017005000239.pdf S0036-46652017005000239 10.1590/S1678-9946201759067 WOS:000414712400001 |
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Sao Paulo |
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Inst Medicina Tropical Sao Paulo |
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Inst Medicina Tropical Sao Paulo |
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