How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia

Detalhes bibliográficos
Autor(a) principal: Delgadinho, Mariana
Data de Publicação: 2022
Outros Autores: Ginete, Catarina, Santos, Brígida, Fernandes, Carolina, Silva, Carina, Miranda, Armandina, Vasconcelos, Jocelyne Neto de, Brito, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/14922
Resumo: FCT/Aga Khan (project no. 330842553).
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spelling How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemiaHydroxyureaGut microbiomeSickle cell anemia16S rRNAChildrenAngolaFCT_Aga Khan (project no. 330842553)FCT_UIDB/05608/2020FCT_UIDP/05608/2020.FCT/Aga Khan (project no. 330842553).FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.Sickle cell anemia (SCA) is an inherited hematological disorder and a serious global health problem, especially in Sub-Saharan Africa. Although hydroxyurea (HU) is the leading treatment for patients with SCA, its effects on the gut microbiome have not yet been explored. In this context, the aim of this study was to investigate this association by characterizing the gut microbiome of an Angolan SCA pediatric population before and after 6 months of HU treatment. A total of 66 stool samples were obtained and sequenced for the 16S rRNA gene (V3-V4 regions). Significant associations were observed in alpha and beta-diversity, with higher values of species richness for the children naïve for HU. We also noticed that children after HU had higher proportions of several beneficial bacteria, mostly short-chain fatty acids (SCFAs) producing species, such as Blautia luti, Roseburia inulinivorans, Eubacterium halli, Faecalibacterium, Ruminococcus, Lactobacillus rogosae, among others. In addition, before HU there was a higher abundance of Clostridium_g24, which includes C. bolteae and C. clostridioforme, both considered pathogenic. This study provides the first evidence of the HU effect on the gut microbiome and unravels several microorganisms that could be considered candidate biomarkers for disease severity and HU efficacy.RCIPLDelgadinho, MarianaGinete, CatarinaSantos, BrígidaFernandes, CarolinaSilva, CarinaMiranda, ArmandinaVasconcelos, Jocelyne Neto deBrito, Miguel2022-08-22T14:54:09Z2022-082022-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14922engDelgadinho M, Ginete C, Santos B, Fernandes C, Silva C, Brito M, et al. How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia. Int J Mol Sci. 2022;23(16):9061.10.3390/ijms23169061info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:11:43Zoai:repositorio.ipl.pt:10400.21/14922Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:38.507698Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia
title How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia
spellingShingle How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia
Delgadinho, Mariana
Hydroxyurea
Gut microbiome
Sickle cell anemia
16S rRNA
Children
Angola
FCT_Aga Khan (project no. 330842553)
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020.
title_short How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia
title_full How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia
title_fullStr How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia
title_full_unstemmed How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia
title_sort How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia
author Delgadinho, Mariana
author_facet Delgadinho, Mariana
Ginete, Catarina
Santos, Brígida
Fernandes, Carolina
Silva, Carina
Miranda, Armandina
Vasconcelos, Jocelyne Neto de
Brito, Miguel
author_role author
author2 Ginete, Catarina
Santos, Brígida
Fernandes, Carolina
Silva, Carina
Miranda, Armandina
Vasconcelos, Jocelyne Neto de
Brito, Miguel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Delgadinho, Mariana
Ginete, Catarina
Santos, Brígida
Fernandes, Carolina
Silva, Carina
Miranda, Armandina
Vasconcelos, Jocelyne Neto de
Brito, Miguel
dc.subject.por.fl_str_mv Hydroxyurea
Gut microbiome
Sickle cell anemia
16S rRNA
Children
Angola
FCT_Aga Khan (project no. 330842553)
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020.
topic Hydroxyurea
Gut microbiome
Sickle cell anemia
16S rRNA
Children
Angola
FCT_Aga Khan (project no. 330842553)
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020.
description FCT/Aga Khan (project no. 330842553).
publishDate 2022
dc.date.none.fl_str_mv 2022-08-22T14:54:09Z
2022-08
2022-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/14922
url http://hdl.handle.net/10400.21/14922
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Delgadinho M, Ginete C, Santos B, Fernandes C, Silva C, Brito M, et al. How hydroxyurea alters the gut microbiome: a longitudinal study involving Angolan children with sickle cell anemia. Int J Mol Sci. 2022;23(16):9061.
10.3390/ijms23169061
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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