Microbial gut evaluation in an angolan paediatric population with sickle cell disease

Detalhes bibliográficos
Autor(a) principal: Delgadinho, Mariana
Data de Publicação: 2022
Outros Autores: Ginete, Catarina, Santos, Brígida, Mendes, Joana, Miranda, Armandina, Vasconcelos, Jocelyne, Brito, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/15033
Resumo: FCT/Aga Khan (project no. 330842553).
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spelling Microbial gut evaluation in an angolan paediatric population with sickle cell diseaseSickle cell diseaseFetal haemoglobinMicrobiome16S rRNAChildrenAngolaFCT_Aga Khan (project no. 330842553)FCT_UIDB/05608/2020FCT_UIDP/05608/2020FCT/Aga Khan (project no. 330842553).FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.Sickle cell disease (SCD) is one of the most common genetic conditions worldwide. It can contribute to up to 90% of under-5 mortality in sub-Saharan Africa. Clinical manifestations are very heterogeneous, and the intestinal microbiome appears to be crucial in the modulation of inflammation, cell adhesion, and induction of aged neutrophils, the main interveners of recurrent vaso-occlusive crisis. Enterocyte injury, increased permeability, altered microbial composition, and bacterial overgrowth have all been documented as microbial and pathophysiologic changes in the gut microbiome of SCD patients in recent studies. Our aim was to sequence the bacterial 16S rRNA gene in order to characterize the gut microbiome of Angolan children with SCA and healthy siblings as a control. A total of 72 stool samples were obtained from children between 3 and 14 years old. Our data showed that the two groups exhibit some notable differences in microbiota relative abundance at different classification levels. Children with SCA have a higher number of the phylum Actinobacteria. As for the genus level, Clostridium cluster XI bacteria was more prevalent in the SCA children, whereas the siblings had a higher abundance of Blautia, Aestuariispira, Campylobacter, Helicobacter, Polaribacter, and Anaerorhabdus. In this study, we have presented the first microbiota analysis in an Angolan paediatric population with SCD and provided a detailed view of the microbial differences between patients and healthy controls. There is still much to learn before fully relying on the therapeutic approaches for gut modulation, which is why more research in this field is crucial to making this a reality.WileyRCIPLDelgadinho, MarianaGinete, CatarinaSantos, BrígidaMendes, JoanaMiranda, ArmandinaVasconcelos, JocelyneBrito, Miguel2022-10-17T12:17:16Z2022-092022-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/15033engDelgadinho M, Ginete C, Santos B, Mendes J, Miranda A, Brito M, et al. Microbial gut evaluation in an angolan paediatric population with sickle cell disease. J Cell Mol Med. 2022;26(21):5360-8.10.1111/jcmm.17402info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:12:00Zoai:repositorio.ipl.pt:10400.21/15033Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:46.531273Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Microbial gut evaluation in an angolan paediatric population with sickle cell disease
title Microbial gut evaluation in an angolan paediatric population with sickle cell disease
spellingShingle Microbial gut evaluation in an angolan paediatric population with sickle cell disease
Delgadinho, Mariana
Sickle cell disease
Fetal haemoglobin
Microbiome
16S rRNA
Children
Angola
FCT_Aga Khan (project no. 330842553)
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
title_short Microbial gut evaluation in an angolan paediatric population with sickle cell disease
title_full Microbial gut evaluation in an angolan paediatric population with sickle cell disease
title_fullStr Microbial gut evaluation in an angolan paediatric population with sickle cell disease
title_full_unstemmed Microbial gut evaluation in an angolan paediatric population with sickle cell disease
title_sort Microbial gut evaluation in an angolan paediatric population with sickle cell disease
author Delgadinho, Mariana
author_facet Delgadinho, Mariana
Ginete, Catarina
Santos, Brígida
Mendes, Joana
Miranda, Armandina
Vasconcelos, Jocelyne
Brito, Miguel
author_role author
author2 Ginete, Catarina
Santos, Brígida
Mendes, Joana
Miranda, Armandina
Vasconcelos, Jocelyne
Brito, Miguel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Delgadinho, Mariana
Ginete, Catarina
Santos, Brígida
Mendes, Joana
Miranda, Armandina
Vasconcelos, Jocelyne
Brito, Miguel
dc.subject.por.fl_str_mv Sickle cell disease
Fetal haemoglobin
Microbiome
16S rRNA
Children
Angola
FCT_Aga Khan (project no. 330842553)
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
topic Sickle cell disease
Fetal haemoglobin
Microbiome
16S rRNA
Children
Angola
FCT_Aga Khan (project no. 330842553)
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
description FCT/Aga Khan (project no. 330842553).
publishDate 2022
dc.date.none.fl_str_mv 2022-10-17T12:17:16Z
2022-09
2022-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/15033
url http://hdl.handle.net/10400.21/15033
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Delgadinho M, Ginete C, Santos B, Mendes J, Miranda A, Brito M, et al. Microbial gut evaluation in an angolan paediatric population with sickle cell disease. J Cell Mol Med. 2022;26(21):5360-8.
10.1111/jcmm.17402
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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